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Green tea and coffee intake and risk of cognitive decline in older adults: the National Institute for Longevity Sciences, Longitudinal Study of Aging

  • Yoshiro Shirai (a1), Kiyonori Kuriki (a1), Rei Otsuka (a2), Yuki Kato (a2) (a3), Yukiko Nishita (a4), Chikako Tange (a2), Makiko Tomida (a2), Tomoko Imai (a2) (a5), Fujiko Ando (a2) (a3) and Hiroshi Shimokata (a2) (a6)...



To examine the association between green tea and coffee intake and cognitive decline in older adults.


A prospective cohort study. The average intake of green tea and coffee in the previous year was assessed through a dietitian interview using a dietary questionnaire. A Mini-Mental State Examination (MMSE) was conducted up to six times biennially. Cognitive decline was screened using the MMSE; its incidence was defined as the first time a score of <27 points was obtained in a biennial test from the baseline. Hazard ratios for incidence of cognitive decline were estimated according to the intake of the two beverages using multivariable Cox proportional hazard regression, controlling for sociodemographic and lifestyle factors.


The National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA) in Japan.


Men (n 620) and women (n 685), aged 60–85 years, from the NILS-LSA.


During a mean of 5·3 (sd 2·9) years of follow-up, 432 incident cases of cognitive decline were observed. Compared with participants who consumed green tea <once/d, the multivariable hazard ratio (95 % CI) was 0·70 (0·45, 1·06), 0·71 (0·52, 0·97) and 0·72 (0·54, 0·98) among those who consumed green tea once/d, 2–3 times/d and ≥4 times/d, respectively (Ptrend < 0·05). No significant association was found between coffee intake and cognitive decline.


The intake of green tea, but not coffee, was shown to reduce the risk of cognitive decline in older adults.


Corresponding author

*Corresponding author: Email


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Present affiliation: Faculty of Human Life and Environment, Kinjo Gakuin University, Nagoya City, Aichi, Japan.



