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Nippostrongylus brasiliensis: observations on the comparative immunogenicity of adult worms from primary and immune-adapted infections

Published online by Cambridge University Press:  06 April 2009

D. Conwil Jenkins
D. Conwil Jenkins
Affiliation:
The Research Laboratories, May and Baker Ltd., Dagenham, Essex
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Extract

A comparison was made of the immunogenicity of normal worms, derived from a primary infection, and immune-adapted worms, derived from a trickle infection, after surgical transfer into previously uninfected rats. Exposure to 300 normal worms for 2 days was sufficient to induce resistance to challenge infection 3 weeks later in four of eight rats. The immune-adapted worms were, however, significantly less immunogenic, only one rat in ten developing resistance to challenge after 21 days exposure to 300 worms. These results offer further evidence that the protective antigens produced by normal worms are in some way altered in adapted worms, so that adapted worms have a reduced immunogenicity.

Type
Research Article
Information
Parasitology , Volume 65 , Issue 3 , December 1972 , pp. 547 - 550
Copyright
Copyright © Cambridge University Press 1972

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