Hostname: page-component-848d4c4894-xfwgj Total loading time: 0 Render date: 2024-07-07T21:38:33.388Z Has data issue: false hasContentIssue false

Epidemiology and the role of antioxidants in preventing coronary heart disease: a brief overview

Published online by Cambridge University Press:  28 February 2007

Rudolph A. Riemersma
Affiliation:
Cardiovascular Research Unit, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XF
Rights & Permissions [Opens in a new window]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Symposium on ‘Antioxidants’
Copyright
Copyright © The Nutrition Society 1994

References

Avogaro, P., Bon, G. B. & Cazzolato, G. (1988). Presence of a modified low-density lipoprotein in humans. Arteriosclerosis 8, 7987.CrossRefGoogle ScholarPubMed
Enström, J. E., Kanim, L. E. & Klein, M. A. (1992). Vitamin C intake and mortality among a sample of the United States population. Epidemiology 3, 194202.CrossRefGoogle ScholarPubMed
Esterbauer, H., Jurgens, G., Quehenberger, O. & Koller, E. (1987). Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes. Journal of Lipid Research 28, 495509.CrossRefGoogle ScholarPubMed
Gaziano, J. M., Manson, J. E., Ridker, P. M., Buring, J. E. & Hennekens, C. H. (1990). Beta carotene therapy for chronic stable angina. Circulation 82, Suppl. III, 201, Abstr. 0796.Google Scholar
Gey, K. F., Moser, U. K., Jordan, P., Stähelin, H. B., Eichholzer, M. & Ludin, E. (1993). Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: epidemiological update with special attention to carotene and vitamin C. American Journal of Clinical Nutrition 57, Suppl. 5, 787S797S.CrossRefGoogle ScholarPubMed
Gey, K. F., Puska, P., Jordan, P. & Moser, U. K. (1991). Inverse correlation between plasma vitamin E and mortality from ischaemic heart disease in cross-cultural epidemiology. American Journal of Clinical Nutrition 53, 326S334S.CrossRefGoogle ScholarPubMed
Gey, K. F., Stähelin, H. B., Puska, P. & Evans, A. (1987). Relationship of plasma level of vitamin C to mortality from ischaemic heart disease. Annals of New York Academy of Sciences 498, 110123.CrossRefGoogle Scholar
Heller, R. F., Chinn, S., Tunstall-Pedoe, H. D. & Rose, G. (1984). How well can we predict heart disease? Findings in the United Kingdom Heart Disease Prevention Project. British Medical Journal 288, 14091411.CrossRefGoogle ScholarPubMed
Hulme, R., Weyers, E., Rowan, T., Reid, D. S. & Hillis, W. S. (1972). Leucocyte ascorbic acid levels after acute myocardial infarction. British Heart Journal 34, 238243.Google Scholar
Kardinaal, A. F. M., Kok, F. J., Ringstad, J., Gomez-Aracena, J., Mazaev, V. P., Kohlmeier, L., Martin, B. C., Ara, A., Kark, J. D., Delgado-Rodriguez, M., Riemersma, R. A., van 't Veer, P., Huttunen, J. K. & Martin-Moreno, J. M. (1993). Antioxidants in adipose tissue and risk of myocardial infarction: The Euramic Study. Lancet 342, 13791384.CrossRefGoogle ScholarPubMed
Knox, E. G. (1973). Ischaemic heart disease mortality and dietary intake of calcium. Lancet i, 14651467.CrossRefGoogle Scholar
Kok, F. J., de Bruin, A. M., Vanmeeren, R., Hoffman, A., van Laar, A., de Bruin, M., Hermus, R. J. J. & Valkenburg, H. A. (1987). Serum selenium, vitamin antioxidants and cardiovascular mortality: a 9-year follow-up study in The Netherlands. American Journal of Clinical Nutrition 45, 462468.CrossRefGoogle ScholarPubMed
Lapidus, L., Andersson, H., Bengtsson, C. & Bosaeus, I. (1986). Dietary habits in relation to incidence of cardiovascular disease and death in women: a 12-year follow-up of participants in the population study of women in Gothenburg, Sweden. American Journal of Clinical Nutrition 44, 444448.CrossRefGoogle ScholarPubMed
Oliver, M. F., Riemersma, R. A., Thomson, M., Fulton, M., Abraham, R. A. & Wood, D. A. (1990). Linoleic acid and coronary heart disease. In Omega-6 Essential Fatty Acid: Pathophysiology and Roles in Clinical Medicine, pp. 121126 [Horrobin, D., editor]. New York: Alan R. Liss Inc.Google Scholar
