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Nutrition in paediatric human immunodeficiency virus infection

Published online by Cambridge University Press:  28 February 2007

Tracie L. Miller
Tracie L. Miller*
Affiliation:
University of Rochester Medical Center, Children's Hospital at Strong, 601 Elmwood Avenue, Box 667, Rochester, NY 14642, USA
*
*Corresponding author: Dr Tracie L. Miller, fax +1 716 461 5913, email tracie_miller@urmc.rochester.edu
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Abstract

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The nutritional condition of children with human immunodeficiency virus (HIV) infection continues to be a problem both in developed and developing countries. HIV-infected children grow below normal standards in both height and weight when compared with HIV-exposed non-infected children. These patterns persist over time. It is possible that acute infectious episodes and increased HIV viral burden contribute to decrements in all growth variables. Potential aetiologies for abnormal growth include inadequate dietary intake, gastrointestinal malabsorption, increased energy utilization and psycho-social problems. It is likely that all these factors contribute to the growth problems of these children to some extent. With the development of protease inhibitor anti-retroviral therapy and highly-active anti-retroviral treatment regimens, children with HIV infection in developed countries are living longer with a chronic illness. New nutritional problems have arisen with the development of the fat redistribution syndrome or lipodystrophy. Emerging problems are now being recognized, with the development of insulin resistance and truncal obesity which may potentially lead to premature cardiovascular disease.

Keywords

Human immunodeficiency virusAcquired immune deficiency syndromeNutritional statusMalnutritionChildren
Type
Clinical Nutrition and Metabolism Group Symposium on ‘Clinical nutrition in childhood’
Information
Proceedings of the Nutrition Society , Volume 59 , Issue 1 , February 2000 , pp. 155 - 162
Copyright
Copyright © The Nutrition Society 2000

