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Genes within the major histocompatibility complex of the guinea pig influence susceptibility to Trichostrongylus colubriformis infection

Published online by Cambridge University Press:  06 April 2009

A. F. Geczy  and
T. L. W. Rothwell
A. F. Geczy
Affiliation:
N. S. W. Red Cross Blood Transfusion Service, 153 Clarence Street, Sydney 2000, N. S. W., Australia
T. L. W. Rothwell
Affiliation:
Department of Veterinary Pathology, University of Sydney, N. S. W. 2006, Australia
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Summary

The influence of genes in the major histocompatibility complex (MHC) of the guinea pig on the susceptibility to infection with the parasitic nematode Trichostrongylus colubriformis was investigated. Back-cross analysis of 2 lines of guinea pigs suggests that genes that map in or near the I region of the guinea pig MHC influence susceptibility to infection by the parasite. However, other genes, possibily not linked to the guinea pig MHC, may also be required for the full expression of susceptibility.

Type
Research Article
Information
Parasitology , Volume 82 , Issue 2 , April 1981 , pp. 281 - 286
Copyright
Copyright © Cambridge University Press 1981

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