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Insights on adaptive and innate immunity in canine leishmaniosis

  • SHAZIA HOSEIN (a1), DAMER P. BLAKE (a1) and LAIA SOLANO-GALLEGO (a2)

Summary

Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities. Clinical manifestations can range from subclinical infection to very severe systemic disease. Leishmaniosis is categorized as a neglected tropical disease and the complex immune responses associated with Leishmania species makes therapeutic treatments and vaccine development challenging for both dogs and humans. In this review, we summarize innate and adaptive immune responses associated with L. infantum infection in dogs, and we discuss the problems associated with the disease as well as potential solutions and the future direction of required research to help control the parasite.

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Copyright

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

*Corresponding authors. Department of Pathology and Pathogen Biology, Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, AL9 7TA, UK and Department de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Valles, Barcelona, Spain. E-mail: shaziahosein@gmail.com; laia.solano@uab.cat

References

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