References

Arpadi, SM, Horlick, MN, Wang, J, Cuff, P, Bamji, M & Kotler, DP (1998) Body composition in prepubertal children with human immunodeficiency virus type 1 infection. Archives of Pediatrics and Adolescent Medicine 152, 688–693.CrossRefGoogle ScholarPubMed
Berhane, RAE, Aceng, E, Marum, L, Bagenda, D, Bosch, R, Ndugwa, C & Olness, K (1996) Physical growth and mortality risk in children with perinatally acquired HIV. Pediatric AIDS and HIV Infection 7, 281.Google Scholar
Butler, KM, Husson, R, Lewis, L, Mueller, B, Gress, J, Jacobsen, F, Higham, C, Montrella, K, Jarosinski, P, Balis, FM, Venson, D & Henry, N (1993) Pancreatitis in human immunodeficiency virus-infected children receiving dideoxyinosine. Pediatrics 91, 747–751.Google Scholar
Carr, A, Samaras, K, Burton, S, Law, M, Freund, J, Chisholm, DJ & Cooper, DA (1998a) A syndrome of peripheral lipodystrophy, hyperlipidemia, and insulin resistance in patients receiving HIV protease inhibitors. AIDS 12, F51–F58.Google Scholar
Carr, A, Samaras, K, Chisholm, DJ & Cooper, DA (1998b) Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance. Lancet 351, 1881–1883.Google Scholar
Carr, A, Samaras, K, Thorisdottir, A, Kaufman, GR, Chisholm, DJ & Cooper, DA (1999) Diagnosis, prediction, and natural course of HIV-1 protease inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: a cohort study. Lancet 353, 2093–2099.Google Scholar
Center for Disease Control (1993) 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Mortality and Morbidity Weekly Review 41, 1–19.Google Scholar
Centers for Disease Control, Task, Force on Kaposi's Sarcoma and Opportunistic, Infections (1982) Epidemiologic aspects of the current outbreak of Kaposi's Sarcoma and opportunistic infection. New England Journal of Medicine 306, 248–252.Google Scholar
Chandra, RK & Newbuerne, PM (1977) Nutrition, Immunity and Infection: Mechanisms of Interactions. New York: Plenum Press.CrossRefGoogle Scholar
Chlebowski, RT, Grosvenor, MB, Berhard, NH, Morales, LS & Bulcavage, LM (1989) Nutritional status, gastrointestinal dysfunction, and survival in patients with AIDS. American Journal of Gastroenterology 84, 1288–1293.Google Scholar
Clarick, RH, Hanekom, W, Yogev, R & Chadwick, EG (1997) Megestrol acetate treatment of growth failure in children with human immunodeficiency virus. Pediatrics 99, 354–357.Google Scholar
Connor, EM, Sperling, RS, Gelber, R, Kiselev, P, Scott, G, O'Sullivan, MJ, VanDyke, R, Bey, M, Shearer, W & Jacobson, RL (1994) Reduction of maternal-infant transmission of human immunodeficiency virus type-1 with zidovudine treatment. New England Journal of Medicine 31, 1173–1180.Google Scholar
Dube, MP, Johnson, DL, Currier, JS & Leedom, JM (1997) Protease inhibitor-associated hyperglycaemia. Lancet 350, 713–714.Google Scholar
Falloon, J, Eddy, J, Wiener, L & Pizzo, PA (1989) Human immunodeficiency virus infection in children. Journal of Pediatrics 114, 1–30.Google Scholar
Flores, EA, Bistrian, BR, Pomposelli, JJ, Dinarella, CA, Blackburn, GL & Istfan, NW (1989) Infusion of tumor necrosis factor/ cachectin promotes muscle catabolism in the rat: a synergistic effect with interleukin 1. Journal of Clinical Investigation 83, 1614–1622.Google Scholar
Gallo, RC, Salahuddin, SZ, Popovic, M, Shearer, GM, Kaplan, M, Haynes, BF, Palker, TJ, Redfield, R, Oleske, J & Safai, B (1984) Frequency, detection, and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science 124, 500–503.Google Scholar
Greene, JB (1988) Clinical approach to weight loss in the patient with HIV infection. Gastroenterology Clinics of North America 17, 573–586.Google Scholar
Henderson, RA, Miotti, PG, Saavedra, JM, Dallabetta, G, Chiphangwi, J, Liomba, G, Taha, TE & Yolken, RH (1996) Longitudinal growth during the first two years of life in children born to HIV-infected mothers in Malawi, Africa. Pediatric AIDS and HIV Infection 7, 91–97.Google Scholar
Henderson, RA, Saavedra, J, Perman, JA, Hutton, N, Livingston, RA & Yolken, RH (1994) Effect of enteral tube feeding on growth of children with symptomatic human immunodeficiency virus infection. Journal of Pediatric Gastroenterology and Nutrition 18, 429–434.Google Scholar
Henderson, RA, Talusan, K, Hutton, N, Yolken, RH & Caballero, B (1997) Serum and plasma markers of nutritional status in children infected with the human immunodeficiency virus. Journal of the American Dietetic Association 97, 1377–1381.CrossRefGoogle ScholarPubMed
Henderson, RA, Talusan, K, Hutton, N, Yolken, RH & Caballero, B (1998) Resting energy expenditure and body composition in children with HIV infection. Journal of Acquired Immune Deficiency Syndromes 19, 150–157.Google Scholar
Henry, K, Rahtgaber, S, Sullivan, C & McCarbe, K (1992) Diabetes mellitus induced by megestrol acetate in a patient with AIDS and cachexia. Annals of Internal Medicine 116, 53–54.Google Scholar
Hommes, MJ, Romijn, JA, Endert, E & Sauerwein, HP (1991) Resting energy expenditure and substrate oxidation in human immunodeficiency virus (HIV)-infected asymptomatic men: HIV affects host metabolism in the early asymptomatic stage. American Journal of Clinical Nutrition 54, 311–315.Google Scholar
Hughes, WT, Price, RA & Sisko, F (1974) Protein-calorie malnutrition: a host determinant for Pneumocystis carinii infection. American Journal of Diseases of Children 128, 44–52.CrossRefGoogle ScholarPubMed
Katz, MH, Mastrucci, MT, Leggott, PJ, Westenhouse, J, Greenspan, JS & Scott, GB (1993) Prognostic significance of oral lesions in children with perinatally acquired human immunodeficiency virus infection. American Journal of Diseases of Children 147, 45–48.Google ScholarPubMed
