Hostname: page-component-76fb5796d-skm99 Total loading time: 0 Render date: 2024-04-26T04:51:10.665Z Has data issue: false hasContentIssue false
  • English
  • Français

Host specificity of and cross-immunity between two strains of Heligmosomoides polygyrus

Published online by Cambridge University Press:  06 April 2009

R.J. Quinnell ,
J. M. Behnke  and
A. E. Keymer
R.J. Quinnell
Affiliation:
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS
J. M. Behnke
Affiliation:
Department of Zoology, University of Nottingham, University Park, Nottingham NG7 2RD
A. E. Keymer
Affiliation:
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS
Get access Rights & Permissions [Opens in a new window]

Extract

The infectivity of wild and laboratory strains of Heligmosomoides polygyrus (Nematospiroides dubius) in laboratory mice and in three species of wild British rodent was compared. Wild strains, of the subspecies H. p. polygyrus, were isolated from wild caught Apodemus sylvaticus. Only very low-level infections of the wild strains became established in laboratory mice. Similar worm burdens of the laboratory strain became established in laboratory mice and A. sylvaticus, although infections in A. sylvaticus were more short lived. Cortisone treatment of hosts increased the establishment and survival of the heterologous worm strain to that of the homologous strain. In contrast, neither strain of parasite established in Clethrionomys glareolus or Microtus agrestis, and cortisone treatment of C. glareolus did not increase establishment. Infection of laboratory mice with the wild-strain parasite induced significant immunity to a challenge infection with the laboratory strain.

