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Abnormal Metabolite in Alcoholic Subjects

Published online by Cambridge University Press:  29 January 2018

Stewart Wolf ,
Michael E. Felver ,
Mark D. Altschule ,
Nicholas T. Werthessen ,
Robert Gerner  and
Richard L. Veech
Stewart Wolf
Affiliation:
Totts Gap Medical Research Laboratories, Box 1262, Bangor, PA 18013, U.S.A.
Michael E. Felver
Affiliation:
Laboratory of Metabolism, N.I.A.A.A., 12501 Washington Avenue, Rockville, MD 20852, U.S.A.
Mark D. Altschule
Affiliation:
Francis A. Countway Library of Medicine, 10 Shattuck Street, Boston, MA 02115, U.S.A.
Nicholas T. Werthessen
Affiliation:
Office of Naval Research, Department of the Navy, 495 Summer Street, Boston, MA 00210, U.S.A.
Robert Gerner
Affiliation:
UCLA School of Medicine, Los Angeles, CA 90024, U.S.A.
Richard L. Veech
Affiliation:
Laboratory of Metabolism, N.I.A.A.A., 12501 Washington Avenue, Rockville, MD 20852, U.S.A.
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Summary

2,3-butanediol appears in the blood of some alcoholics following ethanol ingestion. Whether it be a genetic trait or a phenomenon of induction remains to be determined. It may be associated in some way with depression.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 142 , Issue 4 , April 1983 , pp. 388 - 390
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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References

Altschule, M. D., Werthessen, N. T. & Miller, S. A. (1977) High levels of endogenous 1,3-butanediol in the blood of a man after ethanol ingestion. Journal of Toxicology and Environmental Health, 3, 755–758.Google Scholar
Baker, R. N., Abantz, A. L. & Zack, J. F. Jr. (1969) Simultaneous determination of low alcohols acetone and acetaldehyde in blood by gas chromatography. Journal of Chromatographic Science, 7, 312–14.CrossRefGoogle Scholar
Dawson, J., Hullin, R. P. & Crockett, B. M. (1956a) Metabolic variations in manic-depressive psychosis. Journal of Mental Science, 102, 168–77.Google Scholar
Dawson, J., Hullin, R. P. & Pool, A. (1956b) Variations in the blood levels of acetoin and butane-2–3-diol in normal individuals and mental patients. Journal of Mental Science, 102, 168–71.Google Scholar
Dawson, J., Hullin, R. P. (1954) Metabolism of acetoin—the function and utilization of acetoin and butane 2,3 diol in decerebrated cat. Biochemical Journal, 57, 177–80.Google Scholar
Felver, M. E., Lakshmanan, M. R., Wolf, S. & Veech, R. L. (1980) The presence of 2,3-butanediol in the blood of chronic alcoholics admitted to an alcohol treatment center. Alcohol and Aldehyde Metabolizing Systems. IV. Thurman, R.G., (ed.) Advances in Experimental Medicine and Biology, 132, 229–35.Google Scholar
Mammer, O. A., Montgomery, J. A., Tjoa, S. S., Crawhall, J. C. & Feldkamp, C. S. (1978) Profiles in altered metabolism. I. The organic acids accumulating in acute non-diabetic ketoacidosis associated with alcoholism. Biomedical Mass Spectrometry, 5, 287–90.Google Scholar
Rutstein, D. D. & Veech, R. L. (1978) Genetics and addiction to alcohol. New England Journal of Medicine, 298, 1140–41.Google Scholar
Soling, H. D., Kohlhaw, G., Schnermann, J., Holzer, H. & Creutzfeldt, W. (1964) Zur Bedeutung des Acetoins fur die Pathogenese des Coma Hepaticum. Deutsch Medizinische Wochenschrift, 89, 457–63.Google Scholar
Stotz, E., Westerfeld, W. W. & Berg, R. L. (1944) The metabolism of acetaldehyde with acetoin formation. Journal Biological Chemistry, 154, 41–50.Google Scholar
Thölen, H., Bigler, F. & Staub, H. (1961) Zur Pathogenese des Urämiesyndroms. I Mitt: Der Gehalt von Acetoin und 2,3-Butylenglykol im Blut urämischer Patienten. Pathological Microbiology, 24, 262–92.Google Scholar
Thölen, H., Bigler, F., Heusler, A., Stouffacher, W., Staub, H. (1962a) Zur Pathogenese des Urämiesyndroms. Brentztraubensaure, Acetoin Leberkrank-berten. Experientia, 18, 454–5.Google Scholar
Thölen, H., Bigler, F. (1962b) Pathogenetische Beziehungen Zivischen uramischem und hepatischem Koma. Deutsch Medizinische Wochenschrift, 87, 1188–92.CrossRefGoogle Scholar
Thölen, H., Bigler, F., Heusler, A. & Staub, H. (1962c) Therapie des Leberkomas mit Coenzym A, α-Liponsaure, und Diphosphopyridinnukleotid. Deutsch Medizinische Wochenschrift, 87, 457–63.CrossRefGoogle Scholar
Veech, R. L., Felver, M. E., Lakshamnan, M. R., Huang, M. T. & Wolf, S. (1981) Control of a secondary pathway of ethanol metabolism by differences in redox state. In Current Topics in Cellular Regulation (ed. Bernard, L. Horecker). Volume 18, New York: Academic Press, 151–179.Google Scholar
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