Skip to main content Accessibility help
×
Home

Interactions between infections with Eimeria spp. and Trichinella spiralis in inbred mice

  • M. E. Roses (a1), D. Wakelin (a2) and P. Hesketh (a1)

Summary

Parasitological and immunological interactions between Eimeria vermiformis or E. pragensis and Trichinella spiralis were investigated during concurrent infections in NIH, BALB/c and B10.G inbred mice. The establishment of T. spiralis was unaffected by the presence of either coccidium, but expulsion of adult worms was delayed significantly in mice infected with E. vermiformis; E. pragensis did not have this effect. Replication of E. vermiformis was enhanced in concurrent infections with T. spiralis, but that of E. pragensis was reduced. Specific immune responses to each parasite were unaffected in mice infected with T. spiralis and E. pragensis, but levels of some responses were reduced when T. spiralis and E. vermiformis were combined. Thus both in vitro antigen-induced proliferation of mesenteric lymph node cells (MLNC) and intestinal mastocytosis were lower than in singly infected mice. Mitogen (Con A) responsiveness of MLNC was not affected in mice infected with T. spiralis and E. vermiformis, and cells from these mice were capable of transferring protective immunity to the nematode in naive recipients. Injection of monoclonal antibody to interferon gamma, a major component of the cytokine response to E. vermiformis, did not prevent delay of worm expulsion in concurrent infections. The results are discussed in terms of possible interactions between the T helper cell subsets or the inflammatory components of the responses induced by each parasite.

Copyright

References

Hide All
Bristol, J. R., Pinon, A. J. & Mayberry, L. F. (1983). Interspecific interactions between Nippostrongylus brasiliensis and Eimeria nieschulzi in the rat. Journal of Parasitology 69, 372–4.
Broaddus, R. R., Mayberry, L. F., Bristol, J. R. & Upton, S. J. (1987). Suppression of Nippostrongylus brasiliensis (Nematode)-induced lysophospholipase activity and peripheral eosinophilia by Eimeria nieschulzi (Apicomplexa). Journal of Parasitology 73, 739–42.
Castro, G. A. & Duszynski, D. W. (1984). Local and systemic effects on inflammation during Eimeria nieschulzi infection. Journal of Protozoology 31, 283–7.
Catchpole, J. & Harris, T. J. (1989). Interaction between coccidia and Nematodirus battus in lambs on pasture. Veterinary Record 124, 603–5.
Duszynski, D. W., Russell, D., Roy, S. A. & Castro, G. (1978 a). Suppressed rejection of Trichinella spiralis in immunized rats concurrently infected with Eimeria nieschulzi. Journal of Parasitology 64, 83–8.
Duszynski, D. W., Roy, S. A. & Castro, G. A. (1978 b). Intestinal disaccharidase and peroxidase deficiencies during Eimeria nieschulzi infections in rats. Journal of Protozoology 25, 226–31.
Grencis, R. K., Riedlinger, J. & Wakelin, D. (1985). L3T4-positive T lymphoblasts are responsible for transfer of immunity to Trichinella spiralis in mice. Immunology 56, 213–18.
Grencis, R. K., Hültner, L. & Else, K. J. (1991). Host protective immunity to Trichinella spiralis in mice: activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes. Immunology 74, 329–32.
Lee, T. D. G., Grencis, R. K. & Wakelin, D. (1982). Specific cross-immunity between Trichinella spiralis and Trichuris muris: immunization with heterologous infections and antigens, and transfer of immunity with heterologous immune mesenteric lymph node cells. Parasitology 84, 381–9.
Mayberry, L. F., Bristol, J. R. & Villalobos, V. M. (1985). Intergeneric interactions between Eimeria separata (Apicomplexa) and Nippostrongylus brasiliensis (Nematoda) in the rat. Experientia 41, 689–90.
Rose, M. E. & Hesketh, P. (1982). Coccidiosis: T-lymphocyte dependent effects of infection with Eimeria nieschulzi in rats. Veterinary Immunology and Immunopathology 3, 499508.
Rose, M. E. & Hesketh, P. (1986). Eimerian life cycles: the patency of Eimeria vermiformis but not E. pragensis is subject to host (Mus musculus) influence. Journal of Parasitology 72, 949–54.
Rose, M. E. & Mockett, A. P. A. (1983). Antibodies to coccidia: detection by the enzyme-linked immunosorbent assay (ELISA). Parasite Immunology 5, 479–89.
Rose, M. E., Wakelin, D. & Hesketh, P. (1990). Eimeria vermiformis: differences in the course of primary infection can be correlated with lymphocyte responsiveness in the BALB/c and C57BL/6 mouse, Mus musculus. Experimental Parasitology 71, 276–83.
Rose, M. E., Wakelin, D. & Hesketh, P. (1991). Interferon-gamma-mediated effects upon immunity to coccidial infections in the mouse. Parasite Immunology 13, 6374.
Stewart, G. L., Reddington, J. J. & Hamilton, A. M. (1980). Eimeria nieschulzi and Trichinella spiralis: analysis of concurrent infection in the rat. Experimental Parasitology 50, 115–22.
Terry, R. J. & Hudson, K. M. (1982). Immunodepression in parasitic infections. Fortschritte der Zoologie 27, 125–39.
Upton, S. J., Mayberry, L. P., Bristol, J. R., Favela, S. H. & Sambrano, G. R. (1987). Suppression of peripheral eosinophilia by the coccidium Eimeria nieschulzi (Apicomplexa: Eimeriidae) in experimentally infected rats. Journal of Parasitology 73, 300–8.
Wakelin, D. & Grencis, R. K. (1992). T Cell and genetic control of inflammatory cells. In Allergy and Immunity to Helminths (ed. Moqbel, R.), pp. 108–36. London: Taylor & Francis.
Wakelin, D. & Lloyd, M. (1976). Immunity to primary and challenge infections of Trichinella spiralis in mice: a re-examination of conventional parameters. Parasitology 72, 173–82.
Wakelin, D. & Rose, M. E. (1990). Immunity to coccidiosis. In Coccidiosis of Man and Domestic Animals (ed. Long, P. L.), pp. 281306. Boca Raton, Florida: CRC Press.
Wakelin, D., Rose, M. E., Hesketh, P., Else, K. J. & Grencis, R. K. (1993). Immunity to coccidiosis: genetic influences on lymphocyte and cytokine responses to infection with Eimeria vermiformis in inbred mice. Parasite Immunology 15, 1119.

Keywords

Related content

Powered by UNSILO

Interactions between infections with Eimeria spp. and Trichinella spiralis in inbred mice

  • M. E. Roses (a1), D. Wakelin (a2) and P. Hesketh (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.