Palinski, W., Rosenfeld, M. E., Ylä-Herttuala, S., Gurtner, G. C., Socher, S. S., Butler, S. W., Parthasarathy, S., Carew, T. E., Steinberg, D. & Witztum, J. L. (1989). Low-density lipoprotein undergoes oxidative modification in vivo. Proceedings of the National Academy of Sciences, USA 86, 13721376.CrossRefGoogle ScholarPubMed
Ramirez, J. & Flowers, N. C. (1980). Leucocyte ascorbic acid and its relationship to coronary artery disease in man. American Journal of Clinical Nutrition 33, 20792087.CrossRefGoogle ScholarPubMed
Regnström, J., Nilsson, J., Tornvall, P., Landou, C. & Hamsten, A. (1992). Susceptibility to low-density lipoprotein oxidation and coronary atherosclerosis in man. Lancet 339, 11831186.CrossRefGoogle ScholarPubMed
Riemersma, R. A., Oliver, M., Elton, R. A., Alfthan, G., Vertianinen, E., Salo, M., Rubba, P., Mancini, M., Georgi, H., Vuilleumier, J.-P. & Gey, K. F. (1990). Plasma antioxidants and coronary heart disease: vitamins C and E, and selenium. European Journal of Clinical Nutrition 44, 143150.Google Scholar
Riemersma, R. A., Wood, D. A., MacIntyre, C. C. A., Elton, R. A., Gey, K. F. & Oliver, M. F. (1991). Risk of angina pectoris and plasma concentrations of vitamins A, C and E and carotene. Lancet 337, 15.CrossRefGoogle Scholar
Rimm, E. B., Stampfer, M. J., Ascerio, A., Gionannucci, E., Colditz, G. A. & Willett, W. C. (1993). Vitamin E consumption and the risk of coronary heart disease in men. New England Journal of Medicine 328, 14501456.CrossRefGoogle ScholarPubMed
Salonen, J. T., Salonen, R., Penttilä, I., Harranen, J., Jauhiainen, M., Mäenpää, P. H., Alfthan, G. & Puska, P. (1985). Serum fatty acids, apolipoproteins, selenium and vitamin antioxidants and the risk of death from coronary heart disease. American Journal of Cardiology 56, 226231.CrossRefGoogle Scholar
Salonen, J. T., Salonen, R., Seppänen, K., Kantola, M., Parvainen, M., Alfthan, G., Mäenpää, P. H., Taskinen, E. & Rauramaa, R. (1988). Relationship of serum selenium and antioxidants to plasma lipoproteins, platelet aggregability and prevalent ischaemic heart disease in Eastern Finnish men. Atherosclerosis 70, 155160.CrossRefGoogle ScholarPubMed
Salonen, J. T., Ylä-Herttuala, S., Yamamoto, R., Butler, S., Korpela, H., Salonen, R., Nyyssönen, K., Palinski, W. & Witzum, J. L. (1992). Autoantibody against oxidised LDL and progression of carotid atherosclerosis. Lancet 339, 883887.CrossRefGoogle ScholarPubMed
Smith, W. C. S., Tunstall-Pedoe, H., Crombie, I. K. & Tavendale, R. (1989). Concomitants of excess coronary deaths – major risk factor and lifestyle findings from 10 359 men and women in the Scottish Heart Health Study. Scottish Medical Journal 34, 550555.CrossRefGoogle ScholarPubMed
Stampfer, M. J., Hennekens, C. H., Manson, J., Colditz, G. A., Rosner, B. & Willett, W. C. (1993). Vitamin E consumption and the risk of coronary heart disease in man. New England Journal of Medicine 328, 14441449.CrossRefGoogle Scholar
Steinberg, D., Parthasarathy, S., Carew, T. E., Khoo, J. C. & Witztum, J. L. (1989). Beyond cholesterol: modifications of low-density lipoprotein that increases its atherogenicity. New England Journal of Medicine 320, 915924.Google ScholarPubMed
Stringer, M. D., Görög, P. G., Freeman, A. & Kakkar, V. V. (1989). Lipid peroxides and atherosclerosis. British Medical Journal 298, 281284.CrossRefGoogle ScholarPubMed
Wood, D. A., Butler, S., MacIntyre, C., Riemersma, R. A., Thomson, M., Elton, R. A. & Oliver, M. F. (1987). Linoleic and eicosapentaenoic acids in adipose tissue and platelets and risk of coronary heart disease. Lancet i, 177183.CrossRefGoogle Scholar
Ylä-Herttuala, S., Palinski, W., Rosenfeld, M. E., Parthasarathy, S., Carew, T. E., Butler, S., Witztum, J. L. & Steinberg, D. (1989). Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. Journal of Clinical Investigation 84, 10861095.CrossRefGoogle ScholarPubMed
Ylä-Herttuala, S., Rosenfeld, M. E., Parathasarathy, S., Glass, C. K., Sigal, E., Witztum, J. L. & Steinberg, D. (1990). Colocalization of 15-lipoxygenase messenger-RNA and protein with epitopes of oxidized low-density-lipoprotein in microphage-rich areas of atherosclerotic lesions. Proceedings of the National Academy of Sciences, USA 87, 69596963.CrossRefGoogle ScholarPubMed