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The influence of the H-2 complex on responses to infection by Schistosoma mansoni in mice

Published online by Cambridge University Press:  06 April 2009

Janet T. Jones ,
D. M. Mccaffery  and
J. R. Kusel
Janet T. Jones
Affiliation:
Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ
D. M. Mccaffery
Affiliation:
Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ
J. R. Kusel
Affiliation:
Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ
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Summary

In order to determine whether a given H-2 haplotype has similar effects on responses to schistosomiasis mansoni on different genetic backgrounds, mice of 2 pairs of congenic strains (H-2b and H-2k on BALB/c and C57BL/10 backgrounds) were infected. Worm burdens, mortality, splenomegaly, tissue and faecal egg counts, and antibody titres to worm and egg antigens were measured. The genetic background had a major effect on the genesis of splenomegaly, on the deposition of eggs in the spleen, the maximum faecal egg count, the antibody titre to egg and worm antigens and the rate of generation of antibody response. The H-2 haplotype was shown to consistently influence the maximum faecal egg count and the antibody titres. Worm burden was not influenced by genetic differences between strains and mortality differences were not significant. The data presented here indicate that the effect of the major histocompatibility complex on responses to infection is greatly influenced by the genetic background on which it is expressed.

Type
Research Article
Information
Parasitology , Volume 86 , Issue 1 , February 1983 , pp. 19 - 30
Copyright
Copyright © Cambridge University Press 1983

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