Skip to main content Accessibility help

n-3 Polyunsaturated fatty acids and immune function

  • Dayong Wu (a1) and Simin Nikbin Meydani (a1)
    • Send article to Kindle

      To send this article to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      n-3 Polyunsaturated fatty acids and immune function
      Available formats

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      n-3 Polyunsaturated fatty acids and immune function
      Available formats

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      n-3 Polyunsaturated fatty acids and immune function
      Available formats


  • An abstract is not available for this content so a preview has been provided below. To view the full text please use the links above to select your preferred format.


Corresponding author

*Corresponding author: Dr Simin Nikbin Meydani, fax +1 617 556 3224, email


Hide All
Aki, H, Morinaga, SI, Yamazaki, K, Suzuki, H & Nakamura, N (1992) Reduction of delayed-type hypersensitivity by the injection of n-3 polyunsaturated fatty acid in mice. Transplantation 54, 511514.
Berger, A, German, JB, Chiang, BL, Ansari, AA, Keen, CL, Fletcher, MP & Gershwin, ME (1993) Influence of feeding unsaturated fats on growth and immune status of mice. Journal of Nutrition 123, 225233.
Brunda, MJ, Heberman, RB & Holden, HT (1980) Inhibition of natural killer cell activity by prostaglandins. Journal of Immunology 124, 26822687.
Calder, PC (1996) Immunomodulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids. Proceedings of the Nutrition Society 55, 737774.
Calder, PC & Newsholme, EA (1992) Polyunsaturated fatty acids suppress human peripheral blood lymphocyte proliferation and interleukin-2 production. Clinical Science 37, 695700.
Caughey, GE, Mantzioris, E, Gibson, RA, Cleland, LG & James, MJ (1996) The effect on human tumor necrosis factor α and interleukin 1β production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. American Journal of Clinical Nutrition 63, 116122.
Chang, HR, Dulloo, AG, Vladoianu, IR, Piguet, PF, Arsenijevic, D, Girardier, L & Pechere, JC (1992) Fish oil decreases natural resistance of mice infection with Salmonella typhimurium. Metabolism 41. 12.
Christophe, B & Pascaud, M (1990) Effects of moderate dietary supplementations with n-3 fatty acids on macrophage eicosanoid synthesis in the rat. Biochimica et Biophysica Acta 1047, 1928.
Clandinin, MT, Cheema, S, Field, CJ, Garg, ML, Venkatraman, J & Clandinin, TR (1991) Dietary fat: exogenous determination of membrane structure and cell function. FASEB Journal 5, 27612769.
Davits, FA & Nugteren, A (1988) The urinary excretion of prostaglandin E and their corresponding tetranor metabolites by rats fed a diet rich in eicosapentaenoate. Biochimica et Biophysica Acta 958, 289299.
Dyerberg, J & Bang, HO (1979) Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet ii, 433435.
Dyerberg, J, Bang, HO, Stoffersen, E, Moncada, S & Vane, J (1978) Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis. Lancet ii, 117119.
Endres, S, Ghorbani, R, Kelley, VE, Georgilis, K, Lonneman, G, Van der Meer, WM, Cannon, JG, Rogers, TS, Klempner, MS, Webber, PC, Schaefer, EJ, Wolf, SM & Dinarello, DA (1989) The effect of dietary supplementation with (n-3) polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. New England Journal of Medicine 320, 265271.
Endres, S, Meydani, SN, Ghorbani, R, Schindler, R & Dinarello, CA (1993) Dietary n-3 fatty acids suppress interleukin-2 production and mononuclear cell proliferation. Journal of Leukocyte Biology 54, 599603.
