Apostolova, MD, Ivanova, IA & Cherian, MG (1999) Metallothionein and apoptosis during differentiation of myo- blasts to myotubes: protection against free radical toxicity. Toxicology and Applied Pharmacology 159, 175–184.
Apostolova, MD, Ivanova, IA & Cherian, MG (2000) Signal transduction pathways and nuclear translocation of zinc and metallothionein during differentiation of myoblasts. Biochemistry and Cell Biology 78, 27–37.
Beck, MA (1996) The role of nutrition in viral disease. Nutritional Biochemistry 17, 683–690.
Behne, D, Hilmert, H, Scheid, S, Gessner, H & Elger, W (1998) Evidence for specific selenium target tissues and new biologically important selenoproteins. Biochimica et Biophysica Acta 966, 12–21.
Bermano, G, Arthur, JR & Hesketh, JE (1996) Role of the 3' untranslated region in the regulation of cytosolic glutathione peroxidase and phospholipid-hydroperoxide glutathione peroxidase gene expression by selenium supply. Biochemical Journal 320, 891–895.
Bermano, G, Nicol, F, Dyer, A, Sunde, RA, Beckett, GJ, Arthur, JR & Hesketh, JE (1995) Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats. Biochemical Journal 311, 425–430.
Bernlohr, DA, Coe, NR & Licata, VJ (1999) Fatty acid trafficking in the adipocyte. Seminars in Cell and Developmental Biology 10, 43–49.
Berry, MJ, Banu, L, Chen, YY, Mandel, SJ, Kieffer, JD, Harney, JW & Larsen, PR (1991a) Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3' untranslated region. Nature 353, 273–276.
Berry, MJ, Banu, L, Harney, JW & Larsen, PR (1993) Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons. EMBO Journal 12, 3315–3322.
Berry, MJ, Banu, L & Larsen, PR (1991b) Type-I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature 349, 438–440.
Berry, MJ & Larsen, PR (1993) Recognition of UGA as a selenocysteine codon in eukaryotes: a review of recent progress. Biochemical Society Transactions 21, 827–832.
Berry, MJ, Tujebajeva, RM, Copeland, PR, Xu, XM, Carlson, BA, Martin GW, III, Low, SC, Mansell, JB, Grundner-Culemann, E, Harney, JW, Driscoll, DM & Hatfield, DF (2001) Selenocysteine incorporation directed from the 3'UTR: Characterization of eukaryotic EFsec and mechanistic implications. BioFactors 14, 17–24.
Bremner, I & Beattie, JH (1990) Metallothioneins and the trace minerals. Annual Reviews of Nutrition 10, 63–83.
Brigelius-Flohé, R (1999) Tissue-specific functions of individual glutathione peroxidases. Free Radical Biology and Medicine 27, 951–965.
Brown, KM, Pickard, K, Nicol, F, Beckett, GJ, Duthie, GG & Arthur, JR (2000) Effects of organic and inorganic selenium supplementation on selenoenzyme activity in blood lymphoctyes, granulocytes, platelets and erythrocytes. Clinical Science 98, 593–599.
Chambers, I & Harrison, PR (1987) A new puzzle in selenoprotein biosynthesis - Selenocysteine seems to be encoded by the Stop codon, UGA. Trends In Biochemical Sciences 12, 255–256.
Clark, LC, Combs, GF, Turnbull, BW, Slate, E, Alberts, D, Abele, D, Allison, R, Bradshaw, J, Chalker, D, Chow, J, Curtis, D, Dalen, J, Davis, L, Deal, R & Dellasega, M (1997) The nutritional prevention of cancer with selenium 1983-1993: a randomized clinical trial. Journal of the American Medical Association 276, 1957–1963.
Copeland, PR, Fletcher, JR, Carlson, BA, Hatfield, DL & Driscoll, DM (2000) A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs. EMBO Journal 19, 306–314.
Dalgleish, GD, Veyrune, J-L, Blanchard, J-M & Hesketh, JE (2001) mRNA localization by a 145- nucleotide region of the c-fos 3' untranslated region. Journal of Biological Chemistry 276, 13593–13599.
Desvergne, B & Wahli, W (1999) Peroxisome-proliferator activated receptors: nuclear control of metabolism. Endocrine Review 20, 649–688.
