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Clustering of Brugia malayi infection in a community in South-Sulawesi, Indonesia

  • A. J. TERHELL (a1), J. J. HOUWING-DUISTERMAAT (a2), Y. RUITERMAN (a1), M. HAARBRINK (a1), K. ABADI (a3) and M. YAZDANBAKHSH (a1)...

Abstract

The present study was undertaken in village Karondang in South-Sulawesi, Indonesia, to investigate the influences of genetic, household and environmental factors on Brugia malayi infection. Infection status was determined by measuring both microfilariae in night blood and anti-filarial IgG4, as a marker for detection of active filarial infection. A total of 171 residents participated in the study; familial relationships between subjects were registered to construct pedigrees and distances between households were measured. The data were analysed using a test statistic for familial aggregation. For distribution of microfilariae over the study population a genetic influence on infection susceptibility was favoured over the household and environmental effects. For anti-filarial IgG4, all 3 clustering models gave significant results, suggesting that genetic, household and/or environmental factors influence specific IgG4 antibodies.

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Corresponding author: Department of Parasitology, Leiden University Medical Centre, PO Box 9605, 2300 RC, Leiden, The Netherlands. Tel: +31 71 5276863. Fax: +31 71 5276850. E-mail: A.J.Terhell@Parasitology.medfac.leidenuniv.nl

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