Engstrom, K, Luostarinen, R & Saldeen, T (1996) Whole blood production of thromboxane, prostacyclin and leukotriene B4 after dietary fish oil supplementation in man: effect of vitamin E. Prostaglandins, Leukotrienes and Essential Fatty Acids 54, 419425.
Farwer, SR (1994) The vitamin E nutritional status of rats fed on diets high in fish oil, linseed oil, or sunflower seed oil. British Journal of Nutrition 72, 127145.
Fernandes, G & Venkatraman, JT (1993) Role of omega-3 fatty acids in health and disease. Nutrition Research 13, S19S45.
Fowler, KH, Chapkin, RS & McMurray, DN (1993) Effects of purified dietary n-3 ethyl esters on murine T lymphocyte function. Journal of Immunology 151, 51865197.
Fritsche, KL, Cassity, NA & Huang, S-C (1992) Dietary (n-3) fatty acid and vitamin E interactions in rats: effects on vitamin E status, immune cell prostaglandin E production and primary anti-body response. Journal of Nutrition 122, 10091018.
Fritsche, KL, Shahbazian, LM, Feng, C & Berg, JN (1997) Dietary fish oil reduces survival and impairs bacterial clearance in C3H/ Hen mice challenged with Listeria monocytogenes. Clinical Science 92, 95101.
Goodman, MG & Weigle, WO (1980) Modulation of lymphocyte activation I. Inhibition of an oxidation product of arachidonic acid. Journal of Immunology 125, 593600.
Goodwin, JS, Messner, RP & Peake, GT (1974) Prostaglandin suppression of mitogen stimulated leukocytes in culture. Journal of Clinical Investigation 4, 368378.
Goodwin, JS & Webb, DR (1980) Regulation of the immune response by prostaglandins. Clinical Immunology and Immunopathology 15, 106122.
Gordon, D, Bray, M & Morley, J (1976) Control of Iymphokine secretion by prostaglandins. Nature 262, 401402.
Hollander, D, Dadufabza, VD & Sletten, EG (1984) Does essential fatty acid absorption change with age? Journal of Lipid Research 25, 129134.
Huang, DH, Boudreau, M & Chanmugam, P (1988) Dietary linolenic acid and longer-chain n-3 fatty acids: comparison of effects on arachidonic acid metabolism in rats. Journal of Nutrition 118, 427437.
Hughes, DA & Pinder, AC (1996) Influence of n-3 polyunsaturated fatty acids (PUFA) on the antigen-presenting function of human monocytes. Biochemical Society Transactions 24, 389S.
Hughes, DA, Pinder, AC, Piper, Z, Johnson, IT & Lund, EK (1996 a) Fish oil supplementation inhibits the expression of major histocompatibility complex class I1 molecules and adhesion molecules on human monocytes. American Journal of Clinical Nutrition 63, 267272.
Hughes, DA, Southon, S & Pinder, AC (1996 b) (n-3) Polyunsaturated fatty acids modulate the expression of functionally associated molecules on human monocytes in vitro. Journal of Nutrition 126, 603610.
Hunter, JE (1987) Correspondence: More on fish oil (letter). New England Journal of Medicine 316, 626.
Jolly, CA, Jiang, Y-H, Chapkin, RS& McMurray, DN (1997) Dietary (n-3) polyunsaturated fatty acids suppress murine lympho-proliferation, interleukin-2 secretion, and the formation of diacylglycerol and ceramide. Journal of Nutrition 127, 3743.
Jolly, CA, Laurenz, JC, McMurray, DN & Chapkin, RS (1996) Diacylglycerol and ceramide kinetics in primary cultures of activated T-lymphocytes. Immunology Letters 49, 4348.
Kelley, DS, Nelson, GJ, Serrato, CM, Schmidt, PC & Branch, LB (1988) Effects of type of dietary fat on indices of immune status of rabbits. Journal of Nutrition 118, 13761384.