Diamond, AM, Hu, YJ & Mansur, DB (2001) Glutathione peroxidase and viral replication: Implications for viral evolution and chemoprevention. BioFactors 14, 205–210.
Fletcher, JE, Copeland, PR, Driscoll, DM & Krol, A (2001) The selenocysteine incorporation machinery: Interactions between the SECIS RNA and the SECIS-binding protein SBP2. RNA 7, 1442–1453.
Gaub, M-P, Lutz, Y, Ghyselinck, NB, Scheuer, I, Pfister, V, Chambon, P & Rochette-Egly, C (1998) Nuclear detection of cellular retinoic acid binding proteins I and II with new antibodies. Journal of Histochemistry and Cytochemistry 46, 1103–1111.
Gustafson, A-L, Donovan, M, Annerwall, E, Dencker, L & Eriksson, U (1996) Nuclear import of cellular retinoic acid-binding protein type I in mouse embryonic cells. Mechanisms in Development 58, 27–38.
Heider, J, Baron, C & Bock, A (1992) Coding from a distance - Dissection of the messenger - RNA determinants required for the incorporation of selenocysteine into protein. EMBO Journal 11, 3759–3766.
Hentze, MW & Kulozik, AE (1999) A perfect message: RNA surveillance and nonsense-mediated decay. Cell 96, 307–310.
Hesketh, JE, Campbell, GP, Piechaczyk, M & Blanchard, J-M (1994) Targeting of c-myc and ß-globin coding sequences to cytoskeletal-bound polysomes by c-myc 3' untranslated region. Biochemical Journal 298, 143–148.
Hesketh, JE, Vasconcelos, MH & Bermano, G (1998) Regulatory signals in messenger RNA: determinants of nutrient-gene interaction and metabolic compartmentation. British Journal of Nutrition 80, 307–321.
Hill, KE, Lloyd, RS & Burk, RF (1993) Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA. Proceedings of the National Academy of Sciences USA 90, 537–541.
Hu, YJ, Korotkov, KV, Mehta, R, Hatfield, DL, Rotimi, CN, Luke, A, Prewitt, TE, Cooper, RS, Stock, W, Vokes, EE, Dolan, ME, Gladyshev, VN & Diamond, AM (2001) Distribution and functional consequences of nucleotide polymorphisms in the 3'-untranslated region of the human Sep15 gene. Cancer Research 61, 2307–2310.
Hubert, N, Walczak, R, Carbon, P & Krol, A (1996) A protein binds the selenocysteine insertion element in the 3'UTR of mammalian selenoprotein mRNAs. Nucleic Acids Research 24, 464–469.
Kim, IY & Stadtman, TC (1995) Selenophosphate synthetase - Detection in extracts of rat-tissues by immunoblot assay and partial-purification of the enzyme from the archean Methanococcus-Vannielii. Proceedings of the National Academy of Sciences USA 92, 7710–7713.
Kislauskis, EH, Li, Z, Taneja, KL & Singer, RH (1993) Isoform-specific 3'untranslated sequences sort α-cardiac and ß-cytoplasmic actin messenger RNAs to different cytoplasmic compartments. Journal of Cell Biology 123, 165–172.
Kohrle, J, Brigelius-Flohé, R, Bock, A, Gartner, R, Meyer, O & Flohé, L (2000) Selenium in biology: Facts and medical perspectives. Biological Chemistry 381, 849–864.
Koonin, EV, Bork, P & Sander, C (1994) A novel RNA-binding motif in omnipotent suppressor of translation termination, ribosomal-proteins and a ribosome modification enzyme. Nucleic Acids Research 22, 2166–2167.
Lei, XG, Evenson, JK, Thompson, KM & Sunde, RA (1995) Glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase are differentially regulated in rats by dietary selenium. Journal of Nutrition 125, 1438–1446.
Lesoon, A, Metha, A, Singh, R, Chisolm, GM & Driscoll, DM (1997) An RNA-binding protein recognizes a mammalian selenocysteine insertion sequence element required for cotranslational incorporation of selenocysteine. Molecular and Cellular Biology 17, 1977–1985.
