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The effect of immune inhibition on pleomorphism in Trypanosoma brucei rhodesiense

Published online by Cambridge University Press:  06 April 2009

W. E. Ormerod ,
S. Venkatesan ,
R. G. Carpenter  and
Angela Gardner
W. E. Ormerod
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT
S. Venkatesan
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT
R. G. Carpenter
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT
Angela Gardner
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT
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Extract

The effect of immune inhibition on the pleomorphism of Trypanosoma brucei was studied by counting trypomastigotes and their granules on agar. A statistical analysis is presented. Busulphan 32 mg/kg, given 24 h before inoculation, caused an inhibition of the infection detectable at 72 h, but not thereafter. Immune inhibition caused by busulphan was associated with increased numbers both of agranular forms and forms containing lipid (type II) granules. After 96 h, treatment did not alter the proportion of agranular to granular forms. The remission was delayed 24 h in treated rats, the remaining trypomastigotes being more sluggish, more fragile and containing more numerous granules of increased size. We conclude that the remission is not produced by the immune reaction but by an innate process of dissolution of the ageing trypomastigotes.

Type
Research Article
Information
Parasitology , Volume 68 , Issue 3 , June 1974 , pp. 355 - 367
Copyright
Copyright © Cambridge University Press 1974

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References

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