Hostname: page-component-7c8c6479df-xxrs7 Total loading time: 0 Render date: 2024-03-19T07:12:59.971Z Has data issue: false hasContentIssue false

Associations between vitamin K status and skeletal and cardio-metabolic health indices in 18–64-year-old Irish adults

Published online by Cambridge University Press:  11 September 2015

A. Hayes
Affiliation:
School of Food and Nutritional Sciences, University College Cork, Republic of Ireland
Á. Hennessy
Affiliation:
School of Food and Nutritional Sciences, University College Cork, Republic of Ireland
J. Walton
Affiliation:
School of Food and Nutritional Sciences, University College Cork, Republic of Ireland
B. McNulty
Affiliation:
UCD Institute of Food and Health, University College Dublin, Belfield, Dublin 4, Republic of Ireland
M. Kiely
Affiliation:
School of Food and Nutritional Sciences, University College Cork, Republic of Ireland
A. Flynn
Affiliation:
School of Food and Nutritional Sciences, University College Cork, Republic of Ireland
K.D. Cashman
Affiliation:
School of Food and Nutritional Sciences, University College Cork, Republic of Ireland
A.J. Lucey
Affiliation:
School of Food and Nutritional Sciences, University College Cork, Republic of Ireland
Rights & Permissions [Opens in a new window]

Abstract

Type
Abstract
Copyright
Copyright © The Authors 2015 

This abstract was awarded the prize for best Nutrition Society Irish Section poster original communication.

A high proportion of Irish men and women have mean daily vitamin K intakes which are likely inadequate. For example, we had previously shown that 52 % of a nationally representative sample of the adult Irish population from 1997–1999( Reference Duggan, Cashman and Flynn 1 ) had vitamin K1 intakes below the UK recommended 1 µg/kg body weight( 2 ), and 17 % and 27 % of men and women, respectively, met the current US adequate intakes for vitamin K.( 3 ) This may have consequences for vitamin K status and associated skeletal and non-skeletal health effects. This analysis explored associations between biochemical measures of vitamin K status and a biomarker of bone turnover and with a metabolic syndrome (MetS) risk score, and its component risk factors as defined by the International Diabetes Federation( 4 ). Data [dietary, lifestyle and risk factor] and serum were accessed from the most recent nationally representative sample of Irish adults (National Adult Nutrition Survey 2008–2010) (www.iuna.net). Vitamin K status measures (undercarboxylated osteocalcin [GLU], carboxylated osteocalcin [GLA], and % osteocalcin undercarboxylated [%ucOC]) and carboxy-terminal collagen crosslinks (CTx; bone resorption marker) were measured in 692 adults by immunoassay.

*Adjustment for age, sex, serum 25(OH)D, dietary calcium, smoking, HRT/oral contraception, PTH, BMI, total osteocalcin

**Adjustment for age, sex, smoking and vitamin K intake. NS, non-significant association (P > 0·05)

Serum %ucOC was a significant (P < 0·0001) positive determinant of serum CTx, adjusting for confounders (model explained 48 % variability in serum CTx). Associations with MetS risk factors were driven by age. Surprisingly, in younger adults (<50y), serum %ucOC was significantly (P < 0·05) lower [Median (IQR)38·8 (27·5, 52·5) %] in those with central obesity and an additional MetS risk compared to those with no MetS risk[42·5 (30·4, 59·6) %], accounting for sex, smoking and vitamin K intake.

The pathogenesis for MetS and each of its components is complex and poorly understood. In addition to its role in skeletal health, vitamin K status may influence specific cardio-metabolic risk factors, however, further investigation is warranted to establish a causal relationship.

The project was funded by the Irish Department of Agriculture, Food, and the Marine under its Food for Health Research Initiative (2007–2012).

References

1. Duggan, P, Cashman, KD, Flynn, A et al. (2004) Brit J Nutr. 92: 151–8CrossRefGoogle Scholar
2. Department of Health (1991) Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report on Health and Social Subjects no. 41. London: HM Stationery Office.Google Scholar
3. Institute of Medicine (2001) Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Manganese, Molydenum, Nickel, Silicon, Vanadium and Zinc. Washington DC: National Academy Press.Google Scholar
4. International Diabetes Federation (2006). The IDF consensus worldwide definition of the metabolic syndrome http://www.idf.org/webdata/docs/Metabolic_syndrome_definition.pdf Google Scholar