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Host-parasite relationship between congenital Toxoplasma infection and mouse brain: role of small vessels

Published online by Cambridge University Press:  06 April 2009

T. A. Sims  and
J. Hay
T. A. Sims
Affiliation:
University Department of Pathology, Leicester Royal Infirmary, Leicester LE2 7LX
J. Hay
Affiliation:
Tennent Institute of Ophthalmology, University of Glasgow, Western Infirmary, 38 Church Street, Glasgow G11 6NT
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Summary

Small vessels showing inflammatory cell infiltrates were invariably observed in the vicinity of intact Toxoplasma tissue cysts within the brains of mice congenitally infected with the protozoan. Lymphocytes were observed in intimate contact with the luminal aspect of the endothelium, penetrating into the thickened basal lamina and in the perivascular area, which also contained macrophages and neutrophilic granulocytes. Rarely, lymphocytes were observed attached to the outer membrane of the host neurone which contained a Toxoplasma tissue cyst and within the inflammatory infiltrate associated with a disintegrating cyst. An hypothesis is presented which combines these morphological observations to explain the events associated with tissue cyst associated recrudescence of latent Toxoplasma infection in mouse brain.

Keywords

Toxoplasmacongenital infectionmouse brainsmall vesselstissue cystsrecrudescence
Type
Research Article
Information
Parasitology , Volume 110 , Issue 2 , February 1995 , pp. 123 - 127
Copyright
Copyright © Cambridge University Press 1995

