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Cloning of peroxiredoxin, a novel antioxidant enzyme, from the helminth parasite Fasciola hepatica

Published online by Cambridge University Press:  01 July 1997

S. McGONIGLE ,
G. P. CURLEY  and
J. P. DALTON
S. McGONIGLE
Affiliation:
School of Biological Sciences, Dublin City University, Dublin 9, Ireland
G. P. CURLEY
Affiliation:
School of Biological Sciences, Dublin City University, Dublin 9, Ireland
J. P. DALTON
Affiliation:
School of Biological Sciences, Dublin City University, Dublin 9, Ireland
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Abstract

A cDNA was isolated from a cDNA expression library using serum prepared against a high molecular mass fraction of Fasciola hepatica excretory–secretory products. The full-length cDNA encodes a member of the recently described peroxiredoxin antioxidant family. Peroxiredoxin could be the major hydrogen peroxide removing antioxidant in F. hepatica since this parasite does not express a catalase and expresses little glutathione peroxidase activity. This novel antioxidant may be involved in functions such as protection against reactive oxygen species (ROS) generated by metabolic processes and/or protection of the parasite against ROS released by immune effector cells.

Keywords

Fasciola hepaticatrematodeperoxiredoxinthiol-specific antioxidantantioxidants
Type
Research Article
Information
Parasitology , Volume 115 , Issue 1 , July 1997 , pp. 101 - 104
Copyright
1997 Cambridge University Press

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