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Apolipoprotein B-48 as a marker for chylomicrons and their remnants: Studies in the postprandial state

Published online by Cambridge University Press:  18 April 2008

S. Gail Isherwood
Affiliation:
Nutrition Research Group, University of Surrey, Guildford GU2 5XH
Christine M. Williams
Affiliation:
Nutrition Research Group, University of Surrey, Guildford GU2 5XH
Barry J. Gould
Affiliation:
Nutrition Research Group, University of Surrey, Guildford GU2 5XH
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Abstract

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Type
Postgraduate Symposium
Copyright
Copyright © The Nutrition Society 1997

References

REFERENCES

Aldred, H. E., Hardman, A. E. & Taylor, S. (1995). Influence of 12 weeks of training by brisk walking on postprandial lipemia and insulinemia in sedentary middle-aged women. Metabolism 44, p. 390397.CrossRefGoogle ScholarPubMed
Aldred, H. E., Perry, I. C. & Hardman, A. E. (1994). The effect of a single bout of brisk walking on postprandial lipemia in normolipidemic young adults. Metabolism 43, p. 836841.CrossRefGoogle ScholarPubMed
Arnold, L. M., Ball, M. J., Duncan, A. W. & Mann, J. (1993). Effect of isoenergetic intake of three or nine meals on plasma lipoproteins and glucose metabolism. American Journal of Clinical Nutrition 57, p. 446451.CrossRefGoogle ScholarPubMed
Berr, F. (1992). Characterization of chylomicron remnant clearance by retinyl palmitate label in normal humans. Journal of Lipid Research 33, p. 915930.CrossRefGoogle ScholarPubMed
Blaner, W. S., Obunike, J. C., Kurlandsky, S. B., Al-Haideri, M., Piantedosi, R., Deckelbaum, R. J. & Goldberg, I. J. (1994). Lipoprotein lipase hydrolysis of retinyl ester. Journal of Biological Chemistry 269, p. 1555916565.CrossRefGoogle ScholarPubMed
Brouwer, C. G., de Bruin, T. W. A., Jansen, H. & Erkelens, D. W. (1993). Different clearance of intravenously administered olive oil and soybean-oil emulsions: role of hepatic lipase. American Journal of Clinical Nutrition 57, p. 533539.CrossRefGoogle ScholarPubMed
Chen, Y. D. I., Skowronski, R., Coulston, A. M., Pietarinen, J., Hollenbeck, C. B. & Reaven, G. M. (1992). Effect of acute variations in dietary fat and carbohydrate intake on retinyl ester content of intestinally derived lipoproteins. Journal of Clinical Endocrinology and Metabolism 74, p. 2832.Google Scholar
Chung, B. H. & Segrest, J. P. (1990). Cytotoxicity of triglyceride-rich lipoproteins: an atherogenic insult?. Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia p. 341351 [Malmendier, C. L., Alaupovic, P., Brewer, H. B., editors] New York: Plenum PressCrossRefGoogle Scholar
Cohen, J. C., Noakes, T. D. & Spinnler Benade, A. J. (1988). Serum triglyceride responses to fatty meals: effects of meal fat content. American Journal of Clinical Nutrition 47, p. 825827.Google Scholar
Cohen, J. C., Noakes, T. D. & Spinnler Benade, A. J. (1989). Postprandial lipemia and chylomicron clearance in athletes and in sedentary men. American Journal of Clinical Nutrition 49, p. 443447.CrossRefGoogle ScholarPubMed
Cohn, J. S., Johnson, E. J., Millar, J. S., Cohn, S. D., Milne, R. W., Marcel, Y. L., Russell, R. M. & Schaefer, E. J. (1993). Contribution of apoB-48 and apoB-100 triglyceride-rich lipoproteins (TRL) to postprandial increases in the plasma concentration of TRL triglycerides and retinyl esters. Journal of Lipid Research 34, p. 20332040.CrossRefGoogle ScholarPubMed
