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Cell density and cortical thickness in Heschl's gyrus in schizophrenia, major depression and bipolar disorder

  • David Cotter (a1), Daniel Mackay (a2), Sophia Frangou (a3), Lance Hudson (a2) and Sabine Landau (a4)...

Summary

There is evidence that the superior temporal gyrus and Heschl's gyrus within it are implicated in schizophrenia. We investigated neuronal and glial cell density and cortical thickness within Heschl's gyrus, using the optical disector to estimate cell density within cortical layers 3 and 5 in tissue derived postmortem from people with diagnoses of major depressive disorder, schizophrenia and bipolar disorder, compared with normal controls (n=15 per group). No significant difference in neuronal or glial cell density or in cortical thickness was observed between the groups; our findings therefore provide no support for the presence of cellular pathology within Heschl's gyrus in schizophrenia.

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Copyright

Corresponding author

Dr David R. Cotter, Beaumont Hospital, Dublin 9, Ireland. Tel: +353 1 809 3740; fax: +353 1 809 3741; e-mail: drcotter@rcsi.ie

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Declaration of interest

None. Funding detailed in Acknowledgements.

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References

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Barta, P. E., Pearlson, G. D., Brill, L. B., et al (1997) Planum temporale asymmetry reversal in schizophrenia: replication and relationship to gray matter abnormalities. American Journal of Psychiatry, 154, 661667.
Chana, G., Landau, S., Beasley, C., et al (2003) Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density. Biological Psychiatry, 15, 10861098.
Cotter, D., Mackay, D., Landau, S., et al (2001) educed glial cell density and neuronal size in the anterior cingulate cortex n major depressive disorder. Archives of General Psychiatry, 58, 545553.
Harrison, P., (1999) The neuropathology of schizophrenia: a critical review of the data and their interpretation. Brain, 122, 593624.
Pierri, J. N., Volk, C. L., Auh, S., et al (2001) Decreased somal size of deep layer 3 pyramidal neurons in the prefrontal cortex of subjects with schizophrenia. Archives of General Psychiatry, 58, 466473.
Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., et al (1999) Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biological Psychiatry, 45, 10851098.
Shergill, S. S., Brammer, M. J., Williams, S. C., et al (2000) Auditory hallucinations in schizophrenia using functional magnetic resonance imaging. Archives of General Psychiatry, 57, 10331038.
Sumich, A., Chitnis, X. A. & Fannon, D. G. (2002) Temporal lobe abnormalities in first-episode psychosis. American Journal of Psychiatry, 159, 12321236.
Torrey, E. F., Webster, M., Knable, M., et al (2000) The stanley foundation brain collection and neuropathology consortium. Schizophrenia Research, 44, 151155.
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Cell density and cortical thickness in Heschl's gyrus in schizophrenia, major depression and bipolar disorder

  • David Cotter (a1), Daniel Mackay (a2), Sophia Frangou (a3), Lance Hudson (a2) and Sabine Landau (a4)...

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Cell density and cortical thickness in Heschl's gyrus in schizophrenia, major depression and bipolar disorder

  • David Cotter (a1), Daniel Mackay (a2), Sophia Frangou (a3), Lance Hudson (a2) and Sabine Landau (a4)...
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