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Evidence that primary infection of Charollais sheep with Toxoplasma gondii may not prevent foetal infection and abortion in subsequent lambings

  • E. K. MORLEY (a1), R. H. WILLIAMS (a1), J. M. HUGHES (a1), D. THOMASSON (a1), R. S. TERRY (a2), P. DUNCANSON (a1), J. E. SMITH (a2) and G. HIDE (a1)...

Summary

A study carried out on a sheep farm examined whether Toxoplasma gondii foetal infection and associated abortion occur in successive lambings. We identified 29 ewes that gave birth to lambs on at least 2 successive years over our study period, 2000–2003. Tissue samples from the progeny of these ewes were analysed by PCR to determine infection status with T. gondii. T. gondii-infected lambs were born in 31% of successive pregnancies. T. gondii-positive lambs were aborted in successive pregnancies in 21% of lambings during study period, 2000–2003. The frequency of successive abortions within this flock over the period 1992–2003 was 18%. If a lamb was congenitally infected there was a high risk (69%) that the successive lamb from that ewe would also be congenitally infected. Similarly, if a lamb was aborted there was a high risk (55%) of abortion in the next lamb produced. These data suggest that life-long immunity to T. gondii infections may not always be acquired following an initial infection and raises the question as to whether the mechanisms of T. gondii transmission prior to and during ovine pregnancies are fully understood.

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Corresponding author

*Corresponding author: Centre for Parasitology and Disease, Biomedical Sciences Research Institute, School of Environment and Life Sciences, University of Salford, Salford M5 4WT, UK. Tel: +0161 295 3371. Fax: +0161 295 5015. E-mail: g.hide@salford.ac.uk

References

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Avelino, M. M. and Campos, D. Jr. (2002). Pregnancy as a risk factor for acute toxoplasmosis seroconversion. European Journal of Obstetrics and Gynecology and Reproductive Biology 4417, 16.
Beverley, J. K. A., Watson, W. A. and Payne, J. M. (1971). The pathology of the placenta in ovine abortion due to toxoplasmosis. Veterinary Record 88, 124128.
Boothroyd, J. C. and Grigg, M. E. (2002). Population biology of Toxoplasma gondii and its relevance to human infection: do different strains cause different disease? Current Opinion in Microbiology 5, 438442.
Boyer, K. M., Remington, J. S. and MacLeod, R. L. (1998). Textbook of Pediatric Infectious Diseases, W.B. Saunders Company, Philadelphia, USA.
Buxton, D., Rodger, S. M., Maley, S. W. and Wright, S. E. (2006). Toxoplasmosis: The possibility of vertical transmission. Small Ruminant Research 62, 4346.
Buxton, D., Maley, S. W., Wright, S. E., Rodger, S., Bartley, P. and Innes, E. A. (2007). Toxoplasma gondii and ovine toxoplasmosis: New aspects of an old story. Veterinary Parasitology 149, 2528.
Buxton, D. and Innes, E. A. (1995). A commercial vaccine for ovine toxoplasmosis. Parasitology 110, 1116.
Desmonts, G., Naot, Y. and Remington, J. S. (1981). Immunolglobulin M-immunosorbent agglutination assay for diagnosis of infectious diseases: diagnosis of acute congenital and acquired Toxoplasma infections. Journal of Clinical Microbiology 14, 486491.
Dubey, J. P. and Beattie, C. P. (1988). Toxoplasmosis of Animals and Man. CRC Press, Boca Raton, Florida, USA.
Duncanson, P., Terry, R. S., Smith, J. E. and Hide, G. (2001). High levels of congenital transmission of Toxoplasma gondii in a commercial sheep flock. International Journal for Parasitology 31, 16991703.
Frenkel, J. K. (1990). Toxoplasmosis in human beings. Journal of the American Veterinary Medical Association 196, 240248.
Hughes, J. M., Williams, R. H., Morley, E. K., Cook, D. A.N., Terry, R. S., Murphy, R. G., Smith, J. E. and Hide, G. (2006). The prevalence of Neospora caninum and co-infection with Toxoplasma gondii by PCR analysis in naturally occurring mammal populations. Parasitology 132, 2936.
Marshall, P. A., Hughes, J. M., Williams, R. H., Smith, J. E., Murphy, R. G. and Hide, G. (2004). Detection of high levels of congenital transmission of Toxoplasma gondii in natural urban populations of Mus domesticus. Parasitology 128, 3942.
McColgan, C., Buxton, D. and Blewett, D. A. (1988). Titration of Toxoplasma gondii oocysts in non-pregnant sheep and the effects of subsequent challenge during pregnancy. Veterinary Record 123, 467470.
Morley, E. K., Williams, R. H., Hughes, J. M., Terry, R. S., Duncanson, P., Smith, R. S. and Hide, G. (2005). Significant familial differences in the frequency of abortion and Toxoplasma gondii infection within a flock of Charollais sheep. Parasitology 131, 181185.
Quinn, H. E., Ellis, J. T. and Smith, N. C. (2002). Neospora caninum: a cause of immune-mediated failure of pregnancy? Trends in Parasitology 18, 391394.
Remington, J. S. and Desmonts, G. (1990). Toxoplasmosis. In Infectious Disease of the Fetus and Newborn Infant (ed. Remington, J. S. and Klein, J. O.),pp. 143146. W.B. Saunders, Philadelphia, USA.
Tenter, A. M., Heckeroth, A. R. and Weiss, L. M. (2000). Toxoplasma gondii: from animals to humans. International Journal for Parasitology 30, 12171258.
Terry, R. S., Smith, J. E., Duncanson, P. and Hide, G. (2001). MGE-PCR: a novel approach to the analysis of Toxoplasma gondii strain differentiation using mobile genetic elements. International Journal for Parasitology 31, 155161.
Trees, A. J. and Williams, D. J. L. (2005). Endogenous and exogenous transplacental infection in Neospora caninum and Toxoplasma gondii. Trends in Parasitology 21 558561.
Veterinary Laboratories Agency (VLA) (2006). Monthly Surveillance Report, February 2006.
VIDA (2003). Veterinary Surveillance Report 2003 – VIDA. Veterinary Laboratories Agency. ISBN 1 8995 1322 1
Williams, R. H., Morley, E. K., Hughes, J. M., Duncanson, P., Terry, R. S., Smith, J. E. and Hide, G. (2005). High levels of congenital transmission of Toxoplasma gondii in longitudinal and cross-sectional studies on sheep farms provides evidence of vertical transmission in ovine hosts. Parasitology 130, 301307.
Zuber, P. and Jaquier, P. (1995). Epidemiology of toxoplasmosis: worldwide status. Schweizerische Medizinische Wochenschrift 65, 19S22S.

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