Hostname: page-component-84b7d79bbc-x5cpj Total loading time: 0 Render date: 2024-07-25T20:26:37.901Z Has data issue: false hasContentIssue false
  • English
  • Français

The insulin-like growth factors in critical illness: pathophysiology and therapeutic potential

Published online by Cambridge University Press:  28 February 2007

Jeff M. P. Holly
Jeff M. P. Holly
Affiliation:
University Department of Medicine, Bristol Royal Infirmary, Bristol BS2 8HW
Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Guest Lecture
Information
Proceedings of the Nutrition Society , Volume 54 , Issue 2 , July 1995 , pp. 591 - 599
Copyright
Copyright © The Nutrition Society 1995

References

Baxter, R. C. (1991). Physiological roles of IGF binding proteins. In Modern Concepts of Insulin-Like Growth Factors, pp. 371–380 [Spencer, E. M., editor]. Oxford: Elsevier Science Publishing Co. Inc.Google Scholar
Baxter, R. C., Bryson, J. M. & Turtle, J. R. (1980). Somatogenic receptors of rat liver: regulation by insulin. Endocrinology 107, 1176–1181.CrossRefGoogle ScholarPubMed
Baxter, R. C. & Martin, J. L. (1989). Structure of the Mr,140,000 growth hormone-dependent insulin-like growth factor binding protein complex: determination by reconstitution and affinity-labelling. Proceedings of the National Academy of Sciences, USA 86, 6898–6902.CrossRefGoogle Scholar
Belcher, H. J. C. R., Mercer, D., Judkins, K. C., Shalaby, S., Wise, S., Marks, V. & Tanner, N. S. B. (1989). Biosynthetic growth hormone in burned patients: a pilot study. Burns 15, 99–107.CrossRefGoogle ScholarPubMed
Binoux, M. & Hossenlopp, P. (1988). Insulin-like growth factor (IGF) and IGF-binding proteins: comparison of human serum and lymph. Journal of Clinical Endocrinology and Metabolism 67, 509–514.CrossRefGoogle ScholarPubMed
Burgess, E. J. (1992). Insulin-like growth factor I: a valid nutritional indicator during parenteral feeding of patients suffering an acute phase response. Annals of Clinical Biochemistry 29, 137–144.CrossRefGoogle ScholarPubMed
Chen, S. A., Bukar, J. G. & Mohler, M. A. (1993). Recombinant human IGF-I infusion results in transient improvement in nitrogen balance. Proceedings of the 75th Annual Meeting of the Endocrine Society, 1546 Abstr.Google Scholar
Clemmons, D. R., Camacho-Hubner, C., Jones, J. I., McCusker, R. H. & Busby, W. H. (1991). Insulin-like growth factor binding proteins: mechanisms of action at the cellular level. In Modern Concepts of Insulin-Like Growth Factors, pp. 475–486 [Spencer, E. M., editor]. Oxford: Elsevier Science Publishing Co. Inc.Google Scholar
Clemmons, D. R., Smith-Banks, A. & Underwood, L. E. (1992). Reversal of diet-induced catabolism by infusion of recombinant insulin-like growth factor-I in humans. Journal of Clinical Endocrinology and Metabolism 75, 234–238.Google ScholarPubMed
Clemmons, D. R. & Underwood, L. E. (1994). Uses of human insulin-like growth factor-I in clinical conditions. Journal of Clinical Endocrinology and Metabolism 79, 4–6.Google ScholarPubMed
Copeland, K. C. & Nair, K. S. (1994). Recombinant human insulin-like growth factor-I increases forearm blood flow. Journal of Clinical Endocrinology and Metabolism 79, 230–232.Google ScholarPubMed
Cwyfan Hughes, S. C., Cotterill, A. M., Molloy, A. R., Cassell, T. B., Braude, N., Hinds, C. J., Wass, J. A. H. & Holly, J. M. P. (1992). The induction of specific proteases for insulin-like growth factor binding proteins following major heart surgery. Journal of Endocrinology 135, 135–145.CrossRefGoogle ScholarPubMed
Cwyfan Hughes, S. C., Donaghy, A. J., Williams, R. & Holly, J. M. P. (1994). IGFBP physiology and the presence of proteolytic activity in a patient following hepatectomy. Growth Regulation 4, Suppl. 1, 91.Google Scholar