Knapp, HR (1990) Prostaglandins in human semen during fish oil ingestion: evidence for in vivo cyclooxygenase inhibition and appearance of novel trienoic compound. Prostaglandins 39, 407423.
Knusden, PJ, Dinarello, CA & Strom, TB (1986) Prostaglandins post-transcriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate. Journal of Immunology 137, 31893194.
Kramer, TR, Schoene, N, Dougless, LW, Judd, JT, Ballard-Barbash, R, Taylor, PR, Bhagavan, N & Nair, PP (1991) Increased vitamin E intake restores fish oil-induced suppressed blastogenesis of mitogenic-stimulated T lymphocytes. American Journal of Clinicul Nutrition 54, 896902.
L'Abbe, MR, Trick, KD & Beare-Rogers, J (1991) Dietary (n-3) fatty acids affect rat heart, liver and aorta protective enzyme activities and lipid peroxidation. Journal of Nutrition 121, 13311340.
Leaver, HA, Howie, A & Wilson, NH (1991) The biosynthesis of the 3-series prostaglandins in rat uterus after alpha-linolenic acid feeding, mass spectroscopy of prostaglandins E and F produced by rat uteri in tissue culture. Prostaglandins, Leukotrienes and Essential Fatty Acids 42, 217224.
Lee, TH, Hoover, R, Williams, JD, Sperling, J, Raralese, J, Spur, BW, Robinson, DR, Corey, EJ, Lewis, RA & Austen, KF (1985) Effect of dietary enrichment with eicosapentaenoic and docosa-hexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. New England Journal of Medicine 312, 12171224.
Leitch, AG, Lee, TH, Ringel, EW, Prickett, JD, Robinson, WR, Pyme, SG, Corey, EJ, Drazen, JM, Austen, KF & Lewis, RA (1985) Immunologically induced generation of tetraene and pentaene leukotrienes in the peritoneal cavities of menhaden-fed rats. Journal of Immunology 132, 25592565.
Meydani, M, Natiello, F, Goldin, B, Free, N, Woods, M, Schaefer, E, Blumberg, JB & Gorbach, SL (1991 b) Effect of long-term fish oil supplementation on vitamin E status and lipid peroxidation in women. Journal of Nutrition 121, 484491.
Meydani, SN, Barklund, MP, Liu, S, Meydani, M, Miller, RA, Cannon, JG, Morrow, FD, Rocklin, R & Blumberg, JB (1990) Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. American Journal of Clinical Nutrition 52, 557563.
MeydaniSN, SN,, Endres, S, Woods, MN, Goldin, RD, Soo, C, Morrill-Labrode, A, Dinarello, CA & Gorbach, SL (1991 a) Oral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: Comparison between young and older women. Journal of Nutrition 121, 547555.
Meydani, SN, Lichtenstein, AH, Meydani, M, Goldin, BR, Rasmussen, H, Dinarello, CA & Schaefer, E (1993) Immunologic effects of National Cholesterol Education Panel (NCEP) Step-2 diets with and without fish-derived n-3 fatty acid enrichment. Journal of Clinical Investigation 92, 105113.
Meydani, SN, Meydani, M, Verdon, CP, ShapiroAC, AC,, Blumberg, JB & Hayes, KC (1986) Vitamin E supplementation suppresses prostaglandin E2 synthesis and enhances the immune response of aged mice. Mechanisms of Ageing and Development 34, 191201.
Meydani, SN, Shapiro, AC, Meydani, M, Macauley, JB & Blumberg, JB (1987) Effect of age and dietary fat (fish, corn and coconut oils) on tocopherol status of C57BL/6NIA mice. Lipids 22, 345350.
Meydani, SN, Yogeeswaran, G, Liu, S, Baskar, S & Meydani, M (1988) Fish oil and tocopherol-induced changes in natural killer cell-mediated cytotoxicity and PGE2 synthesis in young and old mice. Journal of Nutrition 118, 12451252.
Miller, RA (1994) Aging and immune function, cellular and biochemical analyses. Experimental Gerontology 29, 2135.
Muggli, R (editor) (1989) Dietary fish oils increase the requirement for vitamin E in humans. St John's, Nfld., Canada: Biochemical Publishers & Distributors.
