Skip to main content Accessibility help
×
Home

A Clinical Trial of Phenelzine in Anxiety Depressive and Phobic Neuroses

  • C. Q. Mountjoy (a1), Martin Roth (a1), R. F. Garside (a1) and I. M. Leitch (a1)

Abstract

A double-blind clinical trial of phenelzine and diazepam against placebo and diazepam in neurotic patients over a four-week period showed phenelzine to be superior to placebo on three rating scales in some groups of patients who completed the trial. The findings suggest that phenelzine may exert a beneficial effect on some as yet undefined features of anxiety and depression which were not revealed by a multiple regression analysis of clinical symptomatology or premorbid personality.

Copyright

References

Hide All
British Pharmaceutical Codex (1968) London: The Pharmaceutical Press, pp 598–99.
Dally, P. J. & Rohde, P. (1961) Comparison of antidepressant drugs in depressive illness. Lancet, i, 1820.
Gelder, M. G. & Marks, I. M. (1966) Severe agoraphobia: a controlled prospective trial of behaviour therapy. British Journal of Psychiatry, 112, 309–19.
Glick, B. S. (1964) Double-blind study of tranylcypromine and phenelzine in depression. Diseases of the Nervous System, 25, 617–19.
Goodman, L. S. & Gilman, A. (1970) The Pharmacological Basis of Therapeutics, 4th edition, p 184. London: Collier-MacMillan Ltd
Greenblatt, M., Grosser, G. H. & Wechsler, H. (1964) Differential response of hospitalized depressed patients to somatic therapy. American Journal of Psychiatry, 120, 935–43.
Gurney, C., Roth, M., Garside, R. F., Kerr, T. A. & Schapira, K. (1972) Studies in the classification of affective disorders and the relationship between anxiety states and depressive illness. II. British Journal of Psychiatry, 121, 162–6.
Hamilton, M. (1959) The assessment of anxiety states by rating. British Journal of Medical Psychology, 32, 50–5.
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 5661.
Hare, E. H., Dominian, J. & Sharps, L. (1962) Phenelzine and dexamphetamine in depressive illness. British Medical Journal, i, 912.
Imlah, N. W., Fahy, P. T. P. & Harrington, J. A. (1964) A comparison of two antidepressant drugs. Psychopharmacologia, 6, 472–4.
Johnstone, E. C. & Marsh, W. (1973) Acetylator status and response to phenelzine in depressed patients. Lancet, i, 567–70.
Kay, D. W. K., Garside, R. F. & Fahy, T. J. (1973) A double-blind trial of phenelzine and amitriptyline in depressed out-patients: a possible differential effect of the drugs on symptoms. British Journal of Psychiatry, 123, 63–7.
Kelly, D., Guirguis, W., Frommer, E., Mitchell-Heggs, N. & Sargant, W. (1970) Treatment of phobic states with antidepressants: a retrospective study of 246 patients. British Journal of Psychiatry, 116, 387–98.
Kerr, T. A., Roth, M., Schapira, K. & Gurney, C. (1972) The assessment and prediction of outcome in affective disorders. British Journal of Psychiatry, 121, 167–74.
King, P. D. (1959) Phenelzine and ECT in the treatment of depressions. American Journal of Psychiatry, 116, 64–5.
Levy, L. & Lohrenz, J. (1960) the use of phenelzine sulphate (Nardil) in depression. Canadian Medical Association Journal, 82, 1031–2.
Lipsedge, M. S., Rees, W. L. & Pike, D. J. (1971) A double blind comparison of dothiepin and amitriptyline for the treatment of depression with anxiety. Psychopharmacologia (Berlin), 19, 153–62.
Martin, M. E. (1963) A comparative trial of imipramine and phenelzine in the treatment of depression. British Journal of Psychiatry, 109, 279–85.
Medical Research Council Report (1965) Clinical trial of the treatment of depressive illness. British Medical Journal, i, 881–6.
Mountjoy, C. Q. & Roth, M. (1975) A controlled trial of phenelzine in anxiety, depressive and phobic neuroses. Proceedings of the IXth Congress of the Collegium Internationale Neuropsychopharmacologicum. Paris 7–12 July 1974 (eds Boissier, J. R., Hippius, H. and Pichot, P.) (Excerpta Medica International Congress Series 359), pp 778–81.
Rao, C. R. (1952) Advanced Statistical Methods in Biometric Research, pp 112–15. New York: John Wiley
Raskin, A., Schulterbrandt, J. G., Reatig, N., Crook, T. H. & Odle, D. (1974) Depression subtypes and response to phelelzine, diazepam and a placebo. Archives of General Psychiatry, 30, 6675.
Ravaris, C. L., Nies, A., Robinson, D. S., Ives, J. O., Lamborn, K. R. & Korson, L. (1976) A multiple-dose, controlled study of phenelzine in depression-anxiety states. Archives of General Psychiatry, 33, 347–50.
Rees, L. & Davies, B. (1961) A controlled trial of phenelzine (Nardil) in the treatment of severe depressive illness. Journal of Mental Science, 107, 560–66.
Robinson, D. S., Nies, A., Ravaris, C. L. & Lamborn, K. R. (1973) The monoamine oxidase inhibitor, phenelzine, in the treatment of depressive anxiety states. Archives of General Psychiatry, 29, 407–13.
Sargant, W. & Dally, P. (1962) Treatment of anxiety states by antidepressant drugs. British Medical Journal, i, 79.
Sargant, W. & Slater, E. (1972) An Introduction to Physical Methods of Treatment in Psychiatry, 5th edition, p 45. Edinburgh and London: Churchill Livingstone
Snatch, R. P., Ahmed, S. N., Mehta, S. & Hamilton, M. (1971) Assessment of the severity of primary de-depressive illness. Wakefield self-assessment depression inventory. Psychological Medicine, 1, 143–9.
Solyom, L., Heseltine, G. F. D., McClure, D. J., Solyom, C., Ledwidge, B. & Steinberg, G. (1973) Behaviour therapy versus drug therapy in the treatment of phobic neurosis. Canadian Psychiatric Association Journal, 18, 2532.
Tyrer, P., Candy, J. & Kelly, D. (1973) Phenelzine in phobic anxiety: a controlled trial. Psychological Medicine, 3, 120–4.
Tyrer, P. (1976) Towards rational therapy with monoamine oxidase inhibitors. British Journal of Psychiatry, 128, 354–60.

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

A Clinical Trial of Phenelzine in Anxiety Depressive and Phobic Neuroses

  • C. Q. Mountjoy (a1), Martin Roth (a1), R. F. Garside (a1) and I. M. Leitch (a1)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *