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Researches on the Intestinal Protozoa of Monkeys and Man

VIII. An Experimental Study of Some Simian Strains of “Entamoeba coli”

Published online by Cambridge University Press:  06 April 2009

Clifford Dobell
Clifford Dobell
Affiliation:
National Institute for Medical Research, London, N. W. 3
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(i) Amoebae closely resembling Entamoeba coli (of Man) have been studied in macaques (M. rhesus, M. sinicus, M. nemestrinus) and in a marmoset (Hapale jacchus).

(ii) Pure strains of these amoebae have been isolated and cultivated, and carefully compared with similar pure strains of E. coli from Man (E. coli hominis).

(iii) The complete life-cycles of these various strains—amoebae, cysts, and all stages of precystic and metacystic development—have been studied in vitro.

(iv) The “E. coli” of macaques (E. c. macacorum) was experimentally transmitted to a man, who ingested pure culture-cysts of a strain derived from M. rhesus.

(v) The “E. coli” of the marmoset (E. c. jacchi) was likewise transferred to M. sinicus, and from this host again to M. rhesus and Man.

(vi) The natural infections observed in M. sinicus, M. rhesus, and H. jacchus all died out spontaneously after persisting for various periods (4½ years, 2 years, and 1 year respectively). The experimental infection with E. coli macacorum induced in Man also disappeared spontaneously (after about 6 weeks).

(vii) Attempts to infect kittens experimentally with E. coli jacchi were uniformly unsuccessful.

(viii) All infections with “E. coli” from every source—whether natural or experimental—have proved to be completely innocuous.

(ix) Culture-cysts of various strains of “E. coli” have been found able to live at low temperatures for all times up to about 4½ months (maximum 135 days at 1°–2° C., for a strain from H. jacchus).

(x) The “E. coli” of H. jacchus—and all its experimental derivatives—ingests human red blood-corpuscles in vitro as readily as E. histolytica.

(xi) Several strains of E. coli hominis, isolated directly from naturally infected human beings, have been found to possess the same property.

(xii) Since strains of E. coli thus exist—both in men and in monkeys—which eat human red corpuscles avidly, this faculty can no longer be considered as peculiarly characteristic of E. histolytica; and the importance of this observation, for the diagnosis of amoebic dysentery, is therefore emphasized. The statement that E. histolytica ingests red corpuscles, while E. coli does not, is untrue. It is not possible to distinguish these species by this character alone.

(xiii) As it has been found impossible to distinguish various strains of “E. coli” living in macaques, a marmoset, and men, by any recognizable specific feature—all of them being so closely alike morphologically, physiologically, culturally, and in their ability to inhabit these different hosts—it is concluded that no specific difference actually exists between any of them. The “E. coli” of the Macaques and of the Common Marmoset is probably Entamoeba coli itself—the species which naturally inhabits Man.

Type
Research Article
Information
Parasitology , Volume 28 , Issue 4 , October 1936 , pp. 541 - 593
Copyright
Copyright © Cambridge University Press 1936

