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The association between selenium status and cognitive decline in very old adults: The Newcastle 85+ Study

Published online by Cambridge University Press:  03 July 2024

G. Perri ,
J. C Mathers ,
C. Martin-Ruiz ,
C. Parker ,
K. Demircan ,
T. S. Chillon ,
L. Schomburg ,
L. Robinson ,
E. J Stevenson  and
G. Terrera
...Show all authors
G. Perri
Affiliation:
Human Nutrition and Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK MRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK MRC, NuBrain: UK Consortium for Optimal Nutrition for Healthy Brain Ageing, Newcastle University, Newcastle upon Tyne, UK
J. C Mathers
Affiliation:
Human Nutrition and Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK MRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
C. Martin-Ruiz
Affiliation:
BioScreening Core Facility, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
C. Parker
Affiliation:
BioScreening Core Facility, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
K. Demircan
Affiliation:
Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, Germany
T. S. Chillon
Affiliation:
Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, Germany
L. Schomburg
Affiliation:
Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, Germany
L. Robinson
Affiliation:
Human Nutrition and Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
E. J Stevenson
Affiliation:
Human Nutrition and Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK MRC, NuBrain: UK Consortium for Optimal Nutrition for Healthy Brain Ageing, Newcastle University, Newcastle upon Tyne, UK
G. Terrera
Affiliation:
Edinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK MRC, NuBrain: UK Consortium for Optimal Nutrition for Healthy Brain Ageing, Newcastle University, Newcastle upon Tyne, UK
F. F Sniehotta
Affiliation:
Population Health Science Institute, Faculty of Medical Sciences, Baddiley-Clark Building Newcastle University, Newcastle upon Tyne, UK
C. Ritchie
Affiliation:
Edinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
A. Adamson
Affiliation:
Human Nutrition and Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK MRC, NuBrain: UK Consortium for Optimal Nutrition for Healthy Brain Ageing, Newcastle University, Newcastle upon Tyne, UK
A. Burns
Affiliation:
Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK MRC, NuBrain: UK Consortium for Optimal Nutrition for Healthy Brain Ageing, Newcastle University, Newcastle upon Tyne, UK
A.M Minihane
Affiliation:
Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, UK MRC, NuBrain: UK Consortium for Optimal Nutrition for Healthy Brain Ageing, Newcastle University, Newcastle upon Tyne, UK
O. Shannon
Affiliation:
Human Nutrition and Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
T.R Hill
Affiliation:
Human Nutrition and Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK MRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK MRC, NuBrain: UK Consortium for Optimal Nutrition for Healthy Brain Ageing, Newcastle University, Newcastle upon Tyne, UK
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Abstract

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The trace element selenium is known to protect against oxidative damage which is known to contribute to cognitive impairment with ageing (1,2). The aim of this study was to explore the association between selenium status (serum selenium and selenoprotein P (SELENOP)) and global cognitive performance at baseline and after 5 years in 85-year-olds living in the Northeast of England.

Serum selenium and SELENOP concentrations were measured at baseline by total reflection X-ray fluorescence (TXRF) and enzyme-linked immunosorbent assay (ELISA), respectively, in 757 participants from the Newcastle 85+ study. Global cognitive performance was assessed using the Standardized Mini-Mental State Examination (SMMSE) where scores ≤25 out of 30 indicated cognitive impairment. Logistic regressions explored the associations between selenium status and global cognition at baseline. Linear mixed models explored associations between selenium status and global cognition prospectively after 5 years. Covariates included sex, body mass index, physical activity, high sensitivity C-reactive protein, alcohol intake, self-rated health, medications and smoking status.

At baseline, in fully adjusted models, there was no increase in odds of cognitive impairment with serum selenium (OR 1.004, 95% CI 0.993-1.015, p = 0.512) or between SELENOP (OR 1.006, 95% CI 0.881-1.149, p = 0.930). Likewise, over 5 years, in fully adjusted models there was no association between serum selenium and cognitive impairment (β 7.20E-4 ± 5.57E-4, p = 0.197), or between SELENOP and cognitive impairment (β 3.50E-3 ± 6.85E-3, p = 0.610).

In this UK cohort of very old adults, serum selenium or SELENOP was not associated with cognitive impairment at baseline and 5 years. This was an unexpected finding despite SELENOP’s key role in the brain and the observed associations in other studies. Further research is needed to explore the effect of selenium on global cognition in very old adults.

Type
Abstract
Information
Proceedings of the Nutrition Society , Volume 83 , Issue OCE2: Winter Conference 2023, 5-6 December 2023, Diet and lifestyle strategies for prevention and management of multimorbidity , June 2024 , E200
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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