Skip to main content Accessibility help
×
Home

Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size

  • Shu Jun Song (a1), Shaoyan Si (a1), Junli Liu (a1), Xingming Chen (a2), Ling Zhou (a3), Guiyue Jia (a4), Genlan Liu (a3), Yujing Niu (a3), Jie Wu (a5), Wenying Zhang (a3) and Jianzhong Zhang (a1)...

Abstract

Objective

To evaluate the prevalence of vitamin D deficiency in pregnant women and their newborns in Beijing, China and the influence of vitamin D deficiency on birth size.

Design

A cross-sectional study.

Setting

Data were collected from pregnant women who delivered during April to May 2010 at 306 Hospital of PLA in Beijing, China.

Subjects

Participants in the study were seventy healthy nulliparous pregnant women with singleton pregnancies who delivered healthy babies at full term and their newborns.

Results

Severe vitamin D deficiency (25-hydroxyvitamin D (25(OH)D) < 25 nmol/l) was detected in 54·5 % of mothers and 46·6 % of newborns. Neither mothers nor newborns had serum 25(OH)D concentrations that reached the normal level (>75 nmol/l). The concentration of 25(OH)D in mothers was positively correlated with that in cord blood (r = 0·89, P < 0·001). Newborns of mothers with severe vitamin D deficiency had lower birth length and birth weight. The head circumference and birth weight were lower in vitamin D-deficient newborns.

Conclusions

The study indicates that pregnant women and neonates residing in Beijing are at high risk of vitamin D deficiency. Neonatal 25(OH)D concentrations are dependently related to maternal 25(OH)D levels. Maternal and neonatal vitamin D status influences newborn size.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size
      Available formats
      ×

Copyright

Corresponding author

*Corresponding authors: Email zhangjz306@126.com, zh1365440@126.com

References

Hide All
1.Holick, MF (2011) Vitamin D: evolutionary, physiological and health perspectives. Curr Drug Targets 12, 418.
2.Mulligan, ML, Felton, SK, Riek, AEet al. (2010) Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol 202, 429, e1e9.
3.Dror, DK & Allen, LH (2010) Vitamin D inadequacy in pregnancy: biology, outcomes, and interventions. Nutr Rev 68, 465477.
4.Gale, CR, Robinson, SM, Harvey, NCet al. (2008) Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr 62, 6877.
5.Yu, CK, Sykes, L, Sethi, Met al. (2009) Vitamin D deficiency and supplementation during pregnancy. Clin Endocrinol (Oxf) 70, 685690.
6.Hollis, BW, Johnson, D, Hulsey, TCet al. (2011) Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 26, 23412357.
7.Mannion, CA, Gray-Donald, K, Koski, KGet al. (2006) Association of low intake of milk and vitamin D during pregnancy with decreased birth weight. CMAJ 174, 12731277.
8.Scholl, TO & Chen, X (2009) Vitamin D intake during pregnancy: association with maternal characteristics and infant birth weight. Early Hum Dev 85, 231234.
9.Leffelaar, ER, Vrijkotte, TG, van Eijsden, Met al. (2010) Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth: results of the multi-ethnic Amsterdam Born Children and their Development cohort. Br J Nutr 104, 108117.
10.Morley, R, Carlin, JB, Pasco, JAet al. (2006) Maternal 25-hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size. J Clin Endocrinol Metab 91, 906912.
11.Marya, RK, Rathee, S, Lata, Vet al. (1981) Effects of vitamin D supplementation in pregnancy. Gynecol Obstet Invest 12, 155161.
12.Marya, RK, Rathee, S, Dua, Vet al. (1988) Effect of vitamin D supplementation during pregnancy on foetal growth. Indian J Med Res 88, 488492.
13.Mallet, E, Gugi, B, Brunelle, Pet al. (1986) Vitamin D supplementation in pregnancy: a controlled trial of two methods. Obstet Gynecol 68, 300304.
14.Brooke, OG, Brown, IR, Bone, CDet al. (1980) Vitamin D supplements in pregnant Asian women: effects on calcium status and fetal growth. BMJ 280, 751754.
15.Sahu, M, Bhatia, V, Aggarwal, Aet al. (2009) Vitamin D deficiency in rural girls and pregnant women despite abundant sunshine in northern India. Clin Endocrinol (Oxf) 70, 680684.
16.Nicolaidou, P, Hatzistamatiou, Z, Papadopoulou, Aet al. (2006) Low vitamin D status in mother newborn pairs in Greece. Calcif Tissue Int 78, 337342.
17.Salek, M, Hashemipour, M, Aminorroaya, Aet al. (2008) Vitamin D deficiency among pregnant women and their newborns in Isfahan, Iran. Exp Clin Endocrinol Diabetes 116, 352356.
18.Holick, MF, Binkley, NC, Bischoff-Ferrari, HAet al. (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96, 19111930.
19.Wang, J, Yang, F, Mao, Met al. (2010) High prevalence of vitamin D and calcium deficiency among pregnant women and their newborns in Chengdu, China. World J Pediatr 6, 265267.
20.Bodnar, LM, Simhan, HN, Powers, RWet al. (2007) High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates. J Nutr 137, 447452.
21.Farrant, HJ, Krishnaveni, GV, Hill, JCet al. (2009) Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variation in newborn size. Eur J Clin Nutr 63, 646652.
22.van der Meer, IM, Karamali, NS, Boeke, AJet al. (2006) High prevalence of vitamin D deficiency in pregnant non-Western women in The Hague, Netherlands. Am J Clin Nutr 84, 350353.
23.Sachan, A, Gupta, R, Das, Vet al. (2005) High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India. Am J Clin Nutr 81, 10601064.
24.Hatun, S, Ozkan, B, Orbak, Zet al. (2005) Vitamin D deficiency in early infancy. J Nutr 135, 279282.
25.Kalra, P, Das, V, Agarwal, Aet al. (2012) Effect of vitamin D supplementation during pregnancy on neonatal mineral homeostasis and anthropometry of the newborn and infant. Br J Nutr (Epublication ahead of print version).
26.Weiler, H, Fitzpatrick-Wong, S, Veitch, Ret al. (2005) Vitamin D deficiency and whole-body and femur bone mass relative to weight in healthy newborns. CMAJ 172, 757761.
27.Morley, R, Carlin, JB, Pasco, JAet al. (2009) Maternal 25-hydroxyvitamin D concentration and offspring birth size: effect modification by infant VDR genotype. Eur J Clin Nutr 63, 802804.
28.Bodnar, LM, Catov, JM, Zmuda, JMet al. (2010) Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women. J Nutr 140, 9991006.
29.Mahon, P, Harvey, N, Crozier, Set al. (2010) Low maternal vitamin D status and fetal bone development: cohort study. J Bone Miner Res 25, 1419.
30.Kazemi, A, Sharifi, F, Jafari, Net al. (2009) High prevalence of vitamin D deficiency among pregnant women and their newborns in an Iranian population. J Womens Health 18, 835839.

Keywords

Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size

  • Shu Jun Song (a1), Shaoyan Si (a1), Junli Liu (a1), Xingming Chen (a2), Ling Zhou (a3), Guiyue Jia (a4), Genlan Liu (a3), Yujing Niu (a3), Jie Wu (a5), Wenying Zhang (a3) and Jianzhong Zhang (a1)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed