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Immune responses during the acute stages of infection with the intestinal trematode Echinostoma caproni

  • L. R. BRUNET (a1), S. JOSEPH (a1), D. W. DUNNE (a1) and B. FRIED (a2)

Abstract

This study investigated the nature of the immune response of C57BL/6 mice infected with the trematode Echinostoma caproni. To determine the preferential development of either a Th1 or Th2 cytokine pattern during early stages of infection, cytokine production by spleen and mesenteric lymph node (MLN) cells during the first 3 weeks of infection was followed. Whereas spleen cells failed to respond to antigen stimulation, MLN cells produced IFN-γ and to a lesser extent IL-4. IL-5 levels were elevated throughout the period studied. The humoral response was consistent with a Th1 cytokine pattern as antigen-specific IgG2a antibodies were preferentially developed. We investigated whether IFN-γ is critical for establishment of E. caproni infection. Worm burden in infected mice treated with a single injection of anti-IFN-γ mAb was significantly reduced compared to that of animals treated with a control antibody.

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Corresponding author

Corresponding author: Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK. Tel: +44 1223 333332. Fax: +44 1223 333741. E-mail: lrb22@mole.bio.cam.ac.uk

Keywords

Immune responses during the acute stages of infection with the intestinal trematode Echinostoma caproni

  • L. R. BRUNET (a1), S. JOSEPH (a1), D. W. DUNNE (a1) and B. FRIED (a2)

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