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Association of CACNA1C polymorphisms with serum BDNF levels in bipolar disorder

  • Erik Smedler (a1), Erik Pålsson (a2), Kenji Hashimoto (a3) and Mikael Landén (a4)

Abstract

Variation in the CACNA1C gene has been associated with bipolar disorder in several genome-wide association studies. This gene encodes the alpha 1C subunit of L-type voltage-gated calcium channels, which play an essential role in neurons. We analysed 39 biomarkers in either cerebrospinal fluid or serum in relation to six different CACNA1C variants in 282 patients with bipolar disorder and 90 controls. We report associations of CACNA1C risk alleles with serum levels of BDNF as well as tissue plasminogen activator, which converts pro-BDNF to mature BDNF. This sheds light on links between CACNA1C genetic variants and pathophysiological mechanisms in bipolar disorder.

Declaration of interest

None.

Copyright

Corresponding author

Correspondence: Erik Smedler, Blå Stråket 15, Sahlgrenska Universitetssjukhuset, 41345 Göteborg, Sweden. Email erik.smedler@gu.se

References

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Association of CACNA1C polymorphisms with serum BDNF levels in bipolar disorder

  • Erik Smedler (a1), Erik Pålsson (a2), Kenji Hashimoto (a3) and Mikael Landén (a4)
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