Keywords

Heligmosomoides polygyrusNematospiroides dubiusApodemus sylvaticusClethrionomys glareolusMicrotus agrestisinfectioninfectivityhost specificityNematodaimmunity
Type
Research Article
Information
Parasitology , Volume 102 , Issue 3 , June 1991 , pp. 419 - 427
Copyright
Copyright © Cambridge University Press 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Babero, B. B. & Matthias, D. (1967). Protospirura peromysci n. sp. (Nematoda: Spiruridae) and other helminths from Peromyscus spp. in Nevada. Proceedings of the Helminthological Society of Washington 34, 255–61.Google Scholar
Baker, J. P. & Clarke, J. R. (1987). Voles. In The UFAW Handbook on the Care and Management of Laboratory Animals (ed. Poole, T. B.), pp. 331–45. Harlow: Longman.Google Scholar
Baylis, H. A. (1928). On a trichostrongylid nematode from the bank vole (Evotomys glareolus). Annals and Magazine of Natural History, Series 10 1, 280–3.CrossRefGoogle Scholar
Baylis, H. A. (1939). Further records of parasitic worms from British vertebrates. Annals and Magazine of Natural History, Series 11 4, 473–98.CrossRefGoogle Scholar
Behnke, J. M. (1975). Aspiculuris tetraptera in wild Mus musculus. The prevalence of infection in male and female mice. Journal of Helminthology 49, 85–90.CrossRefGoogle ScholarPubMed
Behnke, J. M. (1987). Evasion of immunity by nematode parasites causing chronic infections. Advances in Parasitology 26, 1–17.CrossRefGoogle ScholarPubMed
Behnke, J. M. & Robinson, M. (1985). Genetic control of immunity to Nematospiroides dubius: a 9-day anthelminthic abbreviated immunising regime which separates weak and strong responder strains of mice. Parasite Immunology 7, 235–53.CrossRefGoogle ScholarPubMed
Behnke, J. M. & Wakelin, D. (1973). The survival of Trichuris muris in wild populations of its natural hosts. Parasitology 67, 157–64.CrossRefGoogle ScholarPubMed
Behnke, J. M. & Wakelin, D. (1977). Nematospiroides dubius: the stimulation of acquired immunity in inbred strains of mice. Journal of Helminthology 51, 167–76.CrossRefGoogle ScholarPubMed
Canning, E. U., Cox, F. E. G., Croll, N. A. & Lyons, K. A. (1973). The natural history of Slapton Ley nature reserve. VI. Studies on the parasites. Field Studies 3, 681–718.Google Scholar
Cross, J. H. (1960). The natural resistance of the white rat to Nematospiroides dubius and the effect of cortisone on this resistance. Journal of Parasitology 46, 175–85.CrossRefGoogle ScholarPubMed
Cross, J. H. & Duffy, C. E. (1963). Nematospiroides dubius in the abnormal host. Annals of the New York Academy of Sciences 113, 88–99.CrossRefGoogle ScholarPubMed
Dirkmans, G. A. (1940). A note on the genera Nematospiroides Baylis, 1926 and Sincosta Roe, 1929 (Nematoda, Heligmosomidae), with descriptions of two new species of Nematospiroides. Proceedings of the Helminthological Society of Washington 7, 79–82.Google Scholar
Dunn, A. & Keymer, A. E. (1985). Factors affecting the reliability of the McMaster technique. Journal of Helminthology 60, 260–2.CrossRefGoogle Scholar
Durette-Desset, M-C. (1968 a). Identification des strongles des mulots et campagnols decrits par Dujardin. Annales de Parasitologie (Paris) 43, 387–404.Google Scholar
Durette-Desset, M-C. (1968 b). Les systemes des cretes cuticulaires chez les nematodes heligmosomes. III. Etude de sept especes parasites de rongeurs nearctiques et retablissement du genre Heligmosomoides Hall, 1916. Bulletin Museum Nationale d'Histoire Naturelle 40, 186–209.Google Scholar
Durette-Desset, M-C. (1985). Trichostrongylid nematodes and their vertebrate hosts: reconstruction of the phylogeny of a parasitic group. Advances in Parasitology 24, 239–306.CrossRefGoogle Scholar
Durette-Desset, M-C., Kinsella, J. M. & Forrester, D. J. (1972). Arguments en faveur de la double origine des nematodes nearctiques du genre Heligmosomoides Hall, 1916. Annales de Parasitologies (Paris) 47, 365–82.Google Scholar
Ehrenford, F. A. (1954). The life-cycle of Nematospiroides dubius Baylis (Nematoda: Heligmosomidae). Journal of Parasitology 40, 480–1.CrossRefGoogle Scholar
Elton, C., Ford, E. B., Baker, J. R. & Gardner, A. D. (1931). The health and parasites of a wild mouse population. Proceedings of the Zoological Society of London, 2, 657–721.CrossRefGoogle Scholar
Fahmy, M. A. M. (1956). An investigation on the life-cycle of Nematospiroides dubius (Nematoda: Heligmosomidae) with special reference to the free-living stages. Zeitschrift für Parasitenkunde 17, 394–9.CrossRefGoogle Scholar
Forrester, D. J. (1971). Heligmosomoides polygyrus (= Nematospiroides dubius) from wild rodents of northern California: natural infections, host specificity and strain characteristics. Journal of Parasitology 57, 498–503.CrossRefGoogle ScholarPubMed
Forrester, D. J. & Neilson, J. T. MCL. (1973). Comparative infectivity of Heligmosomoides polygyrus (= Nematospiroides polygyrus) in the three species of Peromyscus. Journal of Parasitology 59, 251–5.CrossRefGoogle ScholarPubMed
