Hostname: page-component-848d4c4894-nmvwc Total loading time: 0 Render date: 2024-06-27T11:53:05.616Z Has data issue: false hasContentIssue false
  • English
  • Français

Immunodepression in Giardia muris and Spironucleus muris infections in mice

Published online by Cambridge University Press:  06 April 2009

Sara J. Brett
Sara J. Brett
Affiliation:
Department of Zoology, King's College, The Strand, London WC2R 2LS
Get access Rights & Permissions [Opens in a new window]

Summary

Infections with the intestinal flagellates Giardia muris and Spironucleus muris are accompanied by a depression in the ability of mice to mount an immune response to a thymus-dependent antigen (sheep red blood cells) but not to a thymus-independent antigen (TNP-lipopolysaccharide). The number of splenic IgM plaque-forming cells and haemagglutination titres, of both IgM and IgG, to sheep red blood cells decreased between days 10 and 21, which correlated with the time of maximal trophozoite levels in the small intestine. The number of background IgM plaque-forming cells to sheep red blood cells or DNP was not significantly different from controls in either infection. No evidence for systemic macrophage activation was associated with these infections. In fact, adherent peritoneal exudate cells (PEC) from infected mice were slightly less cytostatic against target tumour cells than adherent PEC from normal mice, at a time when the parasites were being eliminated from the small intestine.

Type
Research Article
Information
Parasitology , Volume 87 , Issue 3 , December 1983 , pp. 507 - 515
Copyright
Copyright © Cambridge University Press 1983

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Aaronson, S. A. & Weaver, C. A. (1971). Characterisation of murine sarcoma virus (KIRSTEN). Transformation of murine and human cells. Journal of General Virology 13, 245–52.CrossRefGoogle ScholarPubMed
Boyle, M. D. & Ormerod, M. G. (1976). Destruction of allogeneic tumour cells by peritoneal macrophages. Production of lytic effectors by immune mice. Transplantation 21, 242–6.CrossRefGoogle Scholar
Brett, S. J. & Cox, F. E. G. (1982). Immunological aspects of Giardia muris and Spironucleus muris infections in inbred and outbred strains of laboratory mice: a comparative study. Parasitology 85, 85–99.CrossRefGoogle ScholarPubMed
Calderon, J., Williams, R. T. & Unanue, E. R. (1974). An inhibitor of cell proliferation released by cultures of macrophages. Proceedings of the National Academy of Sciences, USA 71, 4273–7.CrossRefGoogle ScholarPubMed
Cunningham, A. J. & Szenberg, A. (1968). Further improvements in the plaque technique for detecting single antibody forming cells. Immunology 14, 599–600.Google ScholarPubMed
Goldman, R. & Hogg, N. (1978). Enhanced susceptibility of virus infected fibroblasts to cytostasis mediated by peritoneal exudate cells. Journal of Immunology 121, 1657–63.CrossRefGoogle ScholarPubMed
Hudson, L. & Hay, F. C. (1976). In Practical Immunology, p. 125. Oxford: Blackwell Scientific Publications.Google Scholar
Jacobs, D. M. & Morrison, D. C. (1975). Stimulation of a T-independent primary anti-hapten response in vitro by TNP-lipopolysaccharide. Journal of Immunology 114, 360–4.CrossRefGoogle ScholarPubMed
Keast, D. & Chesterman, F. C. (1972). Changes in macrophage metabolism in mice heavily infected with Hexamita muris. Laboratory Animals 6, 33–9.CrossRefGoogle ScholarPubMed
Loose, L. D., Cook, J. A. & Di Luzio, N. R. (1972). Malarial immuno-depression: a macrophage mediated defect. Proceedings of the Helminthological Society of Washington 39, (Special issue) 484–91.Google Scholar
Meltzer, M. S. (1976). Tumoricidal responses in vitro of peritoneal macrophages from conventionally housed and germ free nude mice. Cellular Immunology 22, 176–81.CrossRefGoogle ScholarPubMed
Miller, J. F. A. & Mitchell, G. F. (1968). Cell to cell interaction in the immune response. 1. Haemolysin-forming cells in neonatally thymectomized mice reconstituted with thymus or thoracic duct lymphocytes. Journal of Experimental Medicine 128, 801–20.CrossRefGoogle ScholarPubMed
Mishell, R. I. & Dutton, R. W. (1967). Immunisation of dissociated spleen cell cultures from normal mice. Journal of Experimental Medicine 126, 423–42.CrossRefGoogle ScholarPubMed
Mosier, D. E. (1967). Requirement for 2 cell types for antibody formation in vitro. Science 158, 1573–5.CrossRefGoogle Scholar
Ogilvie, B. M. & Parrott, D. M. V. (1977). The immunological consequences of nematode infections. In Immunology of the Gut (ed. Porter, R. and Knight, J.), pp. 183–194. Ciba Foundation Symposium 46, Elsevier Excerpta Medica, North Holland.Google Scholar
Roberts-Thomson, I. C., Stevens, D. P., Mahmoud, A. A. F. & Warren, K. S. (1976). Giardiasis in the mouse: an animal model. Gastroenterology 71, 57–61.CrossRefGoogle ScholarPubMed
Rose, M. E., Hesketh, P. & Ogilvie, B. M. (1980). Coccidiosis: localisation of lymphoblasts in the infected small intestine. Parasite Immunology 2, 189–99.CrossRefGoogle ScholarPubMed
Rose, M. L., Parrott, D. M. V. & Bruce, R. G. (1976). Migration of lymphocytes to the small intestine. 1. The effect of Trichinella spiralis infection on the migration of mesenteric lymphocytes in syngeneic mice. Immunology 31, 723–30.Google Scholar
Ruitenberg, E. J. & Kruyt, B. C. (1975). The effect of intestinal flagellates on the immune response of mice. Parasitology 71, xxx.Google Scholar
Smith, P. D., Elson, C. O., Keister, D. B. & Nash, T. E. (1982). Human host response to Giardia lamblia. 1. Spontaneous killing by mononuclear leukocytes in vitro. Journal of Immunology 128, 1372–6.CrossRefGoogle ScholarPubMed
Sparrow, S. (1976). The microbiological and parasitological status of laboratory animals from accredited breeders in the UK. Laboratory Animals 10, 365–73.CrossRefGoogle Scholar
Terry, R. & Hudson, K. (1982). Immunodepression in parasitic infections. Fortschritte der Zoologie 27, 125–39.Google Scholar