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A heliocentric view of leptin

Published online by Cambridge University Press:  05 March 2007

Gema Frühbeck
Gema Frühbeck*
Affiliation:
Department of Endocrinology, Clínica Universitaria de Navarra and Metabolic Research Laboratory, University of Navarra, 31008 – Pamplona, Spain
*
Corresponding Author: Gema Frühbeck fax +34 948 29 65 00, email gfruhbeck@unav.es
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Abstract

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Leptin is significantly broadening our understanding of the mechanisms underlying neuroendocrine function. Initially, based on a rather static view of the hormone, most investigations focused on the effects of leptin on food intake control and body-weight homeostasis, with attention primarily focused on the implications of leptin as a lipostatic factor and central satiety agent. However, the almost ubiquitous distribution of leptin receptors in peripheral tissues provided a fertile area for investigation and a more dynamic view of leptin started to unfold. This adipocyte-derived circulating peptidic hormone, with a tertiary structure resembling that of members of the long-chain helical cytokine family, has generated an enormous interest in the interaction as well as integration between brain targets and peripheral signals. Considerable evidence for systemic effects of leptin on specific tissues and metabolic pathways indicates that leptin operates both directly and indirectly to orchestrate complex pathophysiological processes. Disentangling the biochemical and molecular mechanisms in which leptin is involved represents one of the major challenges ahead.

Keywords

OB proteinObesityLipolysisReproductionAngiogenesisHypertension
Type
Nutrition Society Medal Lecture
Information
Proceedings of the Nutrition Society , Volume 60 , Issue 3 , August 2001 , pp. 301 - 318
Copyright
Copyright © The Nutrition Society 2001

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