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The transfer of IgA from mucus to plasma and the implications for diagnosis and control of nematode infections

Published online by Cambridge University Press:  13 February 2014

JOAQUÍN PRADA JIMÉNEZ DE CISNEROS ,
LOUISE MATTHEWS ,
COLETTE MAIR ,
THORSTEN STEFAN  and
MICHAEL J. STEAR
JOAQUÍN PRADA JIMÉNEZ DE CISNEROS*
Affiliation:
Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow G61 1QH, UK
LOUISE MATTHEWS
Affiliation:
Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow G61 1QH, UK
COLETTE MAIR
Affiliation:
Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow G61 1QH, UK
THORSTEN STEFAN
Affiliation:
Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow G61 1QH, UK
MICHAEL J. STEAR
Affiliation:
Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow G61 1QH, UK
*
*Corresponding author: Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow G61 1QH, UK. E-mail: Joaquin.Prada@glasgow.ac.uk
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Summary

Immunoglobulin A (IgA) activity has been associated with reduced growth and fecundity of Teladorsagia circumcincta. IgA is active at the site of infection in the abomasal mucus. However, while IgA activity in abomasal mucus is not easily measured in live animals without invasive methods, IgA activity can be readily detected in the plasma, making it a potentially valuable tool in diagnosis and control. We used a Bayesian statistical analysis to quantify the relationship between mucosal and plasma IgA in sheep deliberately infected with T. circumcincta. The transfer of IgA depends on mucosal IgA activity as well as its interaction with worm number and size; together these account for over 80% of the variation in plasma IgA activity. By quantifying the impact of mucosal IgA and worm number and size on plasma IgA, we provide a tool that can allow more meaningful interpretation of plasma IgA measurements and aid the development of efficient control programmes.

Keywords

ModellingTeladorsagia circumcintaparasiteimmunoglobulin Asheepimmunology
Type
Research Article
Information
Parasitology , Volume 141 , Issue 7 , June 2014 , pp. 875 - 879
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Copyright
Copyright © Cambridge University Press 2014 

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References

REFERENCES

Armour, J., Jarrett, W. F. H. and Jennings, F. W. (1966). Experimental Ostertagia circumcincta infections in sheep: development and pathogenesis of a single infection. American Journal of Veterinary Research 27, 1267–1278.Google Scholar
Balic, A., Bowles, V. M., Liu, Y. S. and Meeusen, E. N. T. (2003). Local immune responses in sensitized sheep following challenge infection with Teladorsagia circumcincta . Parasite Immunology 25, 375–381.CrossRefGoogle ScholarPubMed
Beh, K. J., Watson, D. L. and Lascelles, A. (1974). Concentrations of immunoglobulins and albumin in lymph collected from various regions of the body of the sheep. Australian Journal of Experimental Biology and Medical Science 52, 81–86.CrossRefGoogle ScholarPubMed
Curtis, J. and Bourne, F. J. (1973). Half-lives of immunoglobulins IgG, IgA and IgM in the serum of new-born pigs. Immunology 24, 147–155.Google Scholar
Faraway, J. J. (2006). Extending the Linear Model with R. Chapman & Hall/CRC, Boca Raton, FL, USA.Google Scholar
Gelman, A., Carling, J. B., Stern, H. S. and Rubin, D. B. (2004). Bayesian Data Analysis. Chapman & Hall/CRC, Boca Raton, FL, USA.Google Scholar
Henderson, N. G. and Stear, M. J. (2006). Eosinophil and IgA responses in sheep infected with Teladorsagia circumcincta . Veterinary Immunology and Immunopathology 112, 62–66.Google Scholar
Martinez-Valladares, M., Vara-Del Rio, M. P., Cruz-Rojo, M. A. and Rojo-Vazquez, F. A. (2005). Genetic resistance to Teladorsagia circumcincta: IgA and parameters at slaughter in Churra sheep. Parasite Immunology 27, 213–218. doi: 10.1111/j.1365-3024.2005.00769.x.Google Scholar
Murphy, L., Eckersall, P. D., Bishop, S. C., Pettit, J. J., Huntley, J., Burchmore, R. and Stear, M. J. (2010). Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta . Parasitology 137, 1249–1260.Google Scholar
Plummer, M. (2003). JAGS: a program for analysis of Bayesian graphical models using Gibbs sampling. Proceedings of the 3rd International Workshop on Distributed Statatistical Computing, DSC 2003.Google Scholar
R Development Core Team (2011). R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria.Google Scholar
Shaw, R. J., Morris, C. A. and Wheeler, M. (2013). Genetic and phenotypic relationships between carbohydrate larval antigen (CarLA) IgA, parasite resistance and productivity in serial samples taken from lambs after weaning. International Journal of Parasitology 43, 661–667. doi: 10.1016/j.ijpara.2013.03.003.CrossRefGoogle ScholarPubMed
Singleton, D. R., Stear, M. J. and Matthews, L. (2011). A mechanistic model of developing immunity to Teladorsagia circumcincta infection in lambs. Parasitology 138, 322–332.Google Scholar
Sinski, E., Bairden, K., Duncan, J. L., Eisler, M. C., Holmes, P. H., McKellar, Q. A., Murray, M. and Stear, M. J. (1995). Local and plasma antibody-responses to the parasitic larval stages of the abomasal nematode Ostertagia circumcincta . Veterinary Parasitology 59, 107–118.Google Scholar
Snoeck, V., Peters, I. R. and Cox, E. (2006). The IgA system: a comparison of structure and function in different species. Veterinary Research 37, 455–467. doi: 10.1051/vetres:2006010.CrossRefGoogle ScholarPubMed
Spiegelhalter, D. J., Best, N. G., Carlin, B. R. and van der Linde, A. (2002). Bayesian measures of model complexity and fit. Journal of the Royal Statistics Society Series B – Statistics Methodology 64, 583–616.Google Scholar
Stear, M. J., Bishop, S. C., Doligalska, M., Duncan, J. L., Holmes, P. H., Irvine, J., McCririe, L., McKellar, Q. A., Sinski, E. and Murray, M. (1995). Regulation of egg production, worm burden, worm length and worm fecundity by host responses in sheep infected with Ostertagia circumcincta . Parasite Immunology 17, 643–652.Google Scholar
Stear, M. J., Bairden, K., Bishop, S. C., Gettinby, G., McKellar, Q. A., Park, M., Strain, S. A. J. and Wallace, D. S. (1998). The processes influencing the distribution of parasitic nematodes among naturally infected lambs. Parasitology 117, 165–171.Google Scholar
Stear, M. J., Bishop, S. C., Henderson, N. G. and Scott, I. (2003). A key mechanism of pathogenesis in sheep infected with the nematode Teladorsagia circumcincta . Animal Health Research Reviews 4, 45–52.Google Scholar
Stear, M. J., Singleton, D. R. and Matthews, L. (2011). An evolutionary perspective on gastrointestinal nematodes of sheep. Journal of Helminthology 85, 113–120.Google Scholar
Strain, S. A. J. (2001). Immunity to abomasal parasites in lambs. Ph.D. thesis, Department of Veterinary Pre-Clinical Studies, University of Glasgow, Glasgow.Google Scholar
Strain, S. A. J., Bishop, S. C., Henderson, N. G., Kerr, A., McKellar, Q. A., Mitchell, S. and Stear, M. J. (2002). The genetic control of IgA activity against Teladorsagia circumcincta and its association with parasite resistance in naturally infected sheep. Parasitology 124, 545–552.Google Scholar