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Studies on the immunity of sheep to Oesophagostomum columbianum: effects of different and successive doses of larvae on worm burdens, worm growth and fecundity

Published online by Cambridge University Press:  06 April 2009

Colin Dobson
Colin Dobson
Affiliation:
Department of Parasitology, University of Queensland, St Lucia, Brisbane, Queensland, 4067, Australia
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Extract

The effects of different and repeated doses of Oesophagostomum columbianum larvae on the survival of the adult parasite, its length and the fecundity of the female worm in sheep were studied. Adult worm burdens were dependent on the numbers of larvae administered when sheep were infected once, but not when they were infected twice. It was concluded that these effects were caused by non-specific elimination of worms following a single infection, related to competition for space among larvae and to inflammatory reactions stimulated by them in the gut mucosa which increased with the numbers of larvae given. When sheep were infected once with large numbers of larvae or when they were infected twice the surviving adult population was also influenced by the adaptive immune responses of the host. Parasites recovered from sheep given a single infection of 5000 larvae were stunted compared with worms from sheep given fewer larvae. After a second infection all the worms were stunted and the females produced fewer eggs than did female worms following a single infection; but the numbers of larvae administered did not influence these effects. Egg production was also delayed after a second infection. The reduced fecundity of female worms in the immune host was not related to stunting of the worms, because stunted female worms from sheep infected once with 5000 larvae produced as many eggs as females from sheep infected once with smaller numbers of larvae. It is suggested that the different manifestations of protective immunity in sheep were elicited when threshold levels of infection were exceeded. These levels were represented by between 2000 and 5000 larvae in first, and fewer than 500 larvae in second infections.

Type
Research Article
Information
Parasitology , Volume 68 , Issue 3 , June 1974 , pp. 313 - 322
Copyright
Copyright © Cambridge University Press 1974