Payan, DG, Wong, MYS & Chernov-Rogan, T (1986) Alterations in human leukocyte function induced by ingestion of eicosa-pentaenoic acid. Journal of Clinical Immunology 6, 402410.
Piche, LA, Draper, HH & Cole, PD (1988) Malondialdehyde excretion by subjects consuming cod liver oil versus a concentrate of n-3 fatty acids. Lipids 23, 370371.
Plaunt, M (1979) The role of cyclic AMP in modulating cytotoxic T lymphocytes. Journal of Immunology 123, 692701.
Roder, JC & Klein, M (1979) Target-effector interaction in the natural killer cell system. Journal of Immunology 123, 27852790.
Rola-Plezczunski, M (1985) Imunoregulation by leukotrienes and other lipoxygenase metabolites. Immunology Today 6, 302307.
Santoli, D & Zurier, RB (1989) Prostaglandin E precursor fatty acids inhibit human IL-2 production by a prostaglandin E-dependent mechanism. Journal of Immunology 143, 13031309.
Shapiro, AC, Wu, D, Hayek, MG, Meydani, M & Meydani, SN (1994) Role of eicosanoids and vitamin E in fish oil-induced changes of splenocyte proliferation to T cell mitogens in mice. Nutrition Research 14, 13391354.
Shapiro, AC, Wu, D & Meydani, SN (1993) Eicosanoids derived from arachidonic and eicosapentaenoic acids inhibit T cell proliferative response. Prostaglandins 45, 229240.
Simopoulos, AP & Salem, N (1986) Purslane: a terrestrial source of omega-3 fatty acids. New England Journal of Medicine 315, 833.
Siskind, GW (1980) Immunological aspects of aging: An overview. In Biological Mechanism in Aging, pp. 455467 [Schimke, RT, editor]. Bethesda, MA: National Institutes of Health.
Tappia, PS, Man, WJ & Grimble, RF (1995) Influence of unsaturated fatty acids on the production of tumor necrosis factor and interleukin-6 by rat peritoneal macrophages. Molecular and Cellular Biochemistry 143, 8998.
VanMeter, AR, Ehringer, WD, Stillwell, W, Blumenthal, EJ & Jenski, LJ (1994) Aged lymphocyte proliferation following incorporation and retention of dietary omega-3 fatty acids. Mechanisms of Ageing and Development 75, 95114.
Wander, RC, Du, S-H, Ketchum, SO & Rowe, KE (1996) α-Tocopherol influences in vivo indices of lipid peroxidation in postmenopausal women given fish oil. Journal of Nutrition 126, 643652.
Wander, RC, Hall, JA, Gradin, JL, Du, S-H & Jewell, DE (1997) The ratio of dietary (n-6) to (n-3) fatty acids influences immune system function, eicosanoid metabolism, lipid peroxidation, and vitamin E status in aged dogs. Journal of Nutrition 127, 11981205.
Webb, DR, Rogers, TJ & Nowowiejski, E (1980) Endogenous prostaglandin synthesis and the control of lymphocyte function. Proceedings of the New York Academy of Sciences USA 332, 260270.
Whelan, KS, Broughton, B, Lokesh, B & Kinsella, JE (1991) In vivo formation of leukotriene E5 by murine peritoneal cells. Prostaglandins 41, 2941.
Wu, D, Meydani, SN, Meydani, M, Hayek, MG, Huth, P & Nicolosi, RJ (1996) Immunological effects of marine- and plant-derived (n-3) polyunsaturated fatty acids in non-human primates. American Journal of Clinical Nutrition 63, 273280.
Zoschke, DC & Messner, RP (1984) Suppression of human lymphocyte mitogenesis mediated by phagocyte-released reactive oxygen species, comparative activities in normal and chronic granulomatous disease. Clinical Immunology and lmmunopathology 32, 2940.

n-3 Polyunsaturated fatty acids and immune function

  • Dayong Wu (a1) and Simin Nikbin Meydani (a1)


Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed