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A Biochemical Study of Short-Cycle Manic-Depressive Psychosis in Mental Defectives

Published online by Cambridge University Press:  29 January 2018

Graham J. Naylor ,
Andrew H. Reid ,
David A. T. Dick  and
Elizabeth G. Dick
Graham J. Naylor
Affiliation:
Department of Psychiatry, The University, Dundee
Andrew H. Reid
Affiliation:
Royal Dundee Liff Hospital, By Dundee
David A. T. Dick
Affiliation:
Department of Anatomy, The University, Dundee
Elizabeth G. Dick
Affiliation:
Department of Anatomy, The University, Dundee
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Summary

Four mentally defective patients who were suffering from short-cycle manic-depressive psychosis were each studied under metabolic ward conditions for about six months. Weekly estimations of erythrocyte Na-K ATPase activity, ouabain sensitive potassium influx, sodium concentration, whole blood cell ATP concentration and blood haematocrit were made. The findings in each patient differed, but the erythrocyte Na-K ATPase activity, sodium and ATP concentration appeared to show cyclic changes related to, though out of phase with, the clinical state.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 128 , Issue 2 , February 1976 , pp. 169 - 180
Copyright
Copyright © Royal College of Psychiatrists, 1976 

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