de Bruin, T. W. A., Brouwer, C. B., van Linde-Sibenius Trip, M., Jansen, H. & Erkelens, D. W. (1993). Different postprandial metabolism of olive oil and soybean oil: a possible mechanism of the high-density lipoprotein conserving effect of olive oil. American Journal of Clinical Nutrition 58, p. 477483.CrossRefGoogle ScholarPubMed
Fabry, P. & Tepperman, J. (1970). Mean frequency - a possible factor in human physiology. American Journal of Clinical Nutrition 23, p. 10591068.CrossRefGoogle Scholar
Floren, C. H., Albers, J. J. & Bierman, E. L. (1981). Uptake of chylomicron remnants causes cholesterol accumulation in cultured human arterial smooth muscle cells. Biochimica et Biophysica Acta 663, p. 336349.CrossRefGoogle ScholarPubMed
Ginsberg, H. N., Jones, J., Blaner, W. S., Thomas, A., Karmally, W., Fields, L., Blood, D. & Begg, M. D. (1995). Association of postprandial trigiyceride and retinyl palmitate responses with newly diagnosed exercise induced myocardial ischaemia in middle-aged men and women. Arteriosclerosis and Thrombosis 15, p. 18291838.CrossRefGoogle ScholarPubMed
Groot, P. H. E., Van Stiphout, W. A. H. J., Krauss, X. H., Jansen, H., Van Tol, A., Van Ramshorst, E., Chin-On, S., Hofman, A., Cresswell, S. R. & Havekes, L. (1991). Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease. Arteriosclerosis and Thrombosis 11, p. 653662.CrossRefGoogle ScholarPubMed
Hardman, A. E. & Aldred, H. E. (1995). Walking in the postprandial period decreases alimentary lipaemia. Journal of Cardiovascular Risk 2, p. 7178.Google Scholar
Harris, W. S., Connor, W. E., Alam, N. & Illingworth, D. R. (1988). Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids. Journal of Lipid Research 29, p. 14511460.CrossRefGoogle ScholarPubMed
Isherwood, S. G. (1996). Apolipoprotein B-48 as a marker for chylomicrons and their remnants; studies in the postprandial state. PhD Thesis, University of Surrey.Google Scholar
Isherwood, S. G., Sethi, S., Gould, B. J., Howland, R. J. & Williams, C. M. (1994). The effects of exercise on postprandial lipaemia: apo B-48 and retinyl palmitate as markers of chylomicron particles. Proceedings of the Nutrition Society 53, 163A.Google Scholar
Isherwood, S. G., Williams, C. M., Griffin, B. A. & Gould, B. J. (1996). Potentially atherogenic chylomicron remnants are present in the low-density-lipoprotein fraction as detected by a specific antibody to apolipoprotein B-48. Proceedings of the Nutrition Society 55, 113A.Google Scholar
Jackson, K. G., Lovegrove, J. A., Zampelas, A., Kafatos, A., Kapsokefalou, M., Williams, C. M. & Gould, B. J. (1996). Apolipoprotein B-48 and retinyl ester responses to meals of varying monounsaturated fatty acid contents. Proceedings of the Nutrition Society 55, 112A.Google Scholar
Jenkins, D. J. A., Wolever, T. M. S., Vuskan, V., Brighenti, R., Cunnane, S. C., Rao, A. V., Jenkins, A. L., Buckley, G., Patten, R., Singer, W., Corey, P. & Josse, R. G. (1989). Nibbling versus gorging: metabolic advantages of increased meal frequency. New England Journal of Medicine 321, p. 929934.CrossRefGoogle ScholarPubMed
Kane, J. P., Hardman, D. A. & Paulus, H. E. (1980). Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons. Proceedings of the National Academy of Sciences USA 77, p. 24652469.CrossRefGoogle ScholarPubMed
Karpe, F. & Hamsten, A. (1994). Determination of apolipoproteins B-48 and B-100 in triglyceride-rich lipoproteins by analytical SDS-PAGE. Journal of Lipid Research 35, p. 13111317.CrossRefGoogle ScholarPubMed
