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Induction and regulation of Trypanosoma brucei VSG-specific antibody responses

Published online by Cambridge University Press:  22 December 2009

S. J. BLACK ,
P. GUIRNALDA ,
D. FRENKEL ,
C. HAYNES  and
V. BOCKSTAL
S. J. BLACK*
Affiliation:
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts, USA
P. GUIRNALDA
Affiliation:
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts, USA
D. FRENKEL
Affiliation:
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts, USA
C. HAYNES
Affiliation:
Laboratory for Cellular and Molecular Immunology, Vrije Universiteit Brussel, Pleinlaan 2, B-1050Brussels, Belgium Department of Molecular and Cellular Interactions, VIB, Brussels, Belgium
V. BOCKSTAL
Affiliation:
Laboratory for Cellular and Molecular Immunology, Vrije Universiteit Brussel, Pleinlaan 2, B-1050Brussels, Belgium Department of Molecular and Cellular Interactions, VIB, Brussels, Belgium
*
*Corresponding author: Department of Veterinary and Animal Sciences, University of Massachusetts-Amherst, MA, 01003, USA. Tel: 413 545 2573. Fax: 413 545 6326. E-mail: sblack@vasci.umass.edu
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Summary

The review addresses how infection with Trypanosoma brucei affects the development, survival and functions of B lymphocytes in mice. It discusses (1) the contributions of antibodies to trypanosome clearance from the bloodstream, (2) how B lymphocytes, the precursors of antibody producing plasma cells, interact with membrane form variable surface glycoprotein (VSG), i.e. with monovalent antigen that is free to diffuse within the lipid bilayer of the trypanosome plasma membrane and consequently can cross-link B cell antigen specific receptors by indirect processes only and (3) the extent and underlying causes of dysregulation of humoral immune responses in infected mice, focusing on the impact of wild type and GPI-PLC−/− trypanosomes on bone marrow and extramedullary B lymphopoiesis, B cell maturation and survival.

Keywords

T. bruceiantibody clearanceB cell activationB cell deletion
Type
Research Article
Information
Parasitology , Volume 137 , Special Issue 14: African trypanosomiasis: New insights for disease control , December 2010 , pp. 2041 - 2049
Copyright
Copyright © Cambridge University Press 2009

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