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Immune expulsion of Trichuris muris from resistant mice: suppression by irradiation and restoration by transfer of lymphoid cells

  • D. Wakelin (a1) and Gwendoline R. Selby (a1)


Lethal irradiation (850 rads) of mice made resistant to Trichuris muris markedly depressed their ability to expel a challenge infection. Expulsion was restored within 7–10 days when MLNC from uninfected mice were transferred on the day of infection, but no significant restoration was evident after transfer of immune serum. Transfer of BM alone had no restorative effect within 10 days and no synergism was seen when both BM and MLNC were transferred. MLNC from uninfected donors did not restore challenge expulsion when transfer was delayed until day 7 and the mice were killed 3 days later, although MLNC from resistant donors were effective within this time. When irradiated mice were given BM and the challenge infection allowed to continue for 15 days expulsion was restored, as it was when challenge was delayed for 7 days after BM transfer in thymectomized mice. The results confirm that expulsion of T. muris involves both antibody-mediated and lymphoid cell-mediated phases and offer no evidence for the involvement of other cell types.



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Dineen, J. K. & Kelly, J. D. (1973). Expulsion of Nippostrongylus brasiliensis from the intestine of rats: the role of a cellular component derived from bone marrow. International Archives of Allergy and Applied Immunology 45, 759–66.
Friedberg, W., Cearley, J. E., Neas, B. R., Faulkner, D. N. & Coleman, R. L. (1970). Persistence of pre-irradiation immunity to Hymenolepis nana in syngeneic chimaeras: influence of radiation dose and time of marrow injection. International Journal of Radiation Biology 17, 449–58.
Harris, G. & Šljivič, V. (1972). The acute effects of ionizing radiation on antibody-producing cells (PFC) in mouse spleen during primary and secondary responses to sheep erythrocytes (SRC). Immunology 23, 147–58.
Larsh, J. E. & Weatherly, N. F. (1975). Cell-mediated immunity against certain parasitic worms. Advances in Parasitology 13, 183222.
Makinodan, T., Nettesheim, P., Morita, T. & Chadwick, C. J. (1967). Synthesis of antibody by spleen cells after exposure to kiloroentgen doses of ionizing radiation. Journal of Cellular Physiology 69, 355–66.
Miller, J. F. A. P. & Mitchell, G. F. (1969). Thymus and antigen reactive cells. Transplantation Reviews 1, 343.
Nossal, G. J. V. & Pike, B. L. (1973). Studies on the differentiation of B lymphocytes in the mouse. Immunology 25, 3345.
Pilarski, L. M. & Cunningham, A. J. (1975). Host-derived antibody-forming cells in lethally irradiated mice. Journal of Immunology 114, 138–40.
Playfair, J. H. L. & Marshall-Clarke, S. (1973). Crossreactions between erythrocytes at the T-cell level. Immunology 24, 579–88.
Selby, G. R. & Wakelin, D.(1973). Transfer of immunity against Trichuris muris in the mouse by serum and cells. International Journal for Parasitology 3, 717–22.
Selby, G. R. & Wakelin, D.(1975). Suppression of the immune response to Trichuris muris in lactating mice. Parasitology 71, 7785.
Taliaferro, W. H., Taliaferro, L. G. & Jaroslow, B. M. (1964). Radiation and Immune Response. New York, London: Academic Press.
Trowell, O. A. (1952). The sensitivity of lymphocytes to ionizing radiation. Journal of Pathology and Bacteriology 64, 687704.
Visakorpi, R. (1972). Effect of irradiation on established delayed hypersensitivity. Acta pathologica et microbiologica scandinavica, Section B 80, 788–94.
Volkman, A. & Collins, F. M. (1968). Recovery of delayed-type hypersensitivity in mice following suppressive doses of X-radiation. Journal of Immunology 101, 846–59.
Wakelin, D. (1967). Acquired immunity to Trichuris muris in the albino laboratory mouse. Parasitology 57, 515–24.
Wakelin, D. (1970). The stimulation of immunity and the induction of unresponsiveness to Trichuris muris in various strains of laboratory mice. Zeitschrift füur Parasitologic 35, 162–8.
Wakelin, D. (1973). The stimulation of immunity to Trichuris muris in mice exposed to low-level infections. Parasitology 66, 181–9.
Wakelin, D. (1975). Immune expulsion of Trichuris muris from mice during a primary infection: analysis of the components involved. Parasitology 70, 397405.
Wakelin, D. & Selby, G. R. (1974). Thymus dependency of the immune response of mice to a primary infection with the nematode Trichuris muris. International Journal for Parasitology 4, 657–61.
Youdin, S., Stutman, O. & Good, R. A. (1973). Studies of delayed hypersensitivity to L. monocytogenes in mice: nature of cells involved in passive transfers. Cellular Immunology 6, 98109.

Immune expulsion of Trichuris muris from resistant mice: suppression by irradiation and restoration by transfer of lymphoid cells

  • D. Wakelin (a1) and Gwendoline R. Selby (a1)


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