Levadoux, M, Mahon, C, Beattie, JH, Wallace, HM & Hesketh, JE (1999) Nuclear import of metallothionein requires its mRNA to be associated with the perinuclear cytoskeleton. Journal of Biological Chemistry 274, 34961–34966.
Levadoux-Martin, M & Hesketh, JE (2002) Localisation of metallothionein in CHO cells requires a 41-nucleotide sequence within the 3' untranslated region. Biochemical Society Transactions (In the Press).
Levadoux-Martin, M, Hesketh, JE, Beattie, JH & Wallace, HM (2001) Influence of metallothionein-1 localisation on its function. Biochemical Journal 355, 473–479.
Low, SC, Grundner-Culemann, E, Harney, JW & Berry, MJ (2000) SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy. EMBO Journal 19, 6882–6890.
Low, SC, Harney, JW & Berry, MJ (1995) Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis. Journal of Biological Chemistry 270, 21659–21664.
Maehira, F, Luyo, GA, Miyagi, I, Oshiro, M, Yamane, N, Kuba, M & Nakazato, Y (2002) Alterations of serum selenium concentrations in the acute phase of pathological conditions. Clinica Chimica Acta 316, 137–146.
Mahon, P, Beattie, JH, Glover, LA & Hesketh, JE (1995) Localisation of metallothionein isoform mRNAs in rat hepatoma (H4) cells. FEBS Letters 373, 76–80.
Mahon, PC, Partridge, K, Beattie, JM, Glover, LA & Hesketh, JE (1997) The 3'untranslated region plays a rôle in the targeting of metallothionein-1 mRNA to the perinuclear cytoplasm and cytoskeletal-bound polysomes. Biochimica et Biophysica Acta 1358, 153–162.
Maquat, LE (2001) Evidence that selenium deficiency results in the cytoplasmic decay of GPX1 mRNA dependent on pre-mRNA splicing proteins bound to the mRNA exon-exon junction. Bio Factors 14, 37–42.
Ministry of Agriculture, Fisheries and Food (1997) Dietary Intake of Selenium. Food Surveillance Information Sheet No. 127. London: H.M. Stationery Office.
Molnar, J, MacPherson, A, Barclay, I & Molnar, P (1995) Selenium content of convenience and fast foods in Ayrshire, Scotland. International Journal of Food Sciences and Nutrition 46, 343–352.
Nagy, E & Maquat, LE (1998) A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance. Trends In Biochemical Sciences 23, 198–199.
Noy, N (2001) Retinoid-binding proteins: mediators of retinoid action. Biochemical Journal 348, 481–495.
Pagmantidis, V, Bermano, G, Broom, I, Arthur, JR & Hesketh, JE (2002) Selenoprotein expression in the rat colon during Se deficiency. Proceedings of Nutrition Society 61, 51A.
Panemangalore, M, Banerjee, D, Onosaka, S & Cherian, MG (1983) Changes in the intracellular accumulation and distribution of metallothionein in rat liver and kidney during postnatal development. Developmental Biology 97, 95–102.
Rayman, MP (2000) The importance of selenium to human health. Lancet 356, 233–241.
Ruff, SJ & Ong, DE (2000) Cellular retinoic acid binding protein is associated with mitochondria. FEBS Letters 487, 282–286.
Salvatore, D, Low, SC, Berry, MJ, Maia, AL, Harney, JW, Croteau, W, St, Germain DL & Larsen, PR (1995) Type-3 iodothyronine deiodinase - Cloning, in-vitro expression, and functional-analysis of the placental selenoenzyme. Journal of Clinical Investigation 96, 2421–2430.
Schmidt, C & Beyersmann, D (1999) Transient peaks in zinc and metallothionein levels during differentiation of 3T3-L1 cells. Archives of Biochemistry and Biophysics 364, 91–98.
Schwarz, K & Foltz, CM (1957) Selenium as an integral part of factor 3 against necrotic dietary liver degeneration. Journal of the American Chemical Society 79, 3292–3293.
Shen, Q, Chu, FF & Newburger, PE (1993) Sequences in the 3'-untranslated region of the human cellular glutathione peroxidase gene are necessary and sufficient for selenocysteine incorporation at the UGA codon. Journal of Biological Chemistry 268, 11463–11469.