Kotler, DP, Gaetz, HP, Lange, M, Klein, EB & Holt, PR (1984) Enteropathy associated with the acquired immunodeficiency syndrome. Annals of Internal Medicine 104, 421–428.CrossRefGoogle Scholar
Kotler, DP, Tierney, AR, Wang, J & Pierson, RN (1989) Magnitude of body-cell-mass depletion and the timing of death from wasting in AIDS. American Journal of Clinical Nutrition 50, 444–447.Google Scholar
Lake-Bakaar, Quadros E, Beidas, S, Elsakr, M, Tom, W, Wilson, DE, Dincsay, HP, Cohen, P & Straus, EW (1988) Gastric secretory failure in patients with the acquired immunodeficiency syndrome (AIDS). Annals of Internal Medicine 109, 502–504.CrossRefGoogle ScholarPubMed
Mgone, CS, Mhalu, FS, Shao, JF, Britton, S, Sandstrom, A, Bredberg-Raden, U & Biberfeld, G (1991) Prevalence of HIV-1 infection and symptomatology of AIDS in severely malnourished children in Dar Es Salaam, Tanzania. Journal of Acquired Immune Deficiency Syndromes 4, 910–913.Google Scholar
Miller, TL, Awnetwant, E, Evans, S, Morris, VM & Vazquez, IM (1995) Gastrostomy tube supplementation for HIV-Infected children. Pediatrics 96, 696–702.Google Scholar
Miller, TL, Evans, S, Orav, EJ, McIntosh, K & Winter, HS (1993) Growth and body composition in children with human immunodeficiency virus-1 infection. American Journal of Clinical Nutrition 57, 588–592.Google Scholar
Miller, TL, Evans, S, Vasquez, I & Orav, EJ (1997a) Dietary intake is an important predictor of nutritional status in HIV-infected children. Pediatric Research 41, 85A.Google Scholar
Miller, TL, McQuinn, L & Orav, EJ (1997b) Endoscopy of the upper gastrointestinal tract as a diagnostic tool for children with human immunodeficiency infection. Journal of Pediatrics 130, 766–773.Google Scholar
Miller, TL, Orav, EJ, Colan, S & Lipshultz, SE (1997c) Nutritional status and cardiac mass and function in children infected with the human immunodeficiency virus. American Journal of Clinical Nutrition 66, 660–664.Google Scholar
Miller, TL, Orav, EJ, Martin, SR, Cooper, ER, McIntosh, K & Winter, HS (1991) Malnutrition and carbohydrate malabsorption in children with vertically-transmitted human immunodeficiency virus-1 infection. Gastroenterology 100, 1296–1302.Google Scholar
Miller, TL, Winter, H, Luginbuhl, LM, Orav, EJ & McIntosh, KS (1992) Pancreatitis in pediatric human immunodeficiency virus infection. Journal of Pediatrics 120, 223–227.Google Scholar
Moye, J, Rich, KC, Kalish, LA, Sheon, AR, Diaz, C, Cooper, ER, Pitt, J & Handelsman, E for the Women and Infants Transmission Study Group (1996) Natural history of somatic growth in infants born to women infected by human immunodeficiency virus. Journal of Pediatrics 128, 58–69.Google Scholar
National, Research Council (1989) Recommended Dietary Allowances, revised ed. Washington, DC: National Academy Press.Google Scholar
Oster, MH, Enders, SR, Samuels, SJ, Cone, LA, Hooton, TM, Browder, DP & Flynn, NM (1994) Megestrol acetate in patients with AIDS and cachexia. Annals of Internal Medicine 121, 400–408.Google Scholar
Pitt, J, Goldfarb, J, Schluchter, M, Kovacs, A, Cooper, E, Hodes, D, MacIntosh, K, Peavy, H & Shearer, W (1998) HIV vertical transmission rate determinations are subject to differing definitions and therefore different rates. The Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Group. Journal of Clinic Epidemiology 51, 159–164.Google Scholar
Pizzo, PA & Wilfert, CM (editors) (1989) In Pediatric AIDS: The Challenge of HIV Infection in Infants, Children and Adolescents,3rd ed. Baltimore, MD: Williams and Wilkins Publishers.Google Scholar
Saavedra, JM, Henderson, R, Perman, JA, Hutton, N, Livingston, RA & Yolken, RH (1995) Longitudinal assessment of growth in children born to mothers with human immunodeficiency virus infection. Archives of Pediatrics and Adolescent Medicine 149, 497–502.Google Scholar
Scrimshaw, NS, Taylor, CE & Gordon, JE (1968) Interactions of Nutrition and Infection. WHO Monograph Series no. 57.Geneva: WHO.Google Scholar
Striker, R, Conlin, D, Marx, M & Wiviott, L (1998) Localized adipose tissue hypertrophy in patients receiving human immunodeficiency virus protease inhibitors. Clinical Infectious Disease 27, 218–220.CrossRefGoogle ScholarPubMed
Suttmann, U, Ockenga, L, Hoogestraat, L, Selberg, O, Schedel, I, Deicher, H & Muller, MJ (1993) Resting energy expenditure and weight loss in human immunodeficiency virus-infected patients. Metabolism 42, 1173–1179.Google Scholar
The European Collaborative Study (1995) Weight, height, and human immunodeficiency virus infection in young children of infected mothers. Pediatric Infectious Diseases Journal 14, 685–690.Google Scholar
The Italian Pediatric Intestinal/HIV Study Group (1993) Intestinal malabsorption of HIV-infected children: relationship to diarrhea, failure to thrive, enteric micro-organisms and immune impairment. AIDS 7, 1435–1440.Google Scholar
Ullrich, R, Zeitz, M, Heise, W, L'age, M, Hoffken, G & Riecken, EO (1989) Small intestinal structure and function in patients infected with human immunodeficiency virus (HIV): Evidence for HIV-induced enteropathy. Annals of Internal Medicine 111, 15–21.CrossRefGoogle ScholarPubMed
von, Roenn JH, Murphy, RL, Weber, KM, Williams, LM & Weitzman, SA (1994) Megestrol acetate in patients with AIDS-related cachexia. Annals of Internal Medicine 121, 393–399.Google Scholar
Yolken, RH, Hart, W, Oung, I, Schiff, C, Greenson, J & Perman, JA (1991) Gastrointestinal-dysfunction and diasaccharide intolerance in children infected with human immunodeficiency virus. Journal of Pediatrics 118, 359–363.Google Scholar
Zuin, G, CD, , Fontana, M (1994) Energy and nutrient intakes in HIV-infected children. Pediatric AIDS and HIV Infection 5, 159–161.Google Scholar