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Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta

Published online by Cambridge University Press:  17 March 2010

L. MURPHY ,
P. D. ECKERSALL ,
S. C. BISHOP ,
J. J. PETTIT ,
J. F. HUNTLEY ,
R. BURCHMORE  and
M. J. STEAR
L. MURPHY
Affiliation:
Glasgow University Veterinary School, Bearsden Road, GlasgowG61 1QH
P. D. ECKERSALL
Affiliation:
Glasgow University Veterinary School, Bearsden Road, GlasgowG61 1QH
S. C. BISHOP
Affiliation:
Roslin Institute and R(D)VS, University of Edinburgh, Roslin, MidlothianEH25 9PS
J. J. PETTIT
Affiliation:
Moredun Research Institute, Pentland Science Park, PenicuikEH26 0PZ
J. F. HUNTLEY
Affiliation:
Moredun Research Institute, Pentland Science Park, PenicuikEH26 0PZ
R. BURCHMORE
Affiliation:
Faculty of Biomedical and Life Sciences, Glasgow University, University Avenue, GlasgowG12 8QQ
M. J. STEAR*
Affiliation:
Glasgow University Veterinary School, Bearsden Road, GlasgowG61 1QH
*
*Corresponding author: Glasgow University Veterinary School, Bearsden Road, GlasgowG61 1QH. E-mail: m.j.stear@vet.gla.ac.uk
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Summary

IgA and IgE activity against Teladorsagia circumcincta was investigated in a flock of Texel lambs following natural, mixed nematode infection among lambs. The distribution of IgA activity was similar to a gamma distribution whereas IgE activity was different. Box-Cox analysis demonstrated that X0·25 was a suitable transformation to normalise IgE responses. The transformed IgE activity was under moderate to strong genetic control. Nine different allergens were identified by proteomic analysis. Tropomyosin was selected for further analysis. IgE activity against tropomyosin was moderately heritable and associated with decreased egg counts and with reduced body weight at the time of sampling.

Keywords

Ovis ariesTeladorsagia circumcinctasheepIgEtropomyosinfaecal egg countsliveweight
Type
Research Article
Information
Parasitology , Volume 137 , Issue 8 , July 2010 , pp. 1249 - 1260
Copyright
Copyright © Cambridge University Press 2010

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