Davies, S. C., Wass, J. A. H., Ross, R. J. M., Cotterill, A. M., Buchanan, C. R., Coulson, V. J. & Holly, J. M. P. (1991). The induction of a specific protease for insulin-like growth factor binding protein-3 in the circulation during severe illness. Journal of Endocrinology 130, 469–473.CrossRefGoogle ScholarPubMed
Davenport, M. L., Isley, W. L., Pucilowska, J. B., Pemberton, L. B., Lyman, B., Underwood, L. E. & Clemmons, D. R. (1992). Insulin-like growth factor-binding protein-3 proteolysis is induced after elective surgery. Journal of Clinical Endocrinology and Metabolism 75, 590–595.Google ScholarPubMed
DeChiara, T. M., Efstratiadis, A. & Robertson, E. J. (1990). A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 345, 78–80.CrossRefGoogle ScholarPubMed
Douglas, R. G., Humberstone, D. A., Haystead, A. & Shaw, J. H. F. (1990). Metabolic effects of recombinant human growth hormone: isotopic studies in the postabsorptive state and during total parenteral nutrition. British Journal of Surgery 77, 785–790.CrossRefGoogle ScholarPubMed
Douglas, R. G. & Shaw, J. H. F. (1989). Metabolic response to sepsis and trauma. British Journal of surgery 76, 115–122.CrossRefGoogle ScholarPubMed
Drop, S. L. S., Brinkman, A., Kortleve, D. J., Groffen, C. A. H., Schuller, A. & Zwarthoff, E. C. (1991). The evolution of the insulin-like growth factor binding protein family. In Modern Concepts of Insulin-Like Growth Factors, pp. 311–328 [Spencer, E. M., editor]. Oxford: Elsevier Science Publishing Co. Inc.Google Scholar
Elahi, D., McAloon-Dyke, M. & Fukagawa, N. K. (1991). Hemodynamic and metabolic responses to human insulin-like growth factor I in men. In Modern Concepts of Insulin-Like Growth Factors, pp. 219–224 [Spencer, E. M., editor]. Oxford: Elsevier Science Publishing Co. Inc.Google Scholar
Frayn, K. N., Price, D. A., Maycock, P. F. & Carroll, S. M. (1984). Plasma somatomedin activity after injury in man and its relationship to other hormonal and metabolic changes. Clinical Endocrinology 20, 179–187.CrossRefGoogle ScholarPubMed
Giacca, A., Gupta, R., Efendic, S., Hall, K., Skottner, A., Lickley, L. & Vranic, M. (1990). Differential effects of IGF-I and insulin on glucoregulation and fat metabolism in depancreatized dogs. Diabetes 39, 340–347.CrossRefGoogle ScholarPubMed
Giudice, L. C., Farrell, E. M., Pham, H., Lamson, G. & Rosenfeld, R. G. (1990). Insulin-like growth factor binding proteins in maternal serum throughout gestation and in the puerperium: effects of a pregnancy associated serum protease activity. Journal of Clinical Endocrinology and Metabolism 71, 806–816.CrossRefGoogle ScholarPubMed
Guler, H.-P., Eckardt, K.-U., Zapf, J., Bauer, C. & Froesch, E. R. (1989 a). Insulin-like growth factor I increases glomerular filtration rate and renal plasma flow in man. Acta Endocrinologica 121, 101–106.Google ScholarPubMed
Guler, H.-P., Zapf, J., Schmid, C. & Froesch, E. R. (1989 b). Insulin-like growth factors I and II in healthy man. Estimation of half-lives and production rates. Acta Endocrinologica 121, 753–758.Google Scholar
Han, V. K. M., Lund, P. K., Lee, D. C. & D'Ercole, A. J. (1988). Expression of somatomedin/insulin-like growth factor messenger ribonucleic acids in the human fetus: identification, characterisation, and tissue distribution. Journal of Clinical Endocrinology and Metabolism 66, 422–429.CrossRefGoogle ScholarPubMed
Holly, J. M. P., Claffey, D. C. P., Cwyfan-Hughes, S. C., Frost, V. J. & Yateman, M. E. (1993). Proteases acting on IGFBPs; their occurrence and physiological significance. Growth Regulation 3, 88–91.Google ScholarPubMed
Horber, F. F. & Haymond, M. W. (1990). Human growth hormone prevents protein catabolic side effects of prednisone in humans. Journal of Clinical Investigation 86, 265–272.CrossRefGoogle ScholarPubMed
