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The effects of H-2 and non-H-2 genes on the expulsion of the nematode Trichuris muris from inbred and congenic mice

Published online by Cambridge University Press:  06 April 2009

Kathryn Else  and
D. Wakelin
Kathryn Else
Affiliation:
MRC Experimental Parasitology Unit, Department of Zoology, University of Nottingham, Nottingham NG1 2RD
D. Wakelin
Affiliation:
MRC Experimental Parasitology Unit, Department of Zoology, University of Nottingham, Nottingham NG1 2RD
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Summary

Two groups of H-2 congenic strains of mice were compared for their susceptibility to a primary infection with the nematode Trichuris muris. Mice of the BALB genetic background were markedly more resistant than mice of the BIO genetic background, as reflected by the rate of expulsion of T. muris from the large intestine. Within each of the two groups of H-2 congenic strains mice possessing the H-2k haplotype (BALB/k, B10.BR) were more susceptible to infection than mice expressing other haplotypes; B10 background strains expressing H-2b (B10) or H-2q (B10.G) alleles were the most resistant of the four congenic strains studied. Differential resistance was observed within three of the four BIO congenic strains and this is discussed in terms of rate of development of the protective immune response in relation to worm development. The results support the conclusion that both H-2-linked and non-H-2 genes play important roles in controlling the immune response which expels worms from the gut.

Type
Research Article
Information
Parasitology , Volume 96 , Issue 3 , June 1988 , pp. 543 - 550
Copyright
Copyright © Cambridge University Press 1988

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References

REFERENCE

Bell, R. G., & McGregor, D. D., (1980). Variation in anti-Trichinella responsiveness in inbred mouse strains. In Genetic Control of Natural Resistance to Infection and Malignancy (ed. Skamene, E., Kongshavn, P. A. L. and Landy, M.), p. 67. New York: Academic Press.CrossRefGoogle Scholar
Bell, R. G., McGregor, D. D., & Adams, L. S., (1982 a). Trichinella spiralis: Characterization and strain distribution of rapid expulsion in inbred mice. Experimental Parasitology 53, 301–14.CrossRefGoogle ScholarPubMed
Bell, R. G., McGregor, D. D., & Adams, L. S., (1982 b). Trichinella spiralis. Genetic basis for differential expression of phase-specific intestinal immunity in inbred mice. Experimental Parasitology 53, 315–25.CrossRefGoogle ScholarPubMed
Bundy, D. A. P., (1986). Epidemiological aspects of Trichuris and trichuriasis in Caribbean communities. Transactions of the Royal Society of Tropical Medicine and Hygiene 80, 706–18.CrossRefGoogle ScholarPubMed
Campbell, W. C., & Collette, J. V., (1962). Effect of cortisone upon infection with Trichuris muris in albino mice. Journal of Parasitology 48, 933–4.CrossRefGoogle Scholar
Lee, T. D. G., & Wakelin, D., (1982). The use of host strain variation to assess the significance of mucosal mast cells in the spontaneous cure response of mice to the nematode Trichuris muris. International Archives of Allergy and Applied Immunology 67, 302–5.CrossRefGoogle Scholar
Roach, T. I. A., (1986). Immunity to Trichuris muris in the mouse. Ph.D. thesis, Nottingham University.Google Scholar
Wakelin, D., (1967). Acquired immunity to Trichuris muris in the albino laboratory mice. Parasitology 57, 515–24.CrossRefGoogle Scholar
Wakelin, D., (1973). The stimulation of immunity to Trichuris muris in mice exposed to low-level infections. Parasitology 66, 181–9.CrossRefGoogle ScholarPubMed
Wakelin, D., (1975 a). Immune expulsion of Trichuris muris from mice during a primary infection: analysis of the components involved. Parasitology 70, 397–405.CrossRefGoogle ScholarPubMed
Wakelin, D., (1975 b). Genetic control of immune responses to parasites: immunity to Trichuris muri in inbred and random-bred strains of mice. Parasitology 71, 51–60.CrossRefGoogle Scholar
Wakelin, D., (1980). Genetic control of immunity to parasites. Infection with Trichinella spiralis in inbred and congenic mice showing rapid and slow responses to infection. Parasite Immunology 2, 85–98.CrossRefGoogle Scholar
Wakelin, D., (1985). Genetic control of immunity to helminth infections. Parasitology Today 1, 17–23.CrossRefGoogle ScholarPubMed
Wakelin, D., & Donachie, A. M., (1980). Genetic control of immunity to parasites: adoptive transfer of immunity between inbred strains of mice characterized by rapid and slow immune expulsion of Trichinella spiralis. Parasite Immunology 2, 249–60.CrossRefGoogle ScholarPubMed
Wakelin, D., & Donachie, A. M., (1981). Genetic control of immunity to Trichinella spiralis. Donor bone marrow cells determine responses to infection in mouse radiation chimaeras. Immunology 43, 787–92.Google ScholarPubMed
Wakelin, D., & Donachie, A. M., (1983). Genetic control of immunity to Trichinella spiralis: influence of H-2 linked genes on immunity to the intestinal phase of infection. Immunology 48, 343–50.Google Scholar
Wassom, D. L., Brooks, B. O., & Cypess, R. H., (1983). Trichinella spiralis: Role of non-H-2 genes in resistance to primary infection in mice. Experimental Parasitology 55, 153–8.CrossRefGoogle ScholarPubMed
Wassom, D. L., David, C. S., & Gleich, G. J., (1979). Genes within the major histocompatibility complex influence susceptibility to Trichinella spiralis in the mouse. Immunogenetics 9, 491–6.CrossRefGoogle Scholar
Wassom, D. L., Krco, C. J., & David, C. S., (1987). I-E expression and susceptibility to parasite infection. Immunology Today 8, 39–43.CrossRefGoogle Scholar
Wassom, D. L., Wakelin, D., Brooks, B. O., Krco, C. J., & David, C. S., (1984). Genetic control of immunity to Trichinella spiralis infections of mice. Hypothesis to explain the role of H-2 genes in primary and challenge infections. Immunology 51, 625–31.Google ScholarPubMed
Worley, D. E., Meisenhelder, J. E., Sheffield, H. G., & Thompson, P. E., (1962). Experimental studies on Trichuris muris in mice with an appraisal of its use for evaluating anthelmintics. Journal of Parasitology 48, 433–47.CrossRefGoogle ScholarPubMed