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Heritability of Schizophrenia

A Controlled Family History Investigation in Nigeria

Published online by Cambridge University Press:  02 January 2018

O. Gureje
Affiliation:
Department of Psychiatry, University College Hospital, PMB 5116, Ibadan, Nigeria
R. Bamidele
Affiliation:
Department of Psychiatry, University College Hospital, PMB 5116, Ibadan, Nigeria
Y. A. Aderibigbe
Affiliation:
Department of Psychiatry, University College Hospital, PMB 5116, Ibadan, Nigeria

Abstract

Thirty-six consecutively admitted patients with schizophrenia and 20 with mania were studied for the morbid risk of psychosis in their first-degree relatives. Using the family history method of ascertainment, the morbid risk for schizophrenia in the relatives of schizophrenic probands was 4.12% compared with 1.42% in the relatives of manic probands. While this difference was not statistically significant, that between the morbid risk for affective psychoses in the relatives of manic patients (7.81%) was significantly higher than for the relatives of schizophrenic patients (0%).

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Papers
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Copyright © 1994 The Royal College of Psychiatrists 

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