Hossenlopp, P., Segovia, B., Lassarre, C., Roghani, M., Bredon, M. & Binoux, M. (1990). Evidence of enzymatic degradation of insulin-like growth factor binding proteins in the 150 K complex during pregnancy. Journal of Clinical Endocrinology and Metabolism 71, 797–805.CrossRefGoogle Scholar
Kiefer, M. C., Schmid, C., Waldvogel, M., Schlapfer, I., Futo, E., Masiarz, F. R., Green, K., Barr, P & Zapf, J. (1992). Characterization of recombinant human insulin-like growth factor binding proteins 4, 5, and 6 produced in yeast. Journal of Biological Chemistry 267, 12692–12699.CrossRefGoogle Scholar
Kudsk, D. A., Mowatt Larssen, C., Bukar, J., Fabian, T., Oellerich, S., Dent, D. L. & Brown, R. (1994). Effect of recombinant human insulin-like growth factor I and early total parenteral nutrition on immune depression following severe head injury. Archives of Surgery 129, 66–70.CrossRefGoogle ScholarPubMed
Kupfer, S. R., Underwood, L. E., Baxter, R. C. & Clemmons, D. R. (1993). Enhancement of the anabolic effects of growth hormone and insulin-like growth factor-I by use of both agents simultaneously. Journal of Clinical Investigation 91, 391–396.CrossRefGoogle ScholarPubMed
Lammers, R., Gray, A., Schlessinger, J. & Ullrich, A. (1989). Differential signalling potential of insulin- and IGF-I receptor cytoplasmic domains. EMBO Journal 8, 1369–1375.CrossRefGoogle ScholarPubMed
Lemmey, A. B., Martin, A. A., Read, L. C., Tomas, F. M., Owens, P. C. & Ballard, F. J. (1991). IGF-I and the truncated analogue des-(1–3) IGF-I enhance growth in rats after gut resection. American Journal of Physiology 260, E213–E219.Google ScholarPubMed
Lewitt, M. S., Denyer, G. S., Cooney, G. J. & Baxter, R. C. (1991). Insulin-like growth factor-binding protein-1 modulates blood glucose levels. Endocrinology 129, 2254–2256.CrossRefGoogle ScholarPubMed
Lieberman, S. A., Butterfield, G. E., Harrison, D. & Hoffman, A. R. (1993). Anabolic effects of recombinant insulin-like growth factor I in AIDS-associated cachexia. Proceedings of the 75th Annuai Meeting of the Endocrine Society, 1664 Abstr.Google Scholar
Maes, M., Underwood, L. E. & Ketelslegers, J. M. (1986). Low serum somatomedin C in insulin dependent diabetes: evidence for a postreceptor mechanism. Endocrinology 118, 377–382.CrossRefGoogle ScholarPubMed
Maiter, D. M., Maes, M., Underwood, L. E., Fliesen, T., Gerard, G. & Ketelslegers, J. M. (1988). Early changes in serum concentrations of somatomedin-C induced by dietary protein deprivation: contributions of growth hormone receptor and post-receptor defects. Journal of Endocrinology 118, 113–120.CrossRefGoogle ScholarPubMed
Merimee, T. J., Zapf, J. & Froesch, E. R. (1982). Insulin-like growth factors in fed and fasted states. Journal of Clinical Endocrinology and Metabolism 55, 999–1002.CrossRefGoogle ScholarPubMed
Miell, J. P., Taylor, A. M., Jones, J., Buchanan, C. R., Rennie, J., Sherwood, R., Leicester, R. & Ross, R. J. M. (1992). Administration of human recombinant insulin-like growth factor-I to patients following major gastrointestinal surgery. Clinical Endocrinology 37, 542–551.CrossRefGoogle ScholarPubMed
Moxham, C. P., Duronio, V. & Jacobs, S. (1989). Insulin-like growth factor I receptor β-subunit heterogeneity. Evidence for hybrid tetramers composed of insulin-like growth factor-I and insulin receptor heterodimers. Journal of Biological Chemistry 264, 13238–13244.CrossRefGoogle ScholarPubMed
O'Shea, M. H., Miller, S. F. & Hammerman, M. R. (1993). Effects of IGF-I on renal function in patients with chronic renal failure. American Journal of Physiology 264, F917–F922.Google ScholarPubMed
Phillips, L. S. & Unterman, T. G. (1984). Somatomedin activity in disorders of nutrition and metabolism. Clinical Endocrinology and Metabolism 13, 145–189.CrossRefGoogle ScholarPubMed
