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Transplantation of Hymenolepis diminuta into naive, immune and irradiated mice

Published online by Cambridge University Press:  06 April 2009

C. A. Hopkins  and
A. Zajac
C. A. Hopkins
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Glasgow, G61 1QH.
A. Zajac
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Glasgow, G61 1QH.
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Summary

Almost 100% of 7- to 10-day-old Hymenolepis diminuta became established when surgically transplanted from donor mice into the duodenum of naive recipient mice. Transplanted tapeworms survived 8–12 days, by which time they had survived much longer in total than they would have done in the donor. Mice previously immunized by a primary infection rejected transplants within 4 days. Sub-lethal irradiation (550 rad) delayed rejection by immune mice but such mice still rejected worms much more quickly than did naive mice.

Surgery was shown to delay by 2–3 days the rejection of worms by naive mice, and the importance of circumventing surgery by administering the worms per os is emphasized.

Prospects for reconstituting irradiated immune mice are considered vis-à-vis work with nematodes, and the differences which, on present knowledge, appear to exist between nematode and cestode rejection are briefly discussed.

Type
Research Article
Information
Parasitology , Volume 73 , Issue 1 , August 1976 , pp. 73 - 81
Copyright
Copyright © Cambridge University Press 1976

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