Shen, Q, McQuilkin, PA & Newburger, PE (1995) RNA-binding proteins that specifically recognize the selenocysteine insertion sequence of human cellular glutathione peroxidase mRNA. Journal of Biological Chemistry 270, 30448–30452.
Shortt, CT, Duthie, GG, Robertson, JD, Morrice, PC, Nicol, F & Arthur, JR (1997) Selenium status in a group of scottish adults. European Journal of Clinical Nutrition 51, 400–404.
Templeton, DM, Banerjee, D & Cherian, MG (1985) Metallothionein synthesis and localisation in relation to metal storage in rat liver during gestation. Biochemistry and Cell Biology 63, 16–22.
Tsujikawa, K, Imai, T, Kakutani, M, Kayamori, Y, Mimura, Y, Otaki, N, Kimura, M, Fukuyama, R & Shimizu, N (1991) Localization of metallothionein in nuclei of growing primary adult rat hepatocytes. FEBS Letters 283, 239–242.
Tujebajeva, RM, Copeland, PR, Xu, XM, Carlson, BA, Harney, JW, Driscoll, DM, Hatfield, DL & Berry, MJ (2000) Decoding apparatus for eukaryotic selenocysteine insertion. EMBO Reports 1, 158–163.
Venepally, P, Reddy, LG & Sani, BC (1996) Analysis of the effects of CRABPI expression on the RA-induced transcription mediated by retinoid receptors. Biochemistry 35, 9974–9982.
Veyrune, J-L, Campbell, GP, Wiseman, J, Blanchard, J-M & Hesketh, JE (1996) A localisation signal in the 3'untranslated region of c-myc mRNA targets c-myc mRNA and ß-globin reporter sequences to the perinuclear cytoplasm and cytoskeletal- bound polysomes. Journal of Cell Science 109, 1185–1194.
Villette, S, Arthur, JR, Bermano, G & Hesketh, JE (1998) Thyroid stimulating hormone and selenium supply interact to regulate selenoenzyme gene expression in thyroid cells (FRTL-5) in culture. FEBS Letters 438, 81–84.
Villette, S, Kyle, JAM, Brown, KM, Pickard, K, Milne, JS, Nicol, F, Arthur, JR & Hesketh, JE (2002) A novel single nucleotide polymorphism in the 3' untranslated region of human glutathione peroxidase 4 influences lipoxygenase metabolism. Blood cells, Molecules and Disease (In the Press).
Walczak, R, Carbon, P & Krol, A (1998) An essential non-Watson-Crick base pair motif in the 3'UTR to mediate selenoprotein translation. RNA 4, 74–84.
Walczak, R, Westhof, E, Carbon, P & Krol, A (1996) A novel RNA structural motif in the selenocysteine insertion element of eukaryotic selenoprotein mRNAs. RNA 2, 367–369.
Weiss, SL & Sunde, RA (1998) Cis-acting elements are required for selenium regulation of glutathione peroxidase-1 mRNA levels. RNA 4, 816–827.
Wingler, K, Bocher, M, Flohé, L, Kollmus, H & Brigelius-Flohé, R (1999) mRNA stability and selenocysteine insertion sequence efficiency rank gastrointestinal glutathione peroxidase high in the hierarchy of selenoproteins. European Journal of Biochemistry 259, 149–157.
Wingler, K, Muller, C & Brigelius-Flohé, R (2000) Stability of gastrointestinal glutathione peroxidase mRNA in selenium deficiency depends on its 3'UTR. Biofactors 12, 1–8.
Wolfrum, C, Borrmann, CM, Borchers, T & Spener, F (2001) Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors α and γ-mediated gene expression via liver fatty acid binding protein: A signalling pathway to the nucleus. Proceedings of National Academy of Sciences USA 98, 2323–2328.
Woo, ES & Lazo, JS (1997) Nucleocytoplasmic functionality of metallothionein. Cancer Research 57, 4236–4241.
Wu, R, Shen, Q & Newburger, PE (2000) Recognition and binding of the human selenocysteine insertion sequence by nucleolin. Journal of Cellular Biochemistry 77, 507–516.
Yang, G, Chen, J, Wen, Z, Ge, K & Zhu, L (1984) The role of selenium in Keshan disease. Advances in Nutrition Research 6, 203–231.