Pucilowska, J. B., Davenport, M. L., Kabir, I., Clemmons, D. R., Thissen, J.-P., Butler, T. & Underwood, L. E. (1993). The effect of dietary protein supplementation on insulin-like growth factors (IGFs) and IGF-binding proteins in children with shigellosis. Journal of Clinical Endocrinology and Metabolism 77, 1516–1521.Google ScholarPubMed
Ross, R. J. M., Miell, J., Freeman, E., Jones, J., Matthews, D., Preece, M. & Buchanan, C. (1991 a). Critically ill patients have high basal growth hormone levels with attenuated oscillatory activity associated with low levels of insulin like growth factor-I. Clinical Endocrinology 35, 47–54.CrossRefGoogle ScholarPubMed
Ross, R. J. M., Miell, J. P., Holly, J. M. P., Maheshwari, H., Norman, M., Abdulla, A. F. & Buchanan, C. R. (1991 b). Levels of GH and IGF binding proteins, insulin, blood glucose and cortisol in intensive care patients. Clinical Endocrinology 35, 361–367.CrossRefGoogle ScholarPubMed
Smith, C. P., Dunger, D. B., Williams, A. J. K., Taylor, A. M., Perry, L. A., Gale, E. A. M., Preece, M. A. & Savage, M. O. (1989). Relationship between insulin, insulin-like growth factor I and dehydroepiandrosterone sulfate concentrations during childhood, puberty and adult life. Journal of Clinical Endocrinology and Metabolism 68, 932–937.CrossRefGoogle ScholarPubMed
Snyder, D. K., Clemmons, D. R. & Underwood, L. E. (1988). Treatment of obese, diet restricted subjects with growth hormone for 11 weeks: effects on anabolism, lipolysis and body composition. Journal of Clinical Endocrinology and Metabolism 67, 54–61.CrossRefGoogle ScholarPubMed
Strauss, D. S. & Takemoto, C. D. (1990). Effect of fasting on insulin-like growth factor-I (IGF-I) and growth hormone receptor mRNA levels and IGF-I gene transcription in rat liver. Molecular Endocrinology 4, 91–100.CrossRefGoogle Scholar
Sussenbach, J. S., Steenbergh, P. H., Jansen, E., Meinsma, D., van Dijk, M. A., Holthuizen, P., de Moor, C. H., Jansen, M. & van den Brande, J. L. (1991). Structure and post-transcriptional regulation of expression of the human IGF-I and IGF-II genes. In Modern Concepts of Insulin-like Growth Factors, pp. 639–654 [Spencer, E. M., editor]. Oxford: Elsevier Science Publishing Co. Inc.Google Scholar
Takano, K., Hizuka, N., Shizume, K., Asakawa, K., Fukuda, I. & Demura, H. (1991). Repeated S.C. administration of recombinant human insulin like growth factor-I (IGF-I) to human subjects for seven days. Growth Regulation 1, 23–28.Google Scholar
Taylor, A. M., Dunger, D. B., Preece, M. A., Holly, J. M. P., Smith, C. P., Wass, J. A. H., Patel, S. & Tate, V. E. (1990). The growth hormone independent insulin-like growth factor I binding protein BP-28 is associated with serum insulin-like growth factor-I inhibitory bioactivity in adolescent insulin-dependent diabetics. Clinical Endocrinology 32, 229–239.CrossRefGoogle ScholarPubMed
Timmins, A. G., Blum, W., Holly, J. M. P., Hinds, C. J. & Cotterill, A. M. (1993). Circulating levels of insulin-like growth factor -1, -2, and insulin-like growth factor binding proteins in critical illness. Journal of Endocrinology 139, Suppl., P98 Abstr.Google Scholar
Tsukahara, H., Gordienko, D. V., Tonshoff, B., Gelato, M. C. & Goligorsky, M. S. (1994). Direct demonstration of insulin-like growth factor-I-induced nitric oxide production by endothelial cells. Kidney International 45, 598–604.CrossRefGoogle ScholarPubMed
Unterman, T. G., Vazquez, R. M., Slas, A. J., Martyn, P. A. & Phillips, L. S. (1985). Nutrition and somatomedin. XIII. Usefulness of somatomedin-C in nutritional assessment. American Journal of Medicine 78, 228–234.CrossRefGoogle ScholarPubMed
Woolfson, A. M. J., Heatley, R. V. & Allison, S. P. (1979). Insulin to inhibit protein catabolism after injury. New England Journal of Medicine 300, 14–17.CrossRefGoogle ScholarPubMed