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Comments on the Northwick Park ‘Functional’ Psychosis Study

  • G. M. Goodwin (a1), D. A. W. Johnson (a2) and R. G. McCreadie (a3)

Abstract

“Functional psychosis is conventionally subdivided into schizophrenia and manic depressive psychosis. Response to treatment is assumed to be a validating criterion for these diagnoses. The efficacy of pimozide (a dopamine antagonist neuroleptic), lithium, and a combination of the two was compared with that of placebo in a 4-week trial in 120 functionally psychotic patients, each of whom was assessed for psychotic symptoms, manic symptoms, and depressive symptoms. The sample was subdivided into patients with predominantly elevated mood, predominantly depressed mood, and no consistent mood change. Pimozide reduced psychotic symptoms in all groups of patients. The only significant effect of lithium was to reduce elevated mood. Thus dopamine blockade seems relevant to the resolution of psychotic symptoms in all types of ‘functional’ psychosis, but the mode of action of lithium in psychotic patients concerns only mood. Application of standardised classifications of functional psychosis to these data did not change this conclusion.”

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References

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Brandon, S., Cowley, P., McDonald, C., et al (1984) Electroconvulsive therapy: results in depressive illness from the Leicestershire trial. British Medical Journal, 288, 2225.
Carlsson, A. (1978) Antipsychotic drugs, neurotransmitters and schizophrenia. American Journal of Psychiatry, 135, 164173.
Johnstone, E. C., Crow, T. J., Ruth, C. D., et al (1988) The Northwick Park “functional” psychosis study: diagnosis and treatment response. Lancet, ii, 119124.
Kendell, R. E. (1987) Diagnosis and classification of functional psychoses. British Medical Bulletin, 43, 499513.
Peroutka, S. J. & Snyder, S. H. (1980) Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic and histamine receptors to clinical potency. American Journal of Psychiatry, 137, 15121522.
Wood, A. J. & Goodwin, G. M. (1987) A review of the biochemical and neuropharmacological actions of lithium. Psychological Medicine, 137, 579600.

Comments on the Northwick Park ‘Functional’ Psychosis Study

  • G. M. Goodwin (a1), D. A. W. Johnson (a2) and R. G. McCreadie (a3)

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Comments on the Northwick Park ‘Functional’ Psychosis Study

  • G. M. Goodwin (a1), D. A. W. Johnson (a2) and R. G. McCreadie (a3)
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