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References

REFERENCES

Beaman, M. H., Wong, S. Y. & Remington, J. S. (1992). Cytokines, Toxoplasma and intracellular parasitism. Immunological Reviews 127, 97–117.Google Scholar
Beverley, J. K. A. (1959). Congenital transmission of toxoplasmosis through successive generations of mice. Nature, London 183, 1348–9.Google Scholar
Cook, G. C. (1990). Toxoplasma gondii infection: a potential danger to the unborn fetus and AIDS sufferer. Quarterly Journal of Medicine 74, 3–19.Google Scholar
Desmonts, G. (1990). Preventing congenital toxoplasmosis. Lancet 336, 1017–18.Google Scholar
Desmonts, G. & Remington, J. S. (1980). Direct agglutination test for diagnosis of Toxoplasma infection: method for increasing sensitivity and specificity. Journal of Clinical Microbiology 11, 562–8.Google Scholar
Ferguson, D. J. P., Hutchison, W. M. & Petterson, E. (1989). Tissue cyst rupture in mice chronically infected with Toxoplasma gondii. Parasitology Research 75, 599–603.CrossRefGoogle ScholarPubMed
Ferguson, D. J. P., Graham, D. I. & Hutchison, W. M. (1991). Pathological changes in the brains of mice infected with Toxoplasma gondii: a histological immunocytochemical and ultrastructural study. International Journal of Experimental Pathology 72, 463–74.Google Scholar
Frenkel, J. K. (1988). Pathophysiology of toxoplasmosis. Parasitology Today 4, 273–8.Google Scholar
Frenkel, J. K. & Escajadillo, A. (1987). Cyst rupture as a pathogenic mechanism of toxoplasmic encephalitis. American Journal of Tropical Medicine and Hygiene 36, 517–52.Google Scholar
Gazzinelli, R. C., Brezin, A., Li, Q., Nussenblatt, R. B. & Chan, C. -C. (1994). Toxoplasma gondii: acquired ocular toxoplasmosis in the murine model, protective role of TNF-α and IFN-τ. Experimental Parasitology 78, 217–29.CrossRefGoogle Scholar
Graham, D. I., Hay, J., Hutchison, W. M. & Sum, J. C. (1984). Encephalitis in mice with congenital ocular toxoplasmosis. Journal of Pathology 142, 265–77.Google Scholar
Hall, S. M. (1992). Congenital toxoplasmosis. British Medical Journal 305, 291–7.Google Scholar
Hay, J., Aitken, P. P., Hutchison, W. M. & Graham, D. I. (1983). The effect of congenital and adult-acquired Toxoplasma infections on the motor performance of mice. Annals of Tropical Medicine and Parasitology 77, 261–77.Google Scholar
Hay, J., Graham, D. I., Dutton, G. N. & Logan, S. (1986). The immunocytochemical demonstration of Toxoplasma antigen in the brains of congenitally infected mice. Zeitschrift für Parasitenkunde 72, 609–15.Google Scholar
Ho Yen, D. O. & Joss, A. W. L. (1992). Human Toxoplasmosis. Oxford: Oxford University Press.Google Scholar
Huldt, G. (1971). Studies on experimental toxoplasmosis. Annals of the New York Academy of Sciences 177, 146–55.Google Scholar
Hunter, C. A., Roberts, C. W. & Alexander, J. (1992). Kinetics of cytokine mRNA production in the brains of mice with progressive toxoplasmic encephalitis. European Journal of Immunology 22, 2317–22.Google Scholar
Hutchison, W. M. (1986). Strain of mouse and Toxoplasma used in the mouse model of toxoplasmosis at Strathclyde University. Annals of Tropical Medicine and Parasitology 80, 253–4.Google Scholar
Hutchison, W. M., Hay, J., Lee, W. R. & Sum, J. C. (1982). A study of cataract in murine congenital toxoplasmosis. Annals of Tropical Medicine and Parasitology 76, 53–70.Google Scholar
Karnovsky, M. J. (1965). A formaldehyde-glutaraldehyde fixative of high osmolarity for use in electron microscopy. Journal of Cell Biology 27, 137–8.Google Scholar
Kimata, I. & Tanabe, K. (1987). Secretion of Toxoplasma gondii antigen that appears to become associated with the parasitophorous vacuole membrane upon invasion of the host. Journal of Cell Science 88, 231–9.Google Scholar
Koppe, J. G., Loewer-Sieger, D. H. & De Roever-Bonnet, H. (1986). Results of 20-year follow-up of congenital toxoplasmosis. Lancet i, 254–6.Google Scholar
Milon, G. & Louis, J. (1993). CD8+ T-cells and immunity to intracellular pathogens. Parasitology Today 9, 196–7.Google Scholar
Pignatelli, M. & Boomer, W. (1990). Integrin cell adhesion molecules and colorectal cancer. Journal of Pathology 162, 95–7.Google Scholar
Remington, J. S. & Desmonts, G. (1990). Toxoplasmosis. In Infectious Diseases of the Fetus and Newborn Infant, 3rd Edn (ed. Remington, J. S. & Klein, J. O.), pp. 80–195. Philadelphia: W. B. Saunders.Google Scholar
Remington, J. S. & Krahenbuhl, J. L. (1982). Immunology of Toxoplasma gondii. In Immunology of Human Infection, Part II (ed. Nahmias, A. J. & O'Reilly, R. J.), pp. 327–371. Plenum Publishing Co.Google Scholar
Saavedra, R., Meuter, F. & Herion, P. (1990). Monoclonal antibodies identify new Toxoplasma gondii soluble antigens. Hybridoma 9, 453–63.Google Scholar
Shikishima, K., Lee, W. R., Behan, W. M. H. & Foulds, W. S. (1993). Uveitis and retinal vasculitis in acute experimental allergic encephalomyelitis in the Lewis rat: an ultrastructural study. Experimental Eye Research 56, 167–75.Google Scholar
Sims, T. A. (1992). A light and electron microscope investigation of the host-parasite relationship in the brains of mice with congenital toxoplasmosis. Ph.D. thesis, De Montfort University, Leicester.Google Scholar
Sims, T. A. & Hay, J. (1993). Recrudescence of Toxoplasma infection. Parasitology Today 9, 292–3.Google Scholar
Sims, T. A., Hay, J. & Talbot, I. C. (1988). Host-parasite relationship in the brains of mice with congenital toxoplasmosis. Journal of Pathology 156, 255–61.Google Scholar
Sims, T. A., Hay, J. & Talbot, I. C. (1989). An electron microscope and immunohistochemical study of the intracellular location of Toxoplasma tissue cysts within the brains of mice with congenital toxoplasmosis. British Journal of Experimental Pathology 70, 317–25.Google Scholar
Sims, T. A., Hay, J. & Talbot, I. C. (1990). Ultrastructural immunocytochemistry of the intact tissue cyst of Toxoplasma in the brains of mice with congenital toxoplasmosis. Annals of Tropical Medicine and Parasitology 84, 141–7.Google Scholar
Torpier, G., Charif, H., Darcy, F., Liu, J., Darde, M. L. & Capron, A. (1993). Toxoplasma gondii: differential location of antigens secreted from encysted bradyzoites. Experimental Parasitology 77, 13–22.Google Scholar
Wilson, C. B., Remington, J. S., Stagno, S. & Reynolds, D. W. (1980). Development of adverse sequelae in children born with subclinical Toxoplasma infection. Paediatrics 66, 767–74.Google Scholar