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Complement factor H and susceptibility to major depressive disorder in Han Chinese

  • Chen Zhang (a1), Deng-Feng Zhang (a2), Zhi-Guo Wu (a3), Dai-Hui Peng (a3), Jun Chen (a3), Jianliang Ni (a4), Wenxin Tang (a5), Lin Xu (a6), Yong-Gang Yao (a6) and Yi-Ru Fang (a7)...

Abstract

Background

Accumulating evidence suggests that altered immunity contributes to the development of major depressive disorder (MDD).

Aims

To examine whether complement factor H (CFH), a regulator of activation of the alternative pathway of the complement cascade, confers susceptibility to MDD.

Method

Expression analyses were tested in 53 unmedicated people with MDD and 55 healthy controls. A two-stage genetic association analysis was performed in 3323 Han Chinese with or without MDD. Potential associations between CFH single nucleotide polymorphisms and age at MDD onset were evaluated.

Results

CFH levels were significantly lower in the MDD group at both protein and mRNA levels (P = 0.009 and P = 0.014 respectively). A regulatory variant in the CFH gene, rs1061170, showed statistically significant genotypic and allelic differences between the MDD and control groups (genotypic P = 0.0005, allelic P = 0.0001). Kaplan–Meier survival analysis showed that age at onset of MDD was significantly associated with the C allele of rs1061170 (log rank statistic χ2 = 6.82, P = 0.009). The C-allele carriers had a younger age at onset of MDD (22.2 years, s.d. = 4.0) than those without the C allele (23.6 years, s.d. = 4.3).

Conclusions

CFH is likely to play an important role in the development of MDD. rs1061170 has an important effect on age at onset of MDD in Han Chinese and may therefore be related to early pathogenesis of MDD, although further study is needed.

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Copyright

Corresponding author

Yi-Ru Fang, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China. Email: yirufang@aliyun.com; Yong-Gang Yao, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiao Chang Dong Road, Kunming 650223, Yunnan, China. Email: yaoyg@mail.kiz.ac.cn

Footnotes

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These authors contributed equally to the work.

Declaration of interest

None.

Footnotes

References

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Complement factor H and susceptibility to major depressive disorder in Han Chinese

  • Chen Zhang (a1), Deng-Feng Zhang (a2), Zhi-Guo Wu (a3), Dai-Hui Peng (a3), Jun Chen (a3), Jianliang Ni (a4), Wenxin Tang (a5), Lin Xu (a6), Yong-Gang Yao (a6) and Yi-Ru Fang (a7)...
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