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Brain-Type Creatine Phosphokinase Serum Levels Before and After Ect

Published online by Cambridge University Press:  29 January 2018

M. G. T. Webb ,
M. P. O'Donnell ,
R. J. Draper ,
B. Horner  and
J. P. Phillips
M. G. T. Webb
Affiliation:
St. Patrick's Hospital, Dublin 8 and Trinity College, Dublin 2
M. P. O'Donnell
Affiliation:
St. Patrick's Hospital, Dublin 8 and Trinity College, Dublin 2
R. J. Draper
Affiliation:
St. Patrick's Hospital, Dublin 8 and Trinity College, Dublin 2
B. Horner
Affiliation:
St. Laurence's Hospital, Dublin 7
J. P. Phillips
Affiliation:
St. Laurence's Hospital, Dublin 7
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Summary

Brain-type creatine phosphokinase isoenzyme (CPK BB) was measured by radioimmunoassay in the serum of 31 depressed patients undergoing bilateral ECT. Samples were taken shortly before and at one hour, two hours, and six hours following ECT. ECT did not cause a significant alteration in serum CPK BB concentration during the six hours following the treatment. Similarly, there was no difference in mean pre-ECT concentration of serum CPK BB between patients receiving the first ECT of their current admission and those receiving subsequent treatments. These findings do not support suggestions that ECT causes alteration in permeability of the blood-brain barrier, nor that it causes detectable brain injury.

Type
Papers
Information
The British Journal of Psychiatry , Volume 144 , Issue 5 , May 1984 , pp. 525 - 528
Copyright
Copyright © 1984 The Royal College of Psychiatrists 

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