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References

REFERENCES

Bishop, A. (1927). The effect of increased and decreased oxygen pressure upon the intestinal protozoa of Macacus rhesus. Parasitology, 19, 401.Google Scholar
Bishop, A. (1929). Experiments on the action of emetine in cultures of Entamoeba coli. Parasitology 10, 481.CrossRefGoogle Scholar
Boeck, W. C. (1921). On the longevity of human intestinal protozoan cysts. Amer. J. Hyg. 10, 527.Google Scholar
Burg, S. L. (1928). Observations on a culture of Entamoeba histolytica. Meded. Dienst Volksgesondh Ned.-Ind. 10, 225.Google Scholar
Brumpt, E. (1909). [Discussion in:] Bull. Soc. Path. Exot. 2, 20.Google Scholar
Brumpt, E. (1926). L'Entamoeba coli peut-elle être pathogéne pour l'homme? Expérimentalement elle pent l'être pour le chat. Bull. Acad. Méd. Paris, 95, 284.Google Scholar
Brumpt, E. (1926 a). Infection expérimentale du chat par l'Entamoeba coli Loesch, 1875 Schaudinn emendavit 1093 [sic] Ann. Parasit. 4, 272.Google Scholar
Cunningham, D. D. (1871). A report on cholera. 7th Ann. Rept. Sanit. Comm. Govt. India (for 1870). Appendix B., p. 139. Calcutta. [Also issued separately.]Google Scholar
Desceiens, R. (1927). Sur les protozoaires intestinaux des singes. Bull. Soc. Path. Exot. 10, 19.Google Scholar
Dobell, C. (1909). Researches on the intestinal protozoa of frogs and toads. Quart. J. Micr. Ser. 10, 201.Google Scholar
Dobell, C. (1917). Reports upon investigations in the United Kingdom of dysentery cases received from the Eastern Mediterranean. I.—Amoebic dysentery, and the protozoological investigation of cases and carriers. Medical Research Committee. Special Report Series No. 4. (London: H.M. Stationery Office.)Google Scholar
Dobell, C. (1919). The Amoebae living in Man: a Zoological Monograph. 8°. London.Google Scholar
Dobell, C. (1927). Further observations and experiments on the cultivation of Entamoeba histolytica from cysts. Parasitology, 19, 288.Google Scholar
Dobell, C. (1928). Researches on the intestinal Protozoa of Monkeys and Man.—I. General introduction, and II. Description of the whole life-history of Entamoeba histolytica in cultures. Parasitology 10, 357.Google Scholar
Dobell, C. with Bishop, A. (1929). Parasitology III. The action of emetine on natural amoebic infec tions in macaques.Google Scholar
Dobell, C. with Bishop, A. (1929) The action of emetine on natural amoebic infec tions in macaques Parasitology 10, 446.CrossRefGoogle Scholar
Dobell, C. (1931). Parasitology IV. An experimental study of the histolytica-like species of Entamoeba living naturally in macaques.Google Scholar
Dobell, C. (1931). Parasitology 10, 1.CrossRefGoogle Scholar
Dobell, C. (1933). Parasitology V. The Endolimax of macaques.Google Scholar
Dobell, C. (1933). Parasitology 10, 436.CrossRefGoogle Scholar
Dobell, C. (1934). Parasitology VI. Experiments with the trichomonads of man and the macaques.Google Scholar
Dobell, C. (1934). Parasitology 10, 531.Google Scholar
Dobell, C. (1935). Parasitology VII. On the Enteromonas of macaques and Embadomonas intestinalis.Google Scholar
Dobell, C. (1935). Parasitology 10, 564.Google Scholar
Dobell, C. & Laidlaw, P. P. (1926). The action of ipecacuanha alkaloids on Entamoeba histolytica and some other entozoic amoebae in culture. Parasitology 10, 206.CrossRefGoogle Scholar
Dobell, C. & Laidlaw, P. P. (1926 a). On the cultivation of Entamoeba histolytica and some other entozoic amoebae. Parasitology 10, 283.Google Scholar
Drbohlav, J. (1925). Culture d'Entamoeba coli Loesch, 1875, emend. Schaudin [sic] 1903. Ann. Parasit. 10, 364.Google Scholar
Faust, E. C. (1931). Investigations in Panama during the summer of 1930. Science, 73, 43.Google Scholar
Hegner, R. (1935). Intestinal protozoa from Panama monkeys. J. Parasit. 10, 60.Google Scholar
Hegner, R. & Chu, H. J. (1930). A comparative study of the intestinal protozoa of wild monkeys and man. Amer. J. Hyg. 10, 62.Google Scholar
Hegner, R., Johnson, C. M., & Stabler, R. M. (1932). Host-parasite relations in experimental amoebiasis in monkeys in Panama. Amer. J. Hyg. 10, 394.Google Scholar
Kessel, J. F. (1924). The experimental transfer of certain intestinal protozoa from man to monkeys. Proc. Soc. Exp. Biol. & Med. 10, 206.Google Scholar
Kessel, J. F.(1928). Intestinal protozoa of monkeys. Univ. California Publ. Zool. 10, 275.Google Scholar
Knowles, R. & Das Gupta, B. M. (1934). Some observations on Balantidium coli and Entamoeba histolytica of macaques. Indian Med. Gaz. 10, 390.Google Scholar
Lynch, K. M. (1924). Ingestion of red blood corpuscles by an intestinal amoeba with eight. nucleated cyst. Amer. J. Trop. Med. 10, 43.CrossRefGoogle Scholar
Mathis, C. (1913). Entamibes des singes. Bull. Soc. Méd.-Chir. Indochine, 4, 388.Google Scholar
Mathis, C. & Mencier, L. (1917). Affinités d'Entamoeba legeri et d'E. coli. Arch. Zool. Exp. 10, [Notes & Rev.] 63.Google Scholar
Matthews, J. R. (1919). A mensurative study of the cysts of Entamoeba coli. Ann. Trop. Med. Parasit. 10, 259.Google Scholar
Matthews, J. R.(1919 a). The course and duration of an infection with Entamoeba coli. Ann. Trop. Med. Parasit. 10, 17.CrossRefGoogle Scholar
Mello, U. (1923). l'amebiasi nei Primati. Ann. Igiene, 33, 533.Google Scholar
Morishita, K. & Tsuchimochi, K. (1926). Experimental observations on the dissemination of disease by cockroaches in Formosa. Contrib. Dept. Hyg., Govt. Res. Inst. Formosa. No. 57. [In Japanese: English summary, pp. 1—5.]Google Scholar
O'Connor, F. W. (1919). Intestinal protozoa found during acute intestinal conditions amongst members of the Egyptian Expeditionary Force, 1916—1917. Parasitology, 11, 239.CrossRefGoogle Scholar
Ogawa, J. (1929). Ueber die Reaktion der Gewebe. IV. Mitteilung: Studien über intra zellulare Wasserstoffionenkonzentration der Entamoeba histolytica und Entamoeba coli. Zbl. Bakt. I (Orig.), 114, 68.Google Scholar
Prowazek, S. V. (1912). Weiterer Beitrag zur Kenntnis der Entamöben. VI. Arch. Protistenk. 10, 241.Google Scholar
Rodhain, J. (1933). Sur une coccidie de l'intestin de l'ouistiti: Hapale jacchus penicillatus (Geoffroy). C.R. Soc. Biol. 114, 1357.Google Scholar
Sangiorgi, G. (1933). Ciontributo alla conoscenza delie dissenterie miste (La “Coliamebo blastocistosi”). Pathologica, 25, 71.Google Scholar
Svensson, R. (1935). Studies on human intestinal protozoa [etc] Acta med. scand. Suppi. LXX.Google Scholar
Tanabe, M. & Kuwabara, N. (1931). Studies on the growth of Entamoeba coli in vitro. Keijo J. Med. 10, 199.Google Scholar
Tanabe, M., Kuwabara, N., & Chiba, E. (1930). On the cultivation of Entamoeba coli in Tanabe and Chiba's medium. Keijo J. Med. 10, 91.Google Scholar
Wenyon, C. M. (1926). Protozoology. A Manual for Medical Men, Veterinarians and Zoologists. 8°. 2 vols. London.Google Scholar
Wenyon, C. M. & O'Connor, F. W. (1917). Human Intestinal Protozoa in the Near East. 8°. London. [First published in J. Roy. Army Med. Corps, 28, Nos. 1—6.]Google Scholar