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In vivo regulation of S. japonica granuloma formation by an IL-2 antagonist

Published online by Cambridge University Press:  06 April 2009

T. F. Kresina
T. F. Kresina
Affiliation:
Department of Medicine, Program of Geographic Medicine, Miriam Hospital and Brown University International Health Institute, Providence, Rhode Island 02906, USA
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Summary

The present study shows an in vivo role for interleukin-2 in the formation of hepatic granulomatous inflammation in murine Schistosoma japonicum infection. Mice which had been administered an inhibitor to interleukin-2 function during acute infection were noted to have reduced cell-mediated immune responses to ConA and S. japonicum soluble egg antigen (SEA). Lymphoid tissue from these treated mice also have reduced numbers of cells which could be activated by ConA to produce interleukin-2 mRNA as shown by in situ hybridization studies. Mice with less activated lymphocytes had, on the average, a 70% reduction in the granulomatous inflammation surrounding eggs deposited in hepatic tissues of acutely infected mice. The data demonstrate that IL-2 is a key factor in the generation of granulomatous inflammation in S. japonicum infection and suggest that a potential anti-pathology vaccine could be generated based on limiting the presence of IL-2 generated during acute infection.

Keywords

granulomainflammationIL-2contra-IL-2T cells
Type
Research Article
Information
Parasitology , Volume 102 , Issue 2 , April 1991 , pp. 243 - 249
Copyright
Copyright © Cambridge University Press 1991

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