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Mediterranean dietary pattern is associated with lower incidence of premenopausal breast cancer in the Seguimiento Universidad de Navarra (SUN) Project

  • I Gardeazabal (a1) (a2), A Romanos-Nanclares (a1), MÁ Martínez-González (a1) (a3) (a4) (a5), A Castelló (a6) (a7) (a8), R Sánchez-Bayona (a1) (a2), B Pérez-Gómez (a6) (a7), C Razquin (a1) (a3) (a4), JM Aramendia-Beitia (a2), M Pollán (a6) (a7) and E Toledo (a1) (a3) (a4)...

Abstract

Objective:

Due to the growing interest in the role of dietary patterns (DPs) on chronic diseases, we assessed the association between a posteriori identified DPs in the Seguimiento Universidad de Navarra (SUN) Project – a prospective cohort study in a Mediterranean country – and breast cancer (BC) risk.

Design:

DPs were ascertained through a principal component analysis based on 31 predefined food groups. BC cases were initially identified through self-report or, if deceased, from death certificates or by notification by the next kin. Women reporting BC were asked to provide a copy of their medical report and diagnoses for confirmation purposes. We fitted Cox regression models to assess the association between adherence to the identified DPs and BC risk.

Setting:

Spanish university graduates.

Participants:

We included 10 713 young and middle-aged – mainly premenopausal – women.

Results:

After a median follow-up of 10·3 years, we identified 100 confirmed and 168 probable incident BC cases. We described two major DPs: ‘Western dietary pattern’ (WDP) and ‘Mediterranean dietary pattern’ (MDP). A higher adherence to a WDP was associated with an increased risk of overall BC (multivariable-adjusted HR for confirmed BC Q4 v. Q1 1·70; 95 % CI 0·93, 3·12; P for trend = 0·045). Contrarily, adherence to a MDP was inversely associated with premenopausal BC (multivariable-adjusted HR Q4 v. Q1 0·33; 95 % CI 0·12, 0·91). No significant associations were observed for postmenopausal BC.

Conclusions:

Whereas a higher adherence to the WDP may increase the risk of BC, a higher adherence to the MDP may decrease the risk of premenopausal BC.

Copyright

Corresponding author

*Corresponding author: Email etoledo@unav.es

References

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Mediterranean dietary pattern is associated with lower incidence of premenopausal breast cancer in the Seguimiento Universidad de Navarra (SUN) Project

  • I Gardeazabal (a1) (a2), A Romanos-Nanclares (a1), MÁ Martínez-González (a1) (a3) (a4) (a5), A Castelló (a6) (a7) (a8), R Sánchez-Bayona (a1) (a2), B Pérez-Gómez (a6) (a7), C Razquin (a1) (a3) (a4), JM Aramendia-Beitia (a2), M Pollán (a6) (a7) and E Toledo (a1) (a3) (a4)...

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