Hostname: page-component-848d4c4894-89wxm Total loading time: 0 Render date: 2024-07-05T05:07:42.507Z Has data issue: false hasContentIssue false

Use of chick embryo infections for the study of drug resistance in Eimeria tenella

Published online by Cambridge University Press:  06 April 2009

H. D. Chapman
Affiliation:
Houghton Poultry Research Station, Houghton, Huntingdon

Extract

The activity of 12 anticoccidial drugs against an embryo-adapted strain of Eimeria tenella has been investigated. After seven and five serial passages respectively, in the presence of drug, resistance was developed to methyl benzoquate and buquinolate. A strain of E. tenella made resistant by exposure to drugs in chickens was resistant to the same drugs when evaluated in infections of chick embryos. This relatively simple technique would appear to offer advantages over existing methods for the study of drug resistance.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1974

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Long, P. L. (1970 a). Eimeria tenella: chemotherapeutic studies in chick embryos with a description of a new method (chorioallantoic membrane foci counts) for evaluating infections. Zeitschrift für Parasitenkunde 33, 329–38.CrossRefGoogle ScholarPubMed
Long, P. L. (1970 b). Some factors affecting the severity of infection with Eimeria tenella in chicken embryos. Parasitology 60, 435–47.CrossRefGoogle ScholarPubMed
Long, P. L. (1972). Eimeria tenella: reproduction, pathogenicity and immunogenicity of a strain maintained in chick embryos by serial passage. Journal of Comparative Pathology and Therapeutics 82, 429–37.Google Scholar
Long, P. L. & Millard, B. J. (1973). Eimeria infection of chicken embryos: The effect of known anticoccidial drugs against E. tenella and E. mivati. Avian Pathology 2, 111–25.CrossRefGoogle ScholarPubMed
McDougald, L. R. & Galloway, R. B. (1973). Eimeria tenella: anticoccidial drug activity in cell cultures. Experimental Parasitology 34, 189–96.CrossRefGoogle ScholarPubMed
McLoughlin, D. K. (1970). Efficacy of buquinolate against ten strains of Eimeria tenella and the development of a resistant strain. Avian Diseases 14, 126–30.Google Scholar
McLoughlin, D. K. & Chute, M. B. (1971). Efficacy of decoquinate against eleven strains of Eimeria tenella and development of a decoquinate resistant strain. Avian Diseases 15, 342–5.CrossRefGoogle ScholarPubMed
McLoughlin, D. K. & Chute, M. B. (1973). Efficacy of clopidol against twelve strains of Eimeria tenella, and the development of a clopidol resistant strain. Avian Diseases 17, 425–9.CrossRefGoogle ScholarPubMed
McLoughlin, D. K. & Gardiner, J. L. (1968). Drug resistance in Eimeria tenella. VI. The experimental development of an amprolium resistant strain. Journal of Parasitology 54, 582–4.Google Scholar
McManus, E. C., Campbell, W. C. & Cuckler, A. C. (1968). Development of resistance to quinoline coccidiostats under field and laboratory conditions. Journal of Parasitology 54, 1190–3.CrossRefGoogle ScholarPubMed
Ryley, J. F. (1968). Chick embryo infections for the evaluation of anticoccidial drugs. Parasitology 58, 215–20.Google Scholar
Ryley, J. F. & Betts, M. J. (1973). Chemotherapy of chicken coccidiosis. Advances in Pharmacology and Chemotherapy 11, 221–93.CrossRefGoogle ScholarPubMed