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References

REFERENCES

Africa, C. M., (1931). Studies on the host relations of Nippostrongylus muris with special reference to age resistance and acquired immunity. Journal of Parasitology 18, 1–13.CrossRefGoogle Scholar
Bawden, R. J., (1969). Relationship between Oesophagostomum columbianum infection and nutritional status of sheep. I. Effect on growth and feed utilization. Australian Journal of Agricultural Research 20, 589–99.CrossRefGoogle Scholar
Brambell, M. R., (1965). The distribution of a primary infestation of Nippostrongylus brasiliensis in the small intestine of laboratory rats. Parasitology 55, 313–24.CrossRefGoogle ScholarPubMed
Chandler, A. C., (1936). Studies on the nature of immunity to intestinal helminths. III. Renewal of growth and egg production in Nippostrongylus after transfer from immune to nonimmune rats. American Journal of Hygiene 23, 46–54.Google Scholar
Dash, K. D., (1970). Biology of parasitic nematodes in relation to host immunity. Thesis, University of Queensland Library.Google Scholar
Dineen, J. K., (1963). Immunological aspects of parasitism. Nature, London 197, 471–2.CrossRefGoogle ScholarPubMed
Dineen, J. K., Donald, A. D., Wagland, B. M., & Offner, J., (1965). The dynamics of the host-parasite relationship. III. The response of sheep to primary infection with Haemonchus contortus. Parasitology 55, 515–25.CrossRefGoogle Scholar
Dobson, C., (1964). Host endocrine interactions with nematode infections. I. Effects of sex, gonadectomy, and thyroidectomy on experimental infections in lambs. Experimental Parasitology 15, 200–12.CrossRefGoogle ScholarPubMed
Dobson, C., (1965). The relationship between worm population density, host survival and the growth of the third-stage larva of Amplicaecum robertsi Sprent and Mines, 1960, in the mouse. Parasitology 55, 183–93.CrossRefGoogle ScholarPubMed
Dobson, C., (1966). Distribution of Oesophagostomum columbianum larvae along the alimentary tract of the sheep. Australian Journal of Agricultural Research 17, 756–77.CrossRefGoogle Scholar
Donald, A. D., Dineen, J. K., Turner, J. H., & Wagland, B. M., (1964). The dynamics of the host-parasite relationship. I. Nematodirus spathiger infection in sheep. Parasitology 54, 527–44.CrossRefGoogle ScholarPubMed
Dunsmore, J. D., (1960). Retarded development of Ostertagia species in sheep. Nature, London 186, 986–7.CrossRefGoogle ScholarPubMed
Fordtran, J. S., (1967). Speculations on the pathogenesis of diarrhoea. Federation Proceedings 26, 1405–14.Google Scholar
Fourie, P. J. J., (1936). A contribution to the pathology of oesophagostomiasis in sheep. Onderstepoort Journal of Veterinary Research 7, 277–347.Google Scholar
Haley, A. J., & Parker, J. C., (1961). Effect of population density on adult worm survival in primary Nippostrongylus brasiliensis infections in the rat. Proceedings of the Helminthological Society of Washington 28, 176–80.Google Scholar
Hill, R. P., (1926). The estimation of the number of hookworms harboured, by the use of the dilution egg count method. American Journal of Hygiene 6, 19–41.Google Scholar
Jarrett, E. E. E., Jarrett, W. F. H., & Urquhart, G. M., (1968). Quantitative studies on the kinetics of establishment and expulsion of intestinal nematode populations in susceptible and immune hosts. Nippostrongylus brasiliensis in the rat. Parasitology 58, 625–60.CrossRefGoogle ScholarPubMed
Krupp, J. M., (1961). Effects of crowding and of superinfection on habitat selection and egg production in Ancylostoma caninum. Journal of Parasitology 47, 957–61.CrossRefGoogle ScholarPubMed
McCoy, O. R., (1931). Immunity reactions of the dog against hookworm (Ancylostoma caninum) under conditions of repeated infection. American Journal of Hygiene 14, 268–303.Google Scholar
Michel, J. F., (1955). Studies on host resistance to Dictyocaulus infection. I. The phenomenon of inhibited development. Journal of Comparative Pathology 65, 149–58.CrossRefGoogle ScholarPubMed
Michel, J. F., (1963). The phenomena of host resistance and the course of infection of Ostertagia ostertagi in calves. Parasitology 53, 63–84.CrossRefGoogle Scholar
Michel, J. F., (1968). Immunity to helminths associated with tissues. ‘Immunity to Parasites.’ 6th Symposium of the British Society for Parasitology, pp. 67–89.Google Scholar
Michel, J. F., (1969). Some observations on the worm burdens of calves infected daily with Ostertagia ostertagi. Parasitology 59, 575–95.CrossRefGoogle ScholarPubMed
Michel, J. F., (1970). The regulation of populations of Ostertagia ostertagi in calves. Parasitology 61, 435–47.CrossRefGoogle ScholarPubMed
Michel, J. F., Lancaster, M. B., & Hong, C., (1973). Ostertagia ostertagi: Protective immunity in calves. The development in calves of a protective immunity to infection with Ostertagia ostertagi. Experimental Parasitology 33, 179–86.CrossRefGoogle ScholarPubMed
Michell, A. R., (1967). Physiological principles in the management of alimentary dysfunction. The Veterinary Record 80, 375–80.CrossRefGoogle Scholar
Ogilvie, B. M., & Hocexey, D. J., (1968). Effects of immunity on Nippostrongylus brasiliensis adult worms: reversible and irreversible changes in infectivity, reproduction and morphology. Journal of Parasitology 54, 1073–84.CrossRefGoogle ScholarPubMed
Ogilvie, B. M., & Jones, V. E., (1971). Nippostrongylus Brasiliensis: A review of immunity and the host/parasite relationship in the rat. Experimental Parasitology 29, 138–77.CrossRefGoogle ScholarPubMed
Roberts, F. H. S., & O'Sullivan, P. J., (1950). Methods for egg counts and larval cultures for strongyles infecting the gastro-intestinal tract of cattle. Australian Journal of Agricultural Research 1, 99–102.CrossRefGoogle Scholar
Sarles, M. P., (1929). The length of life and rate of loss of the dog hookworm, Ancylostoma caninum. American Journal of Hygiene 10, 667–82.Google Scholar
Stoll, N. R., (1929). Studies with the strongyloid nematode Haemonchus contortus. I. Acquired resistance of hosts under natural reinfection conditions out-of-doors. American Journal of Hygiene 10, 384–418.Google Scholar