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Controlled Trial of Sulpiride in Chronic Schizophrenic Patients

Published online by Cambridge University Press:  29 January 2018

J. Guy Edwards ,
John R. Alexander ,
M. S. Alexander ,
Alan Gordon  and
T. Zutchi
J. Guy Edwards
Affiliation:
Department of Psychiatry, Royal South Hants Hospital, Southampton SO9 4PE
John R. Alexander
Affiliation:
School of Mathematics, Statistics and Computing, Thames Polytechnic, London SE18 6PF
M. S. Alexander
Affiliation:
St James Hospital, Leeds LS9 7TF (Knowle Hospital, Fareham, Hants PO17 5NA)
Alan Gordon
Affiliation:
Knowle Hospital
T. Zutchi
Affiliation:
Holloway Sanatorium, Virginia Water, Surrey GU25 4BJ (Knowle Hospital)
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Summary

In a double-blind comparative trial of sulpiride (600–1,800 mg/day) and trifluoperazine (15–45 mg/day) in 38 chronic schizophrenic patients, ratings of therapeutic results and unwanted effects were made at two-weekly interviews during the six weeks treatment period. The results show that sulpiride has neuroleptic properties and a spectrum of therapeutic activity similar to that of trifluoperazine. There was an association between plasma sulpiride levels and therapeutic response after four weeks' treatment.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 137 , Issue 6 , December 1980 , pp. 522 - 529
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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