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1. World Health Organization (2012) Dementia: A Public Health Priority. Geneva: WHO.
2. Solfrizzi, V, Capurso, C, D’Introno, A et al. (2008) Lifestyle-related factors in predementia and dementia syndromes. Expert Rev Neurother 8, 133158.
3. Solfrizzi, V, Panza, F, Frisardi, V et al. (2011) Diet and Alzheimer’s disease risk factors or prevention: the current evidence. Expert Rev Neurother 11, 677708.
4. Unno, K, Takabayashi, F, Yoshida, H et al. (2007) Daily consumption of green tea catechin delays memory regression in aged mice. Biogerontology 8, 8995.
5. Unno, K, Takabayashi, F, Kishido, T et al. (2004) Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10). Exp Gerontol 39, 10271034.
6. Unno, K, Ishikawa, Y, Takabayashi, F et al. (2008) Daily ingestion of green tea catechins from adulthood suppressed brain dysfunction in aged mice. Biofactors 34, 263271.
7. Lee, JW, Lee, YK, Ban, JO et al. (2009) Green tea (–)-epigallocatechin-3-gallate inhibits β-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-κB pathways in mice. J Nutr 139, 19871993.
8. Arendash, GW, Schleif, W, Rezai-Zadeh, K et al. (2006) Caffeine protects Alzheimer’s mice against cognitive impairment and reduces brain β-amyloid production. Neuroscience 142, 941952.
9. Chu, YF, Chang, WH, Black, RM et al. (2012) Crude caffeine reduces memory impairment and amyloid β(1–42) levels in an Alzheimer’s mouse model. Food Chem 135, 20952102.
10. Arendash, GW, Mori, T, Cao, C et al. (2009) Caffeine reverses cognitive impairment and decreases brain amyloid-β levels in aged Alzheimer’s disease mice. J Alzheimers Dis 17, 661680.
11. Noguchi-Shinohara, M, Yuki, S, Dohmoto, C et al. (2014) Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline. PLoS One 9, e96013.
12. Tomata, Y, Sugiyama, K, Kaiho, Y et al. (2016) Green tea consumption and the risk of incident dementia in elderly Japanese: the Ohsaki Cohort 2006 study. Am J Geriatr Psychiatry 24, 881889.
13. Ng, TP, Feng, L, Niti, M et al. (2008) Tea consumption and cognitive impairment and decline in older Chinese adults. Am J Clin Nutr 88, 224231.
14. Arab, L, Biggs, ML, O’Meara, ES et al. (2011) Gender differences in tea, coffee, and cognitive decline in the elderly: the cardiovascular health study. J Alzheimers Dis 27, 553566.
15. van Gelder, BM, Buijsse, B, Tijhuis, M et al. (2007) Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE study. Eur J Clin Nutr 61, 226232.
16. Eskelinen, MH, Ngandu, T, Tuomilehto, J et al. (2009) Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. J Alzheimers Dis 16, 8591.
17. Laitala, VS, Kaprio, J, Koskenvuo, M et al. (2009) Coffee drinking in middle age is not associated with cognitive performance in old age. Am J Clin Nutr 90, 640646.
18. Tombaugh, TN & McIntyre, NJ (1992) The Mini-Mental State Examination: a comprehensive review. J Am Geriatr Soc 40, 922935.
19. Folstein, MF, Folstein, SE, McHugh, PR et al. (2001) Mini-Mental State Examination: User’s Guide. Odessa, FL: Psychological Assessment Resources, Inc.
20. Shimokata, H, Ando, F & Niino, N (2000) A new comprehensive study on aging – the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA). J Epidemiol 10, 1 Suppl., S1S9.
21. Mori, E, Mitani, Y & Yamadori, A (1985) Usefulness of a Japanese version of the Mini-Mental State Test in neurological patients. Jpn J Neuropsychol 1, 8290.
22. Folstein, MF, Folstein, SE & McHugh, PR (1975) ‘Mini-Mental State’. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189198.
23. Anstey, KJ, Lipnicki, DM & Low, LF (2008) Cholesterol as a risk factor for dementia and cognitive decline: a systematic review of prospective studies with meta-analysis. Am J Geriatr Psychiatry 16, 343354.
24. Mitchell, AJ (2009) A meta-analysis of the accuracy of the Mini-Mental State Examination in the detection of dementia and mild cognitive impairment. J Psychiatr Res 43, 411431.
25. Anstey, KJ, Burns, RA, Birrell, CL et al. (2010) Estimates of probable dementia prevalence from population-based surveys compared with dementia prevalence estimates based on meta-analyses. BMC Neurol 10, 62.
26. Devanand, DP, Pradhaban, G, Liu, X et al. (2007) Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease. Neurology 68, 828836.
27. Dik, MG, Jonker, C, Bouter, LM et al. (2000) APOE-ε4 is associated with memory decline in cognitively impaired elderly. Neurology 54, 14921497.
28. Johansson, MM, Marcusson, J & Wressle, E (2012) Cognition, daily living, and health-related quality of life in 85-year-olds in Sweden. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 19, 421432.
29. Krulewitch, H, London, MR, Skakel, VJ et al. (2000) Assessment of pain in cognitively impaired older adults: a comparison of pain assessment tools and their use by nonprofessional caregivers. J Am Geriatr Soc 48, 16071611.
30. Shimizu, H, Ohwaki, A, Kurisu, Y et al. (1999) Validity and reproducibility of a quantitative food frequency questionnaire for a cohort study in Japan. Jpn J Clin Oncol 29, 3844.
31. Imai, T, Sakai, S, Mori, K et al. (2000) Nutritional assessments of 3-day dietary records in National Institute for Longevity Sciences – Longitudinal Study of Aging (NILS-LSA). J Epidemiol 10, 1 Suppl., S70S76.
32. Iwai, N, Yoshiike, N, Saitoh, S et al. (2000) Leisure-time physical activity and related lifestyle characteristics among middle-aged Japanese. Japan Lifestyle Monitoring Study Group. J Epidemiol 10, 226233.
33. SAS Support (n.d.) Usage Note 22912: Testing for trends (linear, quadratic, cubic …) using PROC GLM. (accessed May 2019).
34. Lambert, JD & Elias, RJ (2010) The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention. Arch Biochem Biophys 501, 6572.
35. Biasibetti, R, Tramontina, AC, Costa, AP et al. (2013) Green tea (–)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia. Behav Brain Res 236, 186193.
36. Lee, YJ, Choi, DY, Yun, YP et al. (2013) Epigallocatechin-3-gallate prevents systemic inflammation-induced memory deficiency and amyloidogenesis via its anti-neuroinflammatory properties. J Nutr Biochem 24, 298310.
37. Rezai-Zadeh, K, Shytle, D, Sun, N et al. (2005) Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J Neurosci 25, 88078814.
38. Lin, CL, Chen, TF, Chiu, MJ et al. (2009) Epigallocatechin gallate (EGCG) suppresses β-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 β activation. Neurobiol Aging 30, 8192.
39. Ullmann, U, Haller, J, Decourt, JP et al. (2003) A single ascending dose study of epigallocatechin gallate in healthy volunteers. J Int Med Res 31, 88101.
40. Cao, C, Cirrito, JR, Lin, X et al. (2009) Caffeine suppresses amyloid-β levels in plasma and brain of Alzheimer’s disease transgenic mice. J Alzheimers Dis 17, 681697.
41. Dall’Igna, OP, Porciuncula, LO, Souza, DO et al. (2003) Neuroprotection by caffeine and adenosine A2A receptor blockade of β-amyloid neurotoxicity. Br J Pharmacol 138, 12071209.
42. Fredholm, BB, Battig, K, Holmen, J et al. (1999) Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 51, 83133.
43. Svilaas, A, Sakhi, AK, Andersen, LF et al. (2004) Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. J Nutr 134, 562567.
44. Natsume, M, Osakabe, N, Oyama, M et al. (2003) Structures of (–)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (–)-epicatechin: differences between human and rat. Free Radic Biol Med 34, 840849.
45. Kimura, D, Nakatani, K, Takeda, T et al. (2015) Analysis of causal relationships by structural equation modeling to determine the factors influencing cognitive function in elderly people in Japan. PLoS One 10, e0117554.


Green tea and coffee intake and risk of cognitive decline in older adults: the National Institute for Longevity Sciences, Longitudinal Study of Aging

  • Yoshiro Shirai (a1), Kiyonori Kuriki (a1), Rei Otsuka (a2), Yuki Kato (a2) (a3), Yukiko Nishita (a4), Chikako Tange (a2), Makiko Tomida (a2), Tomoko Imai (a2) (a5), Fujiko Ando (a2) (a3) and Hiroshi Shimokata (a2) (a6)...


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