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Temporal study of acquired resistance in infections of mice with Giardia muris

Published online by Cambridge University Press:  06 April 2009

M. Belosevic  and
G. M. Faubert
M. Belosevic
Affiliation:
Institute of Parasitology, McGill University, Macdonald Campus, Lakeshore Road, Ste-Anne de Bellevue, Quebec, Canada H9X 1C0
G. M. Faubert
Affiliation:
Institute of Parasitology, McGill University, Macdonald Campus, Lakeshore Road, Ste-Anne de Bellevue, Quebec, Canada H9X 1C0
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Summary

Swiss CD-1 mice infected with cysts of Giardia muris are protected against a challenge infection. A temporal study of this phenomenon was undertaken using two different approaches. First, the time needed for mice to acquire resistance was assessed by terminating the first infection using metronidazole on days 3, 6, 12, 24 or 48. These animals received a challenge infection 7 days later. Second, the duration of the protection was determined by giving mice a challenge infection on days 30, 60, 90, 120 or 150 after the primary infection. In all cases, a significant reduction in both cyst output and trophozoite numbers in the small intestine was observed after challenge. The reduction in cyst output following challenge was similar to the reduction in trophozoite numbers. The acquired resistance of some inbred strains of mice to G. muris was similar to that of CD-1 Swiss mice. These results show that mice can acquire a significant resistance against G. muris even after a short period of contact with the parasite (3 days) and that the resistance may last up to 21 weeks.

Type
Research Article
Information
Parasitology , Volume 87 , Issue 3 , December 1983 , pp. 517 - 524
Copyright
Copyright © Cambridge University Press 1983

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References

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