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Morphological effects of arprinocid on developmental stages of Eimeria tenella and E. brunetti

Published online by Cambridge University Press:  06 April 2009

S. J. Ball ,
R. M. Pittilo ,
C. C. Norton  and
L. P. Joyner
S. J. Ball
Affiliation:
Department of Biology and Biochemistry, North East London Polytechnic, Romford Road, London E15 4LZ
R. M. Pittilo
Affiliation:
E. M. Unit, Histopathology Department, The Bland Sutton Institute of Pathology, The Middlesex Hospital Medical School, London W1 P 7PN
C. C. Norton
Affiliation:
Central Veterinary Laboratory, MAFF, New Haw, Weybridge, Surrey KT15 3NB
L. P. Joyner
Affiliation:
Central Veterinary Laboratory, MAFF, New Haw, Weybridge, Surrey KT15 3NB
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Extract

Medication of chicks with 70p.p.m. arprinoeid in the food, starting 2 days prior to inoculation with Eimeria tenella, resulted in decreased oocyst production and oocyst sporulation. The main morphological alteration seen during the development of the second-generation schizont was a reduction in the number of second-generation merozoites due to incomplete merogony, resulting in large masses of vacuolated residual cytoplasm. In places around the developing macrogamete the integrity of the parasitophorous vacuole was lost by either the host cell limiting membrane making contact with the parasite pellicle, or the disruption of one or both of these surfaces apparently brought about by the intervention of the host cell mitochondria. Thirty p.p.m. arprinocid reduced sporulation of the oocysts of E. brunetti and caused enlargement of the perinuclear space in the late merozoites and swelling of the endoplasmic reticulum around wall-forming bodies II.

Type
Research Article
Information
Parasitology , Volume 91 , Issue 1 , August 1985 , pp. 31 - 43
Copyright
Copyright © Cambridge University Press 1985

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