Karpe, F. & Hultin, M. (1995). Endogenous triglyceride-rich lipoproteins accumulate in rat plasma when competing with a chylomicron-like triglyceride emulsion for a common lipolytic pathway. Journal of Lipid Research 36, p. 15571566.CrossRefGoogle ScholarPubMed
Karpe, F., Steiner, G., Uffelman, K., Olivecrona, T. & Hamsten, A. (1994). Postprandial lipoproteins and progression of coronary atherosclerosis. Atherosclerosis 106, p. 8397.CrossRefGoogle ScholarPubMed
Kotite, L., Bergeron, N. & Havel, R. J. (1995). Quantification of apolipoproteins B-100, B-48, and E in human triglyceride-rich lipoproteins. Journal of Lipid Research 36, p. 890900.CrossRefGoogle Scholar
Krasinski, S. D., Cohn, J. S., Russell, R. M. & Schaefer, E. J. (1990). Postprandial plasma vitamin A metabolism in humans: a reassessment of the use of plasma retinyl esters as markers for intestinally derived chylomicrons and their remnants. Metabolism 39, p. 357365.CrossRefGoogle ScholarPubMed
Lovegrove, J. A., Isherwood, S. G., Jackson, K. G., Williams, C. M. & Gould, B. J. (1996). Quantitation of apolipoprotein B-48 in triacylglycerol-rich lipoproteins by a specific enzyme-linked immunosorbent assay. Biochimica et Biophysica Acta 1301, p. 221229.CrossRefGoogle ScholarPubMed
Mamo, J. C. L. & Wheeler, J. R. (1994). Chylomicrons or their remnants penetrate rabbit thoracic aorta as efficiently as do smaller macromolecules, including low density lipoprotein, high density lipoprotein, and albumin. Coronary Heart Disease 5, p. 695705.CrossRefGoogle ScholarPubMed
Mankowitz, K., Seip, R., Semenkovich, C. F., Daugherty, A. & Schonfeld, G. (1992). Short-term interruption of training affects both fasting and post-prandial lipoproteins. Atherosclerosis 95, p. 181189.Google Scholar
Merrill, J. R., Holly, R. G., Anderson, R. L., Rifai, N., King, M. E. & DeMeersman, R. (1989). Hyperlipemic response of young trained and untrained men after a high fat meal. Arteriosclerosis 9, p. 217223.CrossRefGoogle ScholarPubMed
Miesenbock, G. & Patsch, J. R. (1991). Coronary artery disease: synergy of triglyceride-rich lipoproteins and HDL. Cardiovascular Risk Factors 1, p. 293299.Google Scholar
Murphy, M. C., Chapman, C., Lovegrove, J. A., Isherwood, S. G., Morgan, L. M., Wright, J. W. & Williams, C. M. (1996). Meal frequency: does it determine postprandial lipaemia?. European Journal of Clinical Nutrition 50, p. 491497.Google ScholarPubMed
Murphy, M. C., Isherwood, S. G., Sethi, S., Gould, B. J., Wright, J. W., Knapper, J. M. E. & Williams, C. M. (1995). Postprandial lipid and hormone responses to meals of varying fat contents: modulatory role of lipoprotein lipase?. European Journal of Clinical Nutrition 49, p. 579588.Google ScholarPubMed
Patsch, J. R., Karlin, J. B., Scott, L. W., Smith, L. C., Gotto, A. M. Jr (1983). Inverse relationship between blood levels of high density lipoprotein subfraction 2 and magnitude of postprandial lipemia. Proceedings of the National Academy of Sciences USA 80, p. 14491453.CrossRefGoogle ScholarPubMed
Peel, A. S., Komanduri, P., Williams, C. M., Morgan, L. M. & Gould, B. J. (1992). A specific antibody to apolipoprotein B-48: a novel approach. Biochemical Society Transactions 20, 165S.CrossRefGoogle ScholarPubMed
Peel, A. S., Zampelas, A., Williams, C. M. & Gould, B. J. (1993). A novel antiserum specific to apolipoprotein B-48: application in the investigation of postprandial lipidaemia in humans. Clinical Science 85, p. 521524.CrossRefGoogle ScholarPubMed
Podl, T. R., Zmuda, J. M., Yurgalevitch, S. M., Fahrenbach, M. C., Bausserman, L. L., Terry, R. B. & Tnompson, P. D. (1994). Lipoprotein lipase activity and plasma triglyceride clearance are elevated in endurance-trained women. Metabolism 43, p. 808813.CrossRefGoogle ScholarPubMed
Rapp, J. H., Lespine, A., Hamilton, R. L., Colyvas, N., Chaumeton, A. H., Tweedie-Hardman, J., Kotite, L., Kunitake, S. T., Havel, R. J. & Kane, J. P. (1994). Triglyceride-rich lipoproteins isolated by selected-affinit anti-apolipoprotein B immunosorption from human atherosclerotic plaque. Arteriosclerosis and Thrombosis 14, p. 17671774.CrossRefGoogle ScholarPubMed
Schneeman, B. O., Kotite, L., Todd, K. M. & Havel, R. J. (1993). Relationships between the responses of triglyceride-rich lipoproteins in blood plasma containing apolipoproteins B-48 and B-100 to a fat-containing meal in normolipidemic humans. Proceedings of the National Academy of Sciences USA 90, p. 20692073.CrossRefGoogle ScholarPubMed
Simpson, H. S., Williamson, C. M., Olivecrona, T., Pringle, S., Maclean, J., Lorimer, A. R., Bonnefous, F., Bogaievsky, Y., Packard, C. J. & Shepherd, J. (1990). Postprandial lipemia, fenofibrate and coronary artery disease. Atherosclerosis 85, p. 193202.CrossRefGoogle ScholarPubMed
Tall, A. R. (1993). Plasma cholesteryl ester transfer protein. Journal of Lipid Research 34, p. 12551274.CrossRefGoogle ScholarPubMed
Uiterwaal, C., Grobbee, D., Witteman, J., van Stiphout, W., Krauss, X., Havekas, L., de Bruijn, A., van Tol, A. & Hofman, A. (1994). Postprandial triglyceride response in young adult men and familial risk from coronary atherosclerosis. Annals of Internal Medicine 121, p. 576583.CrossRefGoogle ScholarPubMed
Weintraub, M. S., Eisenberg, S. & Breslow, J. L. (1987). Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Journal of Clinical Investigation 79, p. 11101119.CrossRefGoogle ScholarPubMed
Weintraub, M. S., Rosen, Y., Otto, R., Eisenberg, S. B. & Eslow, J. L. (1989). Physical exercise conditioning in the absence of weight loss reduces fasting and postprandial triglyceride-rich lipoprotein levels. Circulation 79, p. 10071014.CrossRefGoogle ScholarPubMed
Weintraub, M. S., Zechner, R., Brown, A., Eisenberg, S. & Breslow, J. L. (1988). Dietary polyunsaturated fats of the ω-6 and ω-3 series reduce postprandial lipoprotein levels. Journal of Clinical Investigation 82, p. 18841893.CrossRefGoogle Scholar
Williams, C. M., Moore, F., Morgan, L. M. & Wright, J. (1992). Effects of n-3 fatty acids on postprandial triacylglycerol and hormone concentrations in normal subjects. British Journal of Nutrition 69, p. 6378.Google Scholar
Young, S. G. (1990). Recent progress in understanding apolipoprotein B. Circulation 82, p. 15741594.CrossRefGoogle ScholarPubMed
Zampelas, A., Knapper, J. M. E., Jackson, K. G., Culverwell, C. C., Wilson, J., Gould, B. J. & Williams, C. M. (1995). Postprandial triacylglycerol and apolipoprotein B-48 responses to meals of varying monounsaturated fatty acid content in young UK subjects. Atherosclerosis 115 Suppl., S46.CrossRefGoogle Scholar
Zampelas, A., Peel, A. S., Gould, B. J., Wright, J. & Williams, C. M. (1994). Polyunsaturated fatty acids of the n-6 and n–3 series: effects on postprandial lipid and apolipoprotein levels in healthy men. European Journal of Clinical Nutrition 48, p. 842848.Google Scholar
Zilversmit, D. B. (1979). Atherogenesis: a postprandial phenomenon. Circulation 60, p. 473–185.CrossRefGoogle ScholarPubMed