Furmaga, S. (1957). Helmintofauna gryzoni polnych (Rodentia) okolic Lublina. Acta Parasitologica Polonica 5, 9–50.Google Scholar
Gregory, R. D., Keymer, A. E. & Clarke, J. R. (1990). Genetics, sex and exposure: the ecology of Heligmosomoides polygyrus (Nematoda) in the wood mouse. Journal of Animal Ecology 59, 363–78.CrossRefGoogle Scholar
Hannah, J. (1983). Studies on the host-parasite relationships of Nematospiroides dubius in normal and abnormal hosts. Ph.D. thesis, University of Nottingham.Google Scholar
Hannah, J. & Behnke, J. M. (1982). Nematospiroides dubius in the jird, Meriones unguiculatus: factors affecting the course of a primary infection. Journal of Helminthology 56, 329–38.CrossRefGoogle ScholarPubMed
Helper, D. I. & Leuker, D. C. (1976). Native resistance of Peromyscus maniculatus to Nematospiroides dubius infection. Experimentia 32, 386–7.Google Scholar
James, P. M. (1954). On some helminths from British small mammals, with a redescription of Echinorhynchus rosai Porta 1910. Journal of Helminthology 28, 183–8.CrossRefGoogle ScholarPubMed
Jenkins, D. C. (1977). Nematospiroides dubius: the course of primary and challenge infections in the jird, Meriones unguiculatus. Experimental Parasitology 41, 335–40.CrossRefGoogle ScholarPubMed
Jenkins, S. N. & Behnke, J. M. (1977). Impairment of primary expulsion of Trichuris muris in mice concurrently infected with Nematospiroides dubius. Parasitology 75, 71–8.CrossRefGoogle ScholarPubMed
Keymer, A. E. & Hiorns, R. W. (1986). Heligmosomoides polygyrus (Nematoda): the dynamics of primary and repeated infection in outbred mice. Proceedings of the Royal Society of London, B 229, 47–67.Google ScholarPubMed
Kinsella, J. M. (1967). Helminths of Microtinae in western Montana. Canadian Journal of Zoology 45, 269–74.CrossRefGoogle Scholar
Kisielewska, K. (1970). Ecological organisation of intestinal helminth groupings in Clethrionomys glareolus (Schreb.) (Rodentia). I. Structure and seasonal dynamics of helminth groupings in a host population in Bialowieza National Park. Acta Parasitologica Polonica 18, 121–47.Google Scholar
Kuns, M. L. & Rausch, R. (1950). An ecological study of helminths of some Wyoming voles (Microtus spp.) with a description of a new species of Nematospiroides (Heligmosomidae: Nematoda). Zoologica, New York 35, 181–8.Google Scholar
Lewis, J. W. (1968 a). Studies on the helminth parasites of the long-tailed field mouse, Apodemus sylvaticus from Wales. Journal of Zoology 154, 287–312.CrossRefGoogle Scholar
Lewis, J. W. (1968 b). Studies on the helminth parasites of voles and shrews from Wales. Journal of Zoology 154, 313–31.CrossRefGoogle Scholar
Lewis, J. W. (1987). Helminth parasites of British rodents and insectivores. Mammal Review 17, 81–94.CrossRefGoogle Scholar
Lewis, J. W. & Twigg, G. I. (1972). A study of the internal parasites of small rodents from woodland areas in Surrey. Journal of Zoology 166, 61–77.CrossRefGoogle Scholar
Newton, W. L., Weinstein, P. P. & Jones, M. F. (1959). A comparison of the development of some rat and mouse helminths in germfree and conventional guinea pigs. Annals of New York Academy of Sciences 78, 290–306.CrossRefGoogle ScholarPubMed
Rainbow, J. M. T. (1971). Studies on the helminth parasites of small mammals, with particular reference to the ecology and physiology of the nematode Nematospiroides dubius Baylis 1926. Ph.D. thesis, University of London.Google Scholar
Sharpe, G. I. (1964). The helminth parasites of some small mammal communities. I. The parasites and their hosts. Parasitology 54, 145–54.CrossRefGoogle ScholarPubMed
Slater, A. F. G. & Keymer, A. E. (1986). Heligmosomoides polygyrus (Nematoda): the influence of dietary protein on the dynamics of repeated infection. Proceedings of the Royal Society of London, B 229, 69–83.Google ScholarPubMed
Tenora, F. (1966). Some remarks on the species of the genus Heligmosomum Railliet et Henry, 1909 with an asymmetric bursa copulatrix. Folia Parasitologica 13, 205–11.Google Scholar
Tenora, F. & Meszaros, F. (1971). Nematodes of the genus Heligmosomum Railliet et Henry, 1909, sensu Durette-Desset, 1968, parasitizing rodents in Europe. Acta Zoologica Academiae Scientiarum Hungaricae 17, 397–407.Google Scholar
Tenora, F., Quentin, J. C. & Durette-Desset, M-C. (1974). Some new findings of nematodes of the families Oxyuridae and Heligmosomidae (Nematoda) in Czechoslovakia and Poland. Vestnik Ceskoslovenske Spolecnosti Zoologicke 38, 71–5.Google Scholar
Thomas, R. J. (1953). On the nematode and trematode parasites of some small mammals from the Inner Hebrides. Journal of Helminthology 27, 143–68.CrossRefGoogle Scholar
Wahid, F. N., Behnke, J. M. & Conway, D. J. (1989). Factors affecting the efficacy of Ivermectin against Heligmosomoides polygyrus (Nematospiroides dubius) in mice. Veterinary Parasitology 32, 325–40.CrossRefGoogle ScholarPubMed
Whitaker, J. O. (1970). Parasites of feral house mice, Mus musculus, in Vigo Country, Indiana. Proceedings of the Indiana Academy of Sciences 79, 441–8.Google Scholar