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Population dynamics of Trichuris suis in trickle-infected pigs

Published online by Cambridge University Press:  16 April 2009

P. NEJSUM ,
S. M. THAMSBORG ,
H. H. PETERSEN ,
H. KRINGEL ,
M. FREDHOLM  and
A. ROEPSTORFF
P. NEJSUM*
Affiliation:
Danish Centre for Experimental Parasitology, Department of Veterinary Disease Biology, Copenhagen University Genetics and Bioinformatics, Department of Animal and Veterinary Basic Sciences, Faculty of Life Sciences, Copenhagen University
S. M. THAMSBORG
Affiliation:
Danish Centre for Experimental Parasitology, Department of Veterinary Disease Biology, Copenhagen University
H. H. PETERSEN
Affiliation:
Danish Centre for Experimental Parasitology, Department of Veterinary Disease Biology, Copenhagen University
H. KRINGEL
Affiliation:
Danish Centre for Experimental Parasitology, Department of Veterinary Disease Biology, Copenhagen University
M. FREDHOLM
Affiliation:
Genetics and Bioinformatics, Department of Animal and Veterinary Basic Sciences, Faculty of Life Sciences, Copenhagen University
A. ROEPSTORFF
Affiliation:
Danish Centre for Experimental Parasitology, Department of Veterinary Disease Biology, Copenhagen University
*
*Corresponding author: Danish Centre for Experimental Parasitology, Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Dyrlaegevej 100, DK-1870, Frederiksberg C, Copenhagen, Denmark. Tel: +45 35283783. Fax: +45 35282774. E-mail: pn@life.ku.dk
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Summary

The population dynamics of Trichuris suis in pigs was studied during long-term experimental infections. Twenty-three 10-week-old pigs were inoculated with 5 T. suis eggs/kg/day. Seven, 8, and 8 pigs were necropsied at weeks 4, 8, and 14 post-start of infection (p.i.), respectively. The median numbers of worms in the colon were 538 (min–max: 277–618), 332 (14–1140) and 0 (0–4) at 4, 8, and 14 weeks p.i. respectively, suggesting an increased aggregation of the worms with time and acquisition of nearly sterile immunity. The serum levels of T. suis specific antibodies (IgG1, IgG2 and IgA) peaked at week 8 p.i. By week 14 p.i. the IgG2 and IgA antibody levels remained significantly elevated above the level of week 0. The population dynamics of T. suis trickle infections in pigs is discussed with focus on interpretation of diagnostic and epidemiological data of pigs, the use of pigs as a model for human Trichuris trichiura infections and the novel approach of using T. suis eggs in the treatment of patients with inflammatory bowel disease.

Keywords

Trichuris suispigpopulation dynamicstrickle infectionaggregationELISA
Type
Research Article
Information
Parasitology , Volume 136 , Issue 6 , May 2009 , pp. 691 - 697
Copyright
Copyright © Cambridge University Press 2009

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