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Immune control of murine coccidiosis: CD4+ and CD8+ T lymphocytes contribute differentially in resistance to primary and secondary infections

Published online by Cambridge University Press:  06 April 2009

M. E. Rose ,
P. Hesketh  and
D. Wakelin
M. E. Rose
Affiliation:
Houghton Laboratory, AFRC Institute for Animal Health, Houghton, Huntingdon, Cambs PE17 2DA
P. Hesketh
Affiliation:
Houghton Laboratory, AFRC Institute for Animal Health, Houghton, Huntingdon, Cambs PE17 2DA
D. Wakelin
Affiliation:
Department of Life Science, School of Biological Sciences, University of Nottingham, University Park, Nottingham NG7 2RD
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Summary

The effect of treatment with monoclonal antibodies (Mabs) which deplete CD4+ or CD8+ T lymphocytes, on infections with Eimeria spp. was examined in NIH mice. Treatment with anti-CD4 Mab increased susceptibility to primary infections with E. vermiformis or E. pragensis and reduced the subsequent resistance of the mice to homologous challenge. Similar treatment of immune mice did not affect their resistance to re-infection but this was reduced in mice depleted of CD8+ T lymphocytes. In mice immunized with E. vermiformis the effect of CD8+-depletion was very slight, apparent only as the presence of small numbers of oocysts in the faeces of some mice; in mice immunized with E. pragensis there was a small, though significant, increase in oocyst production, compared with controls and anti-CD4-treated groups. These results confirm the importance of mechanisms involving the function of CD4+ T lymphocytes in the control of primary infections with Eimeria spp. and indicate that CD8+ cells play some part in the expression of resistance to reinfection. They also show that a major part of this resistance was not affected by either of the treatments given.

Keywords

Eimeria pragensis, Eimeria vermiformis, coccidiosis, immunity, CD4+ T lymphocytes, CD8+ T lymphocytes.
Type
Research Article
Information
Parasitology , Volume 105 , Issue 3 , December 1992 , pp. 349 - 354
Copyright
Copyright © Cambridge University Press 1992

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References

REFERENCES

Al-Attar, M. A. & Fernando, M. A. (1987). Transport of Eimeria necatrix sporozoites in the chicken: effects of irritants injected intraperitoneally. Journal of Parasitology 73, 494–502.CrossRefGoogle ScholarPubMed
Bucy, R. P., Chen, C.-L. H., Cihak, J., Lösch, V. & Cooper, M. D. (1988). Avian T cells expressing γδ receptors localize in the splenic sinusoids and the intestinal epithelium. Journal of Immunology 141, 2200–5.CrossRefGoogle Scholar
Davis, P. J. (1981). Immunity to coccidia. In Avian Immunology. British Poultry Science Symposium No. 16, (ed. Rose, M. E., Payne, L. N. & Freeman, B. M.), pp. 361–85. Edinburgh, UK: British Poultry Science Ltd.Google Scholar
Guy-Grand, D., Cerf-Bensussan, N., Malissen, B., Malassis-Seris, M., Briottet, C. & Vassalli, P. (1991). Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. Journal of Experimental Medicine 173, 471–81.CrossRefGoogle ScholarPubMed
Hiromatsu, K., Yoshikai, Y., Matsuzaki, G., Ohga, S., Muramori, K., Matsumoto, K., Bluestone, J. A. & Nomoto, K. (1992). A protective role of γ/δ T cells in primary infection with Listeria monocytogenes in mice. Journal of Experimental Medicine 175, 49–56.CrossRefGoogle ScholarPubMed
Janis, E. M., Kaufman, S. H. E., Schwartz, R. H. & Pardoll, D. M. (1989). Activation of γδ T cells in the primary immune response to Mycobacterium tuberculosis. Science 244, 713–16.CrossRefGoogle Scholar
Lawn, A. M. & Rose, M. E. (1982). Mucosal transport of Eimeria tenella in the cecum of the chicken. Journal of Parasitology 68, 1117–23.CrossRefGoogle ScholarPubMed
Podoba, J. E. & Stevenson, M. M. (1991). CD4+ and CD8+ T lymphocytes both contribute to acquired immunity to blood-stage Plasmodium chabaudi AS. Infection and Immunity 59, 51–8.CrossRefGoogle ScholarPubMed
Riley, D. & Fernando, M. A. (1988). Eimeria maxima (Apicomplexa): a comparison of sporozoite transport in naive and immune chickens. Journal of Parasitology 74, 103–10.CrossRefGoogle ScholarPubMed
Rose, M. E. & Hesketh, P. (1986). Eimerian life cycles: the patency of Eimeria vermiformis but not E. pragensis is subject to host (Mus musculus) influence. Journal of Parasitology 72, 949–54.CrossRefGoogle Scholar
Rose, M. E., Joysey, H. S., Hesketh, P., Grencis, R. K. & Wakelin, D. (1988). Mediation of immunity to Eimeria vermiformis in mice by L3T4+ T cells. Infection and Immunity 56, 1760–5.CrossRefGoogle ScholarPubMed
Rose, M. E., Lawn, A. M. & Millard, B. J. (1984 a). The effect of immunity on the early events in the life-cycle of Eimeria tenella in the caecal mucosa of the chicken. Parasitology 88, 199–210.CrossRefGoogle ScholarPubMed
Rose, M. E., Owen, D. G. & Hesketh, P. (1984 b). Susceptibility to coccidiosis: effect of strain of mouse on reproduction of Eimeria vermiformis. Parasitology 88, 45–54.CrossRefGoogle ScholarPubMed
Rose, M. E., Wakelin, D. & Hesketh, P. (1985). Susceptibility to coccidiosis: contrasting course of primary infection with Eimeria vermiformis in BALB/c and C57BL/6 mice is based on immune responses. Parasite Immunology 7, 557–66.CrossRefGoogle ScholarPubMed
Rose, M. E., Wakelin, D. & Hesketh, P. (1989). Gamma interferon controls Eimeria vermiformis primary infections in BALB/c mice. Infection and Immunity 57, 1599–603.CrossRefGoogle ScholarPubMed
Rose, M. E., Wakelin, D. & Hesketh, P. (1991). Interferon-gamma-mediated effects upon immunity to coccidial infections in the mouse. Parasite Immunology 13, 63–74.CrossRefGoogle ScholarPubMed
Shi, Y., Mahrt, J. L. & Mogil, R. J. (1988). Kinetics of murine delayed-type hypersensitivity response to Eimeria falciformis (Apicomplexa: Eimeriidae). Infection and Immunity 57, 146–51.CrossRefGoogle Scholar
Suzuki, Y. & Remington, J. S. (1988). Dual regulation of resistance against Toxoplasma gondii infection by Lyt-2+ and Lyt-1+, L3T4+ T cells in mice. Journal of Immunology 140, 3943–6.CrossRefGoogle ScholarPubMed
Wakelin, D. & Rose, M. E. (1990). Immunity to coccidiosis. In Coccidiosis of Man and Domestic Animals (ed. Long, P. L.), pp. 281–306. CRC Press Inc., Boca Raton, USA.Google Scholar