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Cloning of peroxiredoxin, a novel antioxidant enzyme, from the helminth parasite Fasciola hepatica

  • S. McGONIGLE (a1), G. P. CURLEY (a1) and J. P. DALTON (a1)

Abstract

A cDNA was isolated from a cDNA expression library using serum prepared against a high molecular mass fraction of Fasciola hepatica excretory–secretory products. The full-length cDNA encodes a member of the recently described peroxiredoxin antioxidant family. Peroxiredoxin could be the major hydrogen peroxide removing antioxidant in F. hepatica since this parasite does not express a catalase and expresses little glutathione peroxidase activity. This novel antioxidant may be involved in functions such as protection against reactive oxygen species (ROS) generated by metabolic processes and/or protection of the parasite against ROS released by immune effector cells.

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Corresponding author

School of Biological Sciences, Dublin City University, Dublin 9, Ireland. Tel: +353 1 7045407. Fax: +353 1 7045412. E-mail: daltonj@ccmail.dcu.ie.

Keywords

Cloning of peroxiredoxin, a novel antioxidant enzyme, from the helminth parasite Fasciola hepatica

  • S. McGONIGLE (a1), G. P. CURLEY (a1) and J. P. DALTON (a1)

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