There is a growing interest in the use of lesser known plant seeds as sources of protein in monogastric feeding in the tropics. It is thought that the exploitation of novel seeds which are currently not utilized by man can contribute to the amelioration of the insufficient feed supply situation in tropical countries like Nigeria. The seeds of Manihot esculenta (Cassava) have the potential to complement the conventional plant protein in poultry diets. Lack of information on the nutritional quality and digestibility of the protein and amino acids in the seeds has caused a limitation in their use for poultry feeding. The objectives of this study were 1) to investigate the chemical and antinutritional constituents in the seeds of Manihot esculenta, and 2) to determine the precaecal digestibility of crude protein (CP) and amino acids (AAs) in the seeds with